Serum nitric oxide levels in patients with head and neck squamous celi carcinoma

Yıl 2007, Cilt: 17 Sayı: 3, 148 - 151, 23.05.2007

Ahmet Kızılay Mahmut Tayyar Kalcıoğlu Fikret Özuğurlu Hüseyin Özyurt İbrahim Aladağ Orhan Özturan Ömer Akyol

Öz

Objectives: We determined serum nitric oxide NO levels in patients with head and neck squamous celi carcinoma SCO and sought correlations with TNM staging, tumor localization, and tumor grade.Patients and Methods: Serum samples were obtained from 36 patients mean age 63 years; range 37 to 80 years with head and neck SCO prior to treat- ment and from 20 healthy individuals mean age 56 years; range 30 to 72 years as Controls. Tumor stag­ ing was based on the criteria of the American Joint Committee of Cancer staging system in 2002. Thirteen patients had stage l-ll, and 23 patients had stage lll-IV tumors and ali had well- or moderately-differentiated SCO grade 1-2 . Serum NO levels were analyzed by a spectrophotometric method based on the determi- nation of total nitrite levels in serum and compared between the patient and control groups.Results: The mean serum NO levels were 20.08±1.40 pmol/l and 13.57±0.99 pmol/l in cancer patients and Controls, respectively p=0.001 . There were no correlations between NO levels and age, sex, tumor stage, localization, and histological grade.Conclusion: These data suggest that head and neck SCO is associated with increased serum NO levels, which may play a role in tumor growth.

Anahtar Kelimeler

Carcinoma, squamous cell/metabolism, head and neck neoplasms/metabolism, nitric oxide/blood, tumor markers, biological

Baş-boyun yassı epitel hücreli kanserli hastaların serumlarında nitrik oksit düzeyleri

Öz

Amaç: Baş-boyunda skuamöz hücreli kanser saptanan hastalarda serum nitrik oksit NO düzeyi belirlendi ve bunun TNM evresi, tümör yerleşimi ve derecelendirmesi ile ilişkisi araştırıldı.Hastalar ve Yöntemler: Baş-boyunda skuamözhücreli kanser tanısı konan 36 hastadan tedavi öncesinde ve kontrol olarak 20sağlıklı erişkinden serumörnekleri alındı. Tümör evrelemesi AJCC AmericanJoint Committee of Cancer 2002 ölçütlerine göreyapıldı. On üç hastada evre I-II, 23 hastada evre IIIIV tümör vardı. Tüm hastalarda tümör diferensiyasyonu iyi veya orta derecedeydi . SerumNO düzeylerinin analizi, serumda total nitritin saptanması esasına dayanan spektrofotometrik yöntemle yapıldı ve hasta ve kontrol gruplarının NO düzeyleri karşılaştırıldı.Bulgular: Kanserli grupta ve kontrol grubunda ortalama serum NO düzeyi sırasıyla 20.08±1.40 μmol/lve 13.57±0.99 μmol/l bulundu p=0.001 . Kanserligrupta NO düzeyi yaş, cinsiyet, tümör evresi, yerleşimi ve histolojik derecesi ile ilişkili bulunmadı.Sonuç: Bu veriler baş-boyundaki skuamöz hücreli kanserlerde serum NO düzeyinin arttığını göstermektedir.Bu aktivite artışı tümör büyümesinde rol oynayabilir

Anahtar Kelimeler

Karsinom, skuamöz hücreli/metabolizma, baş-boyun neoplazileri/metabolizma, nitrik oksit/kan, tümör belirteci, biyolojik

Kaynakça

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