Prognostic factors and survival rates in oral cavity cancers

Yıl 2006, Cilt: 16 Sayı: 2, 64 - 71, 20.03.2006

Sercan C. Özyurt Gamze Uğurluer Ferdi Aksaray Nalan Aslan Rahşan Habiboğlu Mübeccel Tümöz

Öz

Objectives: We evaluated the treatment results and prognostic factors that might affect local control and survival in patients receiving radiotherapy for oral cavity cancers.Patients and Methods: The study included 32 patients 16 men, 16 women; mean age 62 years; range 26 to 90 years who received radiotherapy for oral cavity can­ cers. AH the patients had squamous celi carcinoma, which involved the tongue in 15 patients 46.9% and the lower lip in 13 patients 40.6% . Most of the patients n=21,65.7% had or T2 tumors. Neck lymph nodes were positive in 11 patients 34.4% . Fifteen patients had early stage stage I, II , 17 patients had advanced stage stage III, IV tumors. Sixteen patients received primary radiotherapy and 16 patients received postop- erative adjuvant radiotherapy, with doses ranging from 5000 cGy to 7000 cGy. The mean follow-up period was 68 months range 5 to 147 months .Results: Two-year and five-year survival rates were 53% and 39%, respectively. Age, sex, tumor differentiation, and the total radiotherapy dose were not found to affect survival p>0.05 , whereas tumor size, positive lymph nodes, stage, and treat­ ment modality were found as significant prognostic factors p=0.01 .Conclusion: Our data show that tumor size, lymph node involvement, stage, and postoperative adju­ vant radiotherapy are significant parameters that affect survival in oral cavity cancers.

Anahtar Kelimeler

Carcinoma, squamous cell/radiotherapy/ surgery, mouth neoplasms/radiotherapy/surgery, prognosis

Oral kavile kanserlerinde prognostik faktörler ve sağkalım oranları

Öz

Amaç: Oral kavite kanseri tanısıyla radyoterapi uygulanan hastalarda tedavi sonuçları, lokal kontrol vesağkalımı etkileyebilecek prognostik faktörler değerlendirildi.Hastalar ve Yöntemler: Oral kavite kanseri nedeniyle radyoterapi uygulanan 32 hasta çalışmaya alındı.Tüm hastalarda tümör yassı hücreli karsinomdu.On beş hastada %46.9 dil, 13 hastada %40.6 altdudak kanseri vardı. Hastaların çoğu T1, T2tümörle 21 hasta, %65.7 başvurmuştu; 11’inde %34.4 boyun lenf nodları pozitifti. On beş hasta erken evre evre I, II , 17 hasta ileri evredeydi evre III, IV .On altı hasta primer radyoterapi, 16 hasta ameliyatsonrası adjuvan radyoterapi ile tedavi görmüştü.Radyoterapi dozu 5000-7000 cGy arasında değişiyordu. Hastaların ortalama takip süresi 68 ay dağılım 5-147 ay idi.Bulgular: İki yıllık ve beş yıllık sağkalım oranları sırasıyla %53 ve %39 olarak hesaplandı. Yaş, cinsiyet, tümör diferansiasyonu ve toplam radyoterapidozunun sağkalımı anlamlı olarak etkilemediği görüldü p>0.05 . Tümör büyüklüğü, boyun lenf nodututulumu, evre ve tedavi yönteminin sağkalımı anlamlı etkilediği görüldü p=0.01 . Sonuç: Çalışmamızda tümör büyüklüğü, lenf nodututulumu, evre ve ameliyat sonrası adjuvan radyoterapi, oral kavite kanserlerinde sağkalımı anlamlı olarak etkileyen faktörler olarak bulundu

Anahtar Kelimeler

Karsinom, skuamöz hücreli/radyoterapi/cerrahi, ağız neoplazileri/radyoterapi/cerrahi, prognoz

Kaynakça

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