The effect of exercise on salivary IgA levels and the incidence of upper respiratory tract infections in postmenopausal women

Yıl 2005, Cilt: 15 Sayı: 5, 112 - 116, 03.10.2005

Figen Çiloğlu

Öz

Objectives: To examine the patterns of upper respiratory tract infections URTI in postmenopausal Turkish women and the relationship of moderate aerobic exercise with secretion of salivary IgA and episodes of URTI.Materials and Methods: Ninety healthy, sedentary women at ages 45 to 65 years volunteered to participate in a 12-week prospective study. They were randomized to three groups equal in number: indoor exercise, outdoor exercise, and no exercise. The exercising women were supervised during 30 min indoor treadmill walk or outdoor track vvalking sessions during 5 days/week at 60% of their calculated maximal heart rate. During a 12-week exercise program, episodes suggestive of URTI were recorded.Non-exercising women were follovved with vveekly tele- phone calls. The salivary IgA levels were measured in ali the subjects before and at the end of the study.Results: There were significant differences betvveen the exercising and non-exercising women with respect to the number of URTI episodes and the length of URTI symp- tomatology per episode in favor of exercise. No signifi­ cant difference was found betvveen the indoor and out­ door exercising groups. The salivary IgA levels shovved no significant differences betvveen the three groups and vvithin each group.Conclusion: Moderate intensity aerobic exercise is associated vvith fevver episodes of URTI and fevver days of URTI symptomatology per episode in healthy post­ menopausal Turkish vvomen, but this does not seem to be related to salivary IgA concentrations.

Anahtar Kelimeler

Exercise/physiology, female, immunoglobulin asecretory, oxygen consumption, postmenopause, respirato­ry tract infections, saliva/immunology

Menopoz sonrası dönemde kadınlarda üst solunum yolu enfeksiyonları sıklığı ve egzersizin tükürük IgA sekresyonuna etkisi

Öz

Amaç: Menopoz sonrası dönemdeki Türk kadınlarındaüst solunum yolu enfeksiyonu ÜSYE tiplerini araştırmak ve orta düzeydeki aerobik egzersiz ile tükürük IgAsekresyonu ve ÜSYE arasındaki ilişkiyi incelemek.Olgular ve Yöntemler: On iki haftalık bu prospektif çalışmaya, gönüllü olarak katılmayı kabul eden, 45-65 yaşlarında, sağlıklı, sedanter yaşayan 90 kadın alındı. Kadınlar, ev içi veya dışında egzersiz yapan veya egzersiz yapmayan olmak üzere sayıca eşit üç gruba ayrıldı. Egzersizyapan kadınlara, haftada beş gün, günde 30 dakika süreli ev içi yürüme bandında veya dışarda, maksimal kalp hızının %60’ını geçmeyecek şekilde yürüme egzersizleriverildi. On iki haftalık sürede ÜSYE düşündüren semptomlar kaydedildi. Egzersiz yapmayan kadınlar haftalıktelefon konuşmalarıyla izlendi. Tüm katılanların çalışmaöncesi ve bitiminde tükürük IgA düzeyleri ölçüldü.Bulgular: Egzersiz yapan ve yapmayan kadınlar arasında, ÜSYE epizodlarının sayısı ve epizod başınaÜSYE semptomatolojisinin süresi açısından, egzersizgrupları lehine anlamlı farklılık görüldü. Ev içinde vedışında egzersiz yapanlar arasında bu açıdan farklılıkyoktu. Tükürük IgA düzeyleri gruplar arasında ve herbir grupta çalışma öncesi ve sonrasında farklılık göstermedi.Sonuç: Orta ağırlıkta aerobik egzersiz yapan sağlıklıpostmenopozal Türk kadınlarında daha az sayıda ÜSYE epizodu ve epizod başına daha kısa süren ÜSYEsemptomatolojisi görüldüğü ve egzersizin tükürük IgAkonsantrasyonuyla ilişkisi olmadığı sonucuna varıldı

Anahtar Kelimeler

Egzersiz/fizyoloji, kadın, immünglobulin A, sekretuvar, oksijen tüketimi, menopoz sonrası, solunum yolu enfeksiyonu, tükürük/immünoloji

Kaynakça

• Adams PF, Benson V. Current estimates from the National Health Interview Survey, 1990. Vital Health Stat 10 1991;(181):1-212.
• Nicholson KG. Impact of influenza and respiratory syncytial virus on mortality in England and Wales from January 1975 to December 1990. Epidemiol Infect 1996;116:51-63.
• Ben-Yehuda A, Weksler ME. Immune senescence: mechanisms and clinical implications. Cancer Invest 1992;10:525-31.
• Woods J, Lu Q, Ceddia MA, Lowder T. Special feature for the Olympics: effects of exercise on the immune system: exercise-induced modulation of macrophage function. Immunol Cell Biol 2000;78:545-53.
• Akimoto T, Kumai Y, Akama T, Hayashi E, Murakami H, Soma R, et al. Effects of 12 months of exercise train- ing on salivary secretory IgA levels in elderly subjects. Br J Sports Med 2003;37:76-9.
• Nieman DC, Henson DA, Gusewitch G, Warren BJ, Dotson RC, Butterworth DE, et al. Physical activity and immune function in elderly women. Med Sci Sports Exerc 1993;25:823-31.
• Nieman DC. Exercise immunology: practical applica- tions. Int J Sports Med 1997;18 Suppl 1:S91-100.
• Nieman DC, Henson DA. Role of endurance exercise in immune senescence. Med Sci Sports Exerc 1994;26:172-81.
• Nieman DC, Nehlsen-Cannarella SL. The immune response to exercise. Semin Hematol 1994;31:166-79.
• Bruunsgaard H, Pedersen BK. Special feature for the Olympics: effects of exercise on the immune system: effects of exercise on the immune system in the elder- ly population. Immunol Cell Biol 2000;78:523-31.
• Jonsdottir IH. Special feature for the Olympics: effects of exercise on the immune system: neuropeptides and their interaction with exercise and immune function. Immunol Cell Biol 2000;78:562-70.
• Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adapta- tion. Physiol Rev 2000;80:1055-81.
• Rowbottom DG, Green KJ. Acute exercise effects on the immune system. Med Sci Sports Exerc 2000;32(7 Suppl):S396-405.
• Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR. Exercise and the incidence of upper res- piratory tract infections. Med Sci Sports Exerc 1991; 23:152-7.
• Konig D, Grathwohl D, Weinstock C, Northoff H, Berg A. Upper respiratory tract infection in athletes: influ- ence of lifestyle, type of sport, training effort, and immunostimulant intake. Exerc Immunol Rev 2000; 6:102-20.
• Linde F. Running and upper respiratory tract infec- tions. Scand J Sport Sci 1987;9:21-3.
• Nieman DC. Exercise, upper respiratory tract infec- tion, and the immune system. Med Sci Sports Exerc 1994;26:128-39.
• Nieman DC. Upper respiratory tract infections and exercise. Thorax 1995;50:1229-31.
• Nieman DC. Immune response to heavy exertion. J Appl Physiol 1997;82:1385-94.
• Nieman DC, Johanssen LM, Lee JW. Infectious episodes in runners before and after a roadrace. J Sports Med Phys Fitness 1989;29:289-96.
• Nieman DC, Johanssen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 1990; 30:316-28.
• Nieman DC. Special feature for the Olympics: effects of exercise on the immune system: exercise effects on systemic immunity. Immunol Cell Biol 2000;78:496- 501.
• Gleeson M, Pyne DB. Special feature for the Olympics: effects of exercise on the immune system: exercise effects on mucosal immunity. Immunol Cell Biol 2000; 78:536-44.
• Barriga C, Pedrera MI, Maynar M, Maynar J, Ortega E. Effect of submaximal physical exercise performed by sedentary men and women on some parameters of the immune system. Rev Esp Fisiol 1993;49:79-85.
• Crist DM, Mackinnon LT, Thompson RF, Atterbom HA, Egan PA. Physical exercise increases natural cel- lular-mediated tumor cytotoxicity in elderly women. Gerontology 1989;35:66-71.
• Fiatarone MA, Morley JE, Bloom ET, Benton D, Solomon GF, Makinodan T. The effect of exercise on natural killer cell activity in young and old subjects. J Gerontol 1989;44:M37-45.
• Nieman DC, Nehlsen-Cannarella SL, Markoff PA, Balk-Lamberton AJ, Yang H, Chritton DB, et al. The effects of moderate exercise training on natural killer cells and acute upper respiratory tract infections. Int J Sports Med 1990;11:467-73.
• Shinkai S, Konishi M, Shephard RJ. Aging, exercise, training, and the immune system. Exerc Immunol Rev 1997;3:68-95.
• MacKinnon LT, Jenkins DG. Decreased salivary immunoglobulins after intense interval exercise before and after training. Med Sci Sports Exerc 1993;25:678- 83.
• Kostka T, Berthouze SE, Lacour J, Bonnefoy M. The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sports Exerc 2000;32:46-51.