Castleman's disease of the cervical region: a case report

Yıl 2005, Cilt: 14 Sayı: 1, 25 - 38, 20.02.2005

Çağlar Çallı Semih Öncel Ercan Pınar Elif Güçlü Aylin Çallı Melda Apaydın

Öz

Castleman’s disease is a rare disorder characterized by massive proliferation of the lymphoid tissue due to an unknown cause. Two clinical types localized, mul- ticentric have been described with three histological variants hyaline-vascular, plasma celi, and mixed type . A 47-year-old female patient was referred to our department because of a swelling in the posterior cer­ vical region. Fine-needle aspiration biopsy was suggestive of lymphoma. Total excision of the mass was performed under general anesthesia with intraopera- tive frozen section examination. Histopathologic diag- nosis was Castleman’s disease of hyaline-vascular type. Castleman’s disease should also be considered for suspicious masses in the neck.

Anahtar Kelimeler

Giant lymph node hyperplasia/pathology/ surgery, head and neck neoplasms/diagnosis

Servikal bölgede Castleman hastalığı: Olgu sunumu

Öz

Castleman hastalığı, lenfoid dokunun masif prolife- rasyonu ile ilişkili olan, nedeni bilinmeyen, nadir gö- rülen bir durumdur. Hastalığın üç histolojik varyantı hyalin-vasküler, plazma hücreli ve mikst tip ile loka- lize ve multisentrik olmak üzere iki klinik tipi tanım- lanmıştır. Kliniğimize boynun sol tarafında posterior servikal bölgede şişlik şikayetiyle başvuran 47 ya- şındaki bir kadın hastanın yapılan ince iğne biyopsi- sinde lenfoma şüphesi bulunması üzerine, kitle ge- nel anestezi altında frozen çalışması yapılarak çıka- rıldı. Ameliyat sonrası histopatolojik tanı, hyalin-vas- küler tip Castleman hastalığı olarak bildirildi. Castle- man hastalığı, boyundaki şüpheli kitlelerde akla ge- tirilmesi gereken bir durumdur

Anahtar Kelimeler

Dev lenf nodu hiperplazisi/patoloji/cerrahi, baş-boyun neoplazileri/tanı

Kaynakça

• CASE records of the Massachusetts General Hospital Weekly Clinicopathological Exercises: Case 40011. N Engl J Med 1954;250:26-30.
• Slotwiner A, Garwacki CP, Moll S. Castleman's dis- ease. Am J Hematol 2003;73:64-5.
• Ioachim HL. Lymph node pathology. 2nd ed. Philadelphia: J.B. Lippincott Company; 1994. p. 236-43.
• Keller AR, Hochholzer L, Castleman B. Hyaline-vascu- lar and plasma-cell types of giant lymph node hyper- plasia of the mediastinum and other locations. Cancer 1972;29:670-83.
• van den Berge M, Pauwels P, Jakimowicz JJ, Creemers GJ. Hyaline vascular Castleman’s disease: a case report and brief review of the literature. Neth J Med 2002;60:444-7.
• Bond SE, Saeed NR, Palka I, Carls FP. Castleman’s dis- ease presenting as a midline neck mass. Br J Plast Surg 2003;56:62-4.
• Bjarnason I, Cotes PM, Knowles S, Reid C, Wilkins R, Peters TJ. Giant lymph node hyperplasia (Castleman’s disease) of the mesentery. Observations on the associ- ated anemia. Gastroenterology 1984;87:216-23.
• Nordstrom DG, Tewfik HH, Latourette HB. Plasma cell giant lymph node hyperplasia responding to radi- ation therapy. AJR Am J Roentgenol 1978;130:169-71.
• Osma U, Cureoglu S, Yaldiz M, Topcu I. Castleman’s disease (giant lymph node hyperplasia) of the neck: a case report. Eur Arch Otorhinolaryngol 2001;258:42-4.
• Üçüncü H, Aktan B, Karaşen RM, Altaş E, Gürsan N, Şirin S. Castleman hastalığı. Türk Otolarengoloji Arşivi 1997;35:115-7.