BibTex RIS Kaynak Göster

Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report

Yıl 2007, Cilt: 17 Sayı: 3, 171 - 175, 23.05.2007

Öz

A 16-year-old male patient complained of right-sided tinnitus and mild deafness of one-month history. He also had a family history of neurofibromatosis type 2 and a history of a prior operation for left vestibular schwannoma a year ago. Otoneurologic examination revealed moderate sensorineural hearing loss.Magnetic resonance imaging demonstrated multiple extra-axial enhancing masses in the vicinity of both hypoglossal nerves, the right vestibular nerve, the left vestibular nerve, the right trigeminal, the left occulo- motor and the right abducens nerves. These findings were evaluated as multiple cranial nerve schwanno- mas. The case was considered a rare manifestation of neurofibromatosis type 2 without any concomitant abnormality in the central nervous system.Symptomatic medical treatment was initiated and the patient was referred to the neurosurgery department.

Kaynakça

  • Egelhoff JC, Bates DJ, Ross JS, Rothner AD, Cohen BH. Spinal MR findings in neurofibromatosis types 1 and 2. AJNR Am J Neuroradiol 1992;13:1071-7.
  • Evans DG, Huson SM, Donnai D, Neary W, Blair V, Newton V, et al. A clinical study of type 2 neurofibro- matosis. Q J Med 1992;84:603-18.
  • Halliday AL, Sobel RA, Martuza RL. Benign spinal nerve sheath tumors: their occurrence sporadically and in neurofibromatosis types 1 and 2. J Neurosurg 1991;74:248-53.
  • Mautner VF, Tatagiba M, Lindenau M, Funsterer C, Pulst SM, Baser ME, et al. Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity, and variety. AJR Am J Roentgenol 1995;165:951-5.
  • Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol 1988;45:575-8.
  • Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 1995;5:163-72.
  • Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Seizinger BR, et al. Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 1987;329:246-8.
  • Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, et al. The diagnostic evaluation and multi- disciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-7.
  • Parry DM, Eldridge R, Kaiser-Kupfer MI, Bouzas EA, Pikus A, Patronas N. Neurofibromatosis 2 (NF2): clin- ical characteristics of 63 affected individuals and clini- cal evidence for heterogeneity. Am J Med Genet 1994; 52:450-61.
  • Evans DG, Mason S, Huson SM, Ponder M, Harding AE, Strachan T. Spinal and cutaneous schwannomato- sis is a variant form of type 2 neurofibromatosis: a clin- ical and molecular study. J Neurol Neurosurg Psychiatry 1997;62:361-6.
  • Evans DG, Blair V, Strachan T, Lye RH, Ramsden RT. Variation of expression of the gene for type 2 neurofi- bromatosis: absence of a gender effect on vestibular schwannomas, but confirmation of a preponderance of meningiomas in females. J Laryngol Otol 1995;109:830-5.
  • Karamitopoulou E, Perentes E, Diamantis I, Maraziotis T. Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal anti- body on archival material. Acta Neuropathol 1994; 87:47-54.
  • Russell DS, Rubinstein LJ. Tumours of the cranial, spinal and peripheral nerve sheaths. In: Russel DS, Rubinstein LJ, editors. Pathology of the tumours of the nervous system. 5th ed. London: Edward Arnold; 1989. p. 533-89.
  • Woodruff JM, Kourea HP, Louis DN. Schwannoma. In: Kleihues P, Cavenee WK, editors. Pathology and genetics of tumours of the nervous system. Lyon: International Agency for Research on Cancer; 1997. p. 126-8.
  • Seppala M. Long-term outcome of surgery for spinal nerve sheath neoplasms [Dissertation]. University of Helsinki; 1998.
  • Kuratsu J, Ushio Y. Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto Prefecture in the southern part of Japan. J Neurosurg 1996;84:946-50.
  • Preston-Martin S. Descriptive epidemiology of prima- ry tumors of the brain, cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 1989;8:283-95.
  • Radhakrishnan K, Mokri B, Parisi JE, O’Fallon WM, Sunku J, Kurland LT. The trends in incidence of pri- mary brain tumors in the population of Rochester, Minnesota. Ann Neurol 1995;37:67-73.
  • Sobel RA. Vestibular (acoustic) schwannomas: histo- logic features in neurofibromatosis 2 and in unilateral cases. J Neuropathol Exp Neurol 1993;52:106-13.
  • Seppala MT, Sainio MA, Haltia MJ, Kinnunen JJ, Setala KH, Jaaskelainen JE. Multiple schwannomas: schwan- nomatosis or neurofibromatosis type 2? J Neurosurg 1998;89:36-41.
  • Minamino M, Iwai H, Yano J, Fujisawa T, Yamashita T. Neurofibromatosis type 2 associated with cranial nerve schwannomas. Otolaryngol Head Neck Surg 2001;124:581-3.
  • Suresh TN, Mahadevan A, Chandrashekhar Sagar B, Santosh V, Yasha TC, Shankar SK. Unusual case of mul- tiple cellular and malignant schwannomas of the cranial and spinal nerves. Clin Neuropathol 2003;22:23-9.
  • Kuchna I, Zabek M, Dambska M, Matyja E, Wierzba- Bobrowicz T. Neurofibromatosis type 2. Case report. Folia Neuropathol 1995;33:141-4.
  • Black FO, Brackmann DE, Hitselberger WE, Purdy J. Preservation of auditory and vestibular function after surgical removal of bilateral vestibular schwannomas in a patient with neurofibromatosis type 2. Am J Otol 1995;16:431-43.
  • Blomstedt GC, Jaaskelainen JE, Pyykko I, Ishizaki H, Troupp H, Palva T. Recovery of the sutured facial nerve after removal of acoustic neuroma in patients with neu- rofibromatosis-2. Neurosurgery 1994;35:364-8.
  • Samii M, Matthies C, Tatagiba M. Management of vestibular schwannomas (acoustic neuromas): audito- ry and facial nerve function after resection of 120 vestibular schwannomas in patients with neurofibro- matosis 2. Neurosurgery 1997;40:696-705.
  • Wigand ME, Haid T, Goertzen W, Wolf S. Preservation of hearing in bilateral acoustic neurinomas by deliber- ate partial resection. Acta Otolaryngol 1992;112:237-41.

Kraniyal sinir flivannomlar›n›n efllik etti¤i tip 2 nörofibromatozis: Olgu sunumu

Yıl 2007, Cilt: 17 Sayı: 3, 171 - 175, 23.05.2007

Öz

On altı yaşında erkek hasta, bir ay önce başlayan sağ taraflı kulak çınlaması ve hafif sağırlık yakın- malarıyla başvurdu. Aile öyküsünde nörofibromato- zis tip 2 bulunan hasta bir yıl önce sol vestibüler şivannom nedeniyle ameliyet geçirmişti. Otonörolo- jik muayenede orta derecede sensorinöral işitme kaybı saptandı. Manyetik rezonans görüntülemede, iki taraflı hipoglossal sinirler, sağ ve sol vestibüler sinirler, sağ trigeminal, sol okulomotor ve sağ ab- dusens sinirlerin komşuluğunda ekstra-aksiyel yer- leşim gösteren, kontrast tutan birçok kitle saptandı. Kitleler kraniyal sinir şivannomu olarak değerlendi- rildi. Bulgular, eşlik eden herhangi bir santral sinir sistemi anormalliğinin bulunmadığı, nörofibromato- zis tip 2’nin nadir görülen bir tablosu olarak kabul edildi. Semptomatik medikal tedaviye başlanan hasta beyin cerrahisi kliniğine sevk edildi

Kaynakça

  • Egelhoff JC, Bates DJ, Ross JS, Rothner AD, Cohen BH. Spinal MR findings in neurofibromatosis types 1 and 2. AJNR Am J Neuroradiol 1992;13:1071-7.
  • Evans DG, Huson SM, Donnai D, Neary W, Blair V, Newton V, et al. A clinical study of type 2 neurofibro- matosis. Q J Med 1992;84:603-18.
  • Halliday AL, Sobel RA, Martuza RL. Benign spinal nerve sheath tumors: their occurrence sporadically and in neurofibromatosis types 1 and 2. J Neurosurg 1991;74:248-53.
  • Mautner VF, Tatagiba M, Lindenau M, Funsterer C, Pulst SM, Baser ME, et al. Spinal tumors in patients with neurofibromatosis type 2: MR imaging study of frequency, multiplicity, and variety. AJR Am J Roentgenol 1995;165:951-5.
  • Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference. Arch Neurol 1988;45:575-8.
  • Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 1995;5:163-72.
  • Rouleau GA, Wertelecki W, Haines JL, Hobbs WJ, Trofatter JA, Seizinger BR, et al. Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22. Nature 1987;329:246-8.
  • Gutmann DH, Aylsworth A, Carey JC, Korf B, Marks J, Pyeritz RE, et al. The diagnostic evaluation and multi- disciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997;278:51-7.
  • Parry DM, Eldridge R, Kaiser-Kupfer MI, Bouzas EA, Pikus A, Patronas N. Neurofibromatosis 2 (NF2): clin- ical characteristics of 63 affected individuals and clini- cal evidence for heterogeneity. Am J Med Genet 1994; 52:450-61.
  • Evans DG, Mason S, Huson SM, Ponder M, Harding AE, Strachan T. Spinal and cutaneous schwannomato- sis is a variant form of type 2 neurofibromatosis: a clin- ical and molecular study. J Neurol Neurosurg Psychiatry 1997;62:361-6.
  • Evans DG, Blair V, Strachan T, Lye RH, Ramsden RT. Variation of expression of the gene for type 2 neurofi- bromatosis: absence of a gender effect on vestibular schwannomas, but confirmation of a preponderance of meningiomas in females. J Laryngol Otol 1995;109:830-5.
  • Karamitopoulou E, Perentes E, Diamantis I, Maraziotis T. Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal anti- body on archival material. Acta Neuropathol 1994; 87:47-54.
  • Russell DS, Rubinstein LJ. Tumours of the cranial, spinal and peripheral nerve sheaths. In: Russel DS, Rubinstein LJ, editors. Pathology of the tumours of the nervous system. 5th ed. London: Edward Arnold; 1989. p. 533-89.
  • Woodruff JM, Kourea HP, Louis DN. Schwannoma. In: Kleihues P, Cavenee WK, editors. Pathology and genetics of tumours of the nervous system. Lyon: International Agency for Research on Cancer; 1997. p. 126-8.
  • Seppala M. Long-term outcome of surgery for spinal nerve sheath neoplasms [Dissertation]. University of Helsinki; 1998.
  • Kuratsu J, Ushio Y. Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto Prefecture in the southern part of Japan. J Neurosurg 1996;84:946-50.
  • Preston-Martin S. Descriptive epidemiology of prima- ry tumors of the brain, cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 1989;8:283-95.
  • Radhakrishnan K, Mokri B, Parisi JE, O’Fallon WM, Sunku J, Kurland LT. The trends in incidence of pri- mary brain tumors in the population of Rochester, Minnesota. Ann Neurol 1995;37:67-73.
  • Sobel RA. Vestibular (acoustic) schwannomas: histo- logic features in neurofibromatosis 2 and in unilateral cases. J Neuropathol Exp Neurol 1993;52:106-13.
  • Seppala MT, Sainio MA, Haltia MJ, Kinnunen JJ, Setala KH, Jaaskelainen JE. Multiple schwannomas: schwan- nomatosis or neurofibromatosis type 2? J Neurosurg 1998;89:36-41.
  • Minamino M, Iwai H, Yano J, Fujisawa T, Yamashita T. Neurofibromatosis type 2 associated with cranial nerve schwannomas. Otolaryngol Head Neck Surg 2001;124:581-3.
  • Suresh TN, Mahadevan A, Chandrashekhar Sagar B, Santosh V, Yasha TC, Shankar SK. Unusual case of mul- tiple cellular and malignant schwannomas of the cranial and spinal nerves. Clin Neuropathol 2003;22:23-9.
  • Kuchna I, Zabek M, Dambska M, Matyja E, Wierzba- Bobrowicz T. Neurofibromatosis type 2. Case report. Folia Neuropathol 1995;33:141-4.
  • Black FO, Brackmann DE, Hitselberger WE, Purdy J. Preservation of auditory and vestibular function after surgical removal of bilateral vestibular schwannomas in a patient with neurofibromatosis type 2. Am J Otol 1995;16:431-43.
  • Blomstedt GC, Jaaskelainen JE, Pyykko I, Ishizaki H, Troupp H, Palva T. Recovery of the sutured facial nerve after removal of acoustic neuroma in patients with neu- rofibromatosis-2. Neurosurgery 1994;35:364-8.
  • Samii M, Matthies C, Tatagiba M. Management of vestibular schwannomas (acoustic neuromas): audito- ry and facial nerve function after resection of 120 vestibular schwannomas in patients with neurofibro- matosis 2. Neurosurgery 1997;40:696-705.
  • Wigand ME, Haid T, Goertzen W, Wolf S. Preservation of hearing in bilateral acoustic neurinomas by deliber- ate partial resection. Acta Otolaryngol 1992;112:237-41.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Olgu Sunumu
Yazarlar

Ahmet Mesrur Halefoğlu Bu kişi benim

Yayımlanma Tarihi 23 Mayıs 2007
Yayımlandığı Sayı Yıl 2007 Cilt: 17 Sayı: 3

Kaynak Göster

APA Halefoğlu, A. M. (2007). Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. The Turkish Journal of Ear Nose and Throat, 17(3), 171-175.
AMA Halefoğlu AM. Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Tr-ENT. Mayıs 2007;17(3):171-175.
Chicago Halefoğlu, Ahmet Mesrur. “Neurofibromatosis Type 2 Associated With Multiple Cranial Nerve Schwannomas: A Case Report”. The Turkish Journal of Ear Nose and Throat 17, sy. 3 (Mayıs 2007): 171-75.
EndNote Halefoğlu AM (01 Mayıs 2007) Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. The Turkish Journal of Ear Nose and Throat 17 3 171–175.
IEEE A. M. Halefoğlu, “Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report”, Tr-ENT, c. 17, sy. 3, ss. 171–175, 2007.
ISNAD Halefoğlu, Ahmet Mesrur. “Neurofibromatosis Type 2 Associated With Multiple Cranial Nerve Schwannomas: A Case Report”. The Turkish Journal of Ear Nose and Throat 17/3 (Mayıs 2007), 171-175.
JAMA Halefoğlu AM. Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Tr-ENT. 2007;17:171–175.
MLA Halefoğlu, Ahmet Mesrur. “Neurofibromatosis Type 2 Associated With Multiple Cranial Nerve Schwannomas: A Case Report”. The Turkish Journal of Ear Nose and Throat, c. 17, sy. 3, 2007, ss. 171-5.
Vancouver Halefoğlu AM. Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Tr-ENT. 2007;17(3):171-5.