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Tuberculous lymphadenitis

Yıl 2010, Cilt: 20 Sayı: 4, 184 - 190, 20.08.2010

Öz

Objectives: In this study, we evaluate tuberculosis Tbc lymphadenitis diagnosed patients age, gender, contact history, history of smoking, socioeconomic status, lymphadenitis localization, imaging techniques, fine needle aspiration biopsy FNAB and excisional biopsy results. Patients and Methods: Between February 2006 and February 2008 104 patients were operated to determine the etiology of their neck masses. Twenty-six patients 16 females, 10 males; mean age 36.9 years; range 16 to 52 years who were diagnosed as Tbc lymphadenitis according to pathology results were included in the study. Ear, nose and throat examinations were performed in all patients routinely. Hemogram, biochemical and serological tests were performed. The patients were evaluated with anterior-posterior chest radiographs and purified protein derivative PPD by chest diseases consultation imaging methods and FNAB was performed. All patients diagnosed with excisional biopsy of neck mass. During the operation, tissue culture and ZiehlNeelsen method for staining was prepared. Results: Out of 26 patients eight had a history of contact with Tbc. One person had previously lung Tbc. Six patients had previously received treatment because of Tbc lymphadenitis, but didn’t complete the treatment. Neck ultrasonography and neck computed tomography detected a solid mass in 16 patients and cystic mass in 10 patients. The 24 patients were evaluated as positive PPD >10 mm . None of the patients had an association between active pulmonary Tbc and Tbc lymphadenitis. Conclusion: Suspicion is the most important step in the diagnosis of Tbc lymphadenitis. In patients with low socioeconomic status, previous Tbc contact, tabacco usage, suppressed immune system, and particularly in those with drainage from neck masses, Tbc lymphadenitis should be considered in the differential diagnosis.

Kaynakça

  • Baatenburg de Jong RJ, Rongen RJ, Laméris JS, Knegt P, Verwoerd CD. Ultrasound in the diagnosis of cer- vical tuberculous adenitis. Auris Nasus Larynx 1998; 25:67-72.
  • Roberts DS, Dowdall JR, Winter L, Sulis CA, Grillone GA, Grundfast KM. Cervical tuberculosis: a decision tree for protecting healthcare workers. Laryngoscope 2008;118:1345-9.
  • Chao SS, Loh KS, Tan KK, Chong SM. Tuberculous and nontuberculous cervical lymphadenitis: a clinical review. Otolaryngol Head Neck Surg 2002;126:176-9.
  • Cheng AG, Chang A, Farwell DG, Agoff SN. Auramine orange stain with fluorescence microscopy is a rapid and sensitive technique for the detection of cer- vical lymphadenitis due to mycobacterial infection using fine needle aspiration cytology: a case series. Otolaryngol Head Neck Surg 2005;133:381-5.
  • Munck K, Mandpe AH. Mycobacterial infections of the head and neck. Otolaryngol Clin North Am 2003;36:569-76.
  • Global tuberculosis control: surveillance, planning, financing. WHO report 2008. Geneva, World Health Organization, 2008 (WHO/HTM/TB/2008.393).
  • Agada FO, Sharma R, Makura ZG. Atypical presenta- tion of cutaneous tuberculosis and a retropharyngeal neck abscess. Ear Nose Throat J 2006;85:60-2.
  • Vaamonde P, Castro C, García-Soto N, Labella T, Lozano A. Tuberculous otitis media: a significant diagnostic challenge. Otolaryngol Head Neck Surg 2004;130:759-66.
  • Nalini B, Vinayak S. Tuberculosis in ear, nose, and throat practice: its presentation and diagnosis. Am J Otolaryngol 2006;27:39-45.
  • Lee IK, Liu JW. Tuberculous parotitis: case report and literature review. Ann Otol Rhinol Laryngol 2005; 114:547-51.
  • Williams RG, Douglas-Jones T. Mycobacterium march- es back. J Laryngol Otol 1995;109:5-13.
  • Mandpe AH, Lee KC. Tuberculous infections of the head and neck. Current Opinion in Otolaryngology and Head and Neck Surg 1998;6:190-3.
  • Ibekwe AO, al Shareef Z, al Kindy S. Diagnostic prob- lems of tuberculous cervical adenitis (scrofula). Am J Otolaryngol 1997;18:202-5.
  • Je BK, Kim MJ, Kim SB, Park DW, Kim TK, Lee NJ. Detailed nodal features of cervical tuberculous lymphadenitis on serial neck computed tomography before and after chemotherapy: focus on the relation between clinical outcomes and computed tomography features. J Comput Assist Tomogr 2005;29:889-94.
  • Ammari FF, Bani Hani AH, Ghariebeh KI. Tuberculosis of the lymph glands of the neck: a limited role for sur- gery. Otolaryngol Head Neck Surg 2003;128:576-80.
  • Wang CC, Lin CC, Wang CP, Liu SA, Jiang RS. Laryngeal tuberculosis: a review of 26 cases. Otolaryngol Head Neck Surg 2007;137:582-8.
  • Tse GM, Ma TK, Chan AB, Ho FN, King AD, Fung KS, et al. Tuberculosis of the nasopharynx: a rare entity revisited. Laryngoscope 2003;113:737-40.
  • Menon K, Bem C, Gouldesbrough D, Strachan DR. A clinical review of 128 cases of head and neck tubercu- losis presenting over a 10-year period in Bradford, UK. J Laryngol Otol 2007;121:362-8.
  • Weiler Z, Nelly P, Baruchin AM, Oren S. Diagnosis and treatment of cervical tuberculous lymphadenitis. J Oral Maxillofac Surg 2000;58:477-81.
  • Chan AB, Ma TK, Yu BK, King AD, Ho FN, Tse GM. Nasopharyngeal granulomatous inflammation and tuberculosis complicating undifferentiated carcinoma. Otolaryngol Head Neck Surg 2004;130:125-30.
  • Srirompotong S, Yimtae K, Jintakanon D. Nasopharyngeal tuberculosis: manifestations between 1991 and 2000. Otolaryngol Head Neck Surg 2004;131:762-4.
  • Deitel M, Bendago M, Krajden S, Ronald AC, Borowy ZJ. Modern management of cervical scrofula. Head Neck 1989;11:60-6.
  • Martin P. The tuberculin skin test. N Z Med J 1994; 107:310-1.
  • Dangore SB, Degwekar SS, Bhowate RR. Evaluation of the efficacy of colour Doppler ultrasound in diagnosis of cervical lymphadenopathy. Dentomaxillofac Radiol 2008;37:205-12.
  • Enomoto K, Hoshida Y, Hamada K, Okada T, Kubo T, Hatazawa J. F-18 FDG PET imaging of cervical tuberculous lymphadenitis. Clin Nucl Med 2007;32:474-5.
  • van Loenhout-Rooyackers JH, Laheij RJ, Richter C, Verbeek AL. Shortening the duration of treatment for cervical tuberculous lymphadenitis. Eur Respir J 2000;15:192-5.
  • Khan J, Akhtar M, von Sinner WN, Bouchama A, Bazarbashi M. CT-guided fine needle aspiration biop- sy in the diagnosis of mediastinal tuberculosis. Chest 1994;106:1329-32.
  • Thompson MM, Underwood MJ, Sayers RD, Dookeran KA, Bell PR. Peripheral tuberculous lymphadenopa- thy: a review of 67 cases. Br J Surg 1992;79:763-4.
  • Baek CH, Kim SI, Ko YH, Chu KC. Polymerase chain reaction detection of mycobacterium tuberculosis from fine-needle aspirate for the diagnosis of cervical tuber- culous lymphadenitis. Laryngoscope 2000;110:30-4.
  • Schneider K, Vetter W, Steurer J. Diagnosis and ther- apy of lymph node tuberculosis. Praxis (Bern 1994) 1999;88:105-12. [Abstract]
  • Lau SK, Wei WI, Hsu C, Engzell UC. Efficacy of fine needle aspiration cytology in the diagnosis of tubercu- lous cervical lymphadenopathy. J Laryngol Otol 1990; 104:24-7.
  • Yuen AP, Wong SH, Tam CM, Chan SL, Wei WI, Lau SK. Prospective randomized study of thrice weekly six-month and nine-month chemotherapy for cervi- cal tuberculous lymphadenopathy. Otolaryngol Head Neck Surg 1997;116:189-92.

Tüberküloz lenfadenitleri

Yıl 2010, Cilt: 20 Sayı: 4, 184 - 190, 20.08.2010

Öz

Amaç: Bu çalışmada tüberküloz Tbc lenfadenit tanısı konulan hastaların yaşı, cinsiyeti, temas öyküsü, sigara öyküsü, sosyoekonomik durumu, lenfadenitin yerleşim yeri, görüntüleme yöntemleri, ince iğne aspirasyon biyopsisi İİAB ve eksizyonel biyopsi sonuçları değerlendirildi.Hastalar ve Yöntemler: Şubat 2006 ile Şubat 2008 tarihleri arasında 104 hasta boyun kitlelerinin etyolojisinin saptanması amacı ile ameliyat edildi. Patoloji sonucunda Tbc lenfadenit tanısı konulan 26 hasta 16 kadın, 10 erkek; ort. yaş 36.9 yıl; dağılım 16-52 yıl çalışmaya dahil edildi. Bütün hastaların kulak burun boğaz muayeneleri rutin olarak yapıldı. Hemogram, biyokimya ve serolojik testleri yapıldı. Hastalar ön-arka akciğer grafileri, PPD Purified protein derivative ve göğüs hastalıkları konsültasyonu görüntüleme yöntemleri ile İİAB yapılarak değerlendirildi. Tüm hastalara tanı boyun kitlesinden yapılan eksizyonel biyopsi ile konuldu. Ameliyat sırasında Ziehl-Neelsen yöntemiyle boyama ve doku kültürü için materyal alındı.Bulgular: Yirmi altı hastanın sekizinde Tbc ile temas öyküsü vardı. Bir kişi daha önce akciğer Tbc’si geçirmişti. Altı hasta daha önce Tbc lenfadeniti nedeni ile tedavi almış ancak tedavisini tamamlamamıştı. Boyun ultrasonografisi ve boyun bilgisayarlı tomografisinde hastaların 16’sında solid 10’unda ise kistik kitle saptandı. Yirmi dört hasta ise pozitif PPD olarak >10 mm değerlendirildi. Hastaların hiçbirinde Tbc lenfadenitle aktif akciğer Tbc birlikteliği saptanmadı.Sonuç: Şüphe Tbc lenfadenitinin tanısında en önemli adımdır. Sosyoekonomik durumu kötü olan daha önce Tbc temas öyküsü olan, sigara kullanan, immün sistemi baskılanmış olan hastalarda ve özellikle boyun kitlesinden akıntı tanımlayanlarda Tbc lenfadenit, ayırıcı tanıda düşünülmelidir

Kaynakça

  • Baatenburg de Jong RJ, Rongen RJ, Laméris JS, Knegt P, Verwoerd CD. Ultrasound in the diagnosis of cer- vical tuberculous adenitis. Auris Nasus Larynx 1998; 25:67-72.
  • Roberts DS, Dowdall JR, Winter L, Sulis CA, Grillone GA, Grundfast KM. Cervical tuberculosis: a decision tree for protecting healthcare workers. Laryngoscope 2008;118:1345-9.
  • Chao SS, Loh KS, Tan KK, Chong SM. Tuberculous and nontuberculous cervical lymphadenitis: a clinical review. Otolaryngol Head Neck Surg 2002;126:176-9.
  • Cheng AG, Chang A, Farwell DG, Agoff SN. Auramine orange stain with fluorescence microscopy is a rapid and sensitive technique for the detection of cer- vical lymphadenitis due to mycobacterial infection using fine needle aspiration cytology: a case series. Otolaryngol Head Neck Surg 2005;133:381-5.
  • Munck K, Mandpe AH. Mycobacterial infections of the head and neck. Otolaryngol Clin North Am 2003;36:569-76.
  • Global tuberculosis control: surveillance, planning, financing. WHO report 2008. Geneva, World Health Organization, 2008 (WHO/HTM/TB/2008.393).
  • Agada FO, Sharma R, Makura ZG. Atypical presenta- tion of cutaneous tuberculosis and a retropharyngeal neck abscess. Ear Nose Throat J 2006;85:60-2.
  • Vaamonde P, Castro C, García-Soto N, Labella T, Lozano A. Tuberculous otitis media: a significant diagnostic challenge. Otolaryngol Head Neck Surg 2004;130:759-66.
  • Nalini B, Vinayak S. Tuberculosis in ear, nose, and throat practice: its presentation and diagnosis. Am J Otolaryngol 2006;27:39-45.
  • Lee IK, Liu JW. Tuberculous parotitis: case report and literature review. Ann Otol Rhinol Laryngol 2005; 114:547-51.
  • Williams RG, Douglas-Jones T. Mycobacterium march- es back. J Laryngol Otol 1995;109:5-13.
  • Mandpe AH, Lee KC. Tuberculous infections of the head and neck. Current Opinion in Otolaryngology and Head and Neck Surg 1998;6:190-3.
  • Ibekwe AO, al Shareef Z, al Kindy S. Diagnostic prob- lems of tuberculous cervical adenitis (scrofula). Am J Otolaryngol 1997;18:202-5.
  • Je BK, Kim MJ, Kim SB, Park DW, Kim TK, Lee NJ. Detailed nodal features of cervical tuberculous lymphadenitis on serial neck computed tomography before and after chemotherapy: focus on the relation between clinical outcomes and computed tomography features. J Comput Assist Tomogr 2005;29:889-94.
  • Ammari FF, Bani Hani AH, Ghariebeh KI. Tuberculosis of the lymph glands of the neck: a limited role for sur- gery. Otolaryngol Head Neck Surg 2003;128:576-80.
  • Wang CC, Lin CC, Wang CP, Liu SA, Jiang RS. Laryngeal tuberculosis: a review of 26 cases. Otolaryngol Head Neck Surg 2007;137:582-8.
  • Tse GM, Ma TK, Chan AB, Ho FN, King AD, Fung KS, et al. Tuberculosis of the nasopharynx: a rare entity revisited. Laryngoscope 2003;113:737-40.
  • Menon K, Bem C, Gouldesbrough D, Strachan DR. A clinical review of 128 cases of head and neck tubercu- losis presenting over a 10-year period in Bradford, UK. J Laryngol Otol 2007;121:362-8.
  • Weiler Z, Nelly P, Baruchin AM, Oren S. Diagnosis and treatment of cervical tuberculous lymphadenitis. J Oral Maxillofac Surg 2000;58:477-81.
  • Chan AB, Ma TK, Yu BK, King AD, Ho FN, Tse GM. Nasopharyngeal granulomatous inflammation and tuberculosis complicating undifferentiated carcinoma. Otolaryngol Head Neck Surg 2004;130:125-30.
  • Srirompotong S, Yimtae K, Jintakanon D. Nasopharyngeal tuberculosis: manifestations between 1991 and 2000. Otolaryngol Head Neck Surg 2004;131:762-4.
  • Deitel M, Bendago M, Krajden S, Ronald AC, Borowy ZJ. Modern management of cervical scrofula. Head Neck 1989;11:60-6.
  • Martin P. The tuberculin skin test. N Z Med J 1994; 107:310-1.
  • Dangore SB, Degwekar SS, Bhowate RR. Evaluation of the efficacy of colour Doppler ultrasound in diagnosis of cervical lymphadenopathy. Dentomaxillofac Radiol 2008;37:205-12.
  • Enomoto K, Hoshida Y, Hamada K, Okada T, Kubo T, Hatazawa J. F-18 FDG PET imaging of cervical tuberculous lymphadenitis. Clin Nucl Med 2007;32:474-5.
  • van Loenhout-Rooyackers JH, Laheij RJ, Richter C, Verbeek AL. Shortening the duration of treatment for cervical tuberculous lymphadenitis. Eur Respir J 2000;15:192-5.
  • Khan J, Akhtar M, von Sinner WN, Bouchama A, Bazarbashi M. CT-guided fine needle aspiration biop- sy in the diagnosis of mediastinal tuberculosis. Chest 1994;106:1329-32.
  • Thompson MM, Underwood MJ, Sayers RD, Dookeran KA, Bell PR. Peripheral tuberculous lymphadenopa- thy: a review of 67 cases. Br J Surg 1992;79:763-4.
  • Baek CH, Kim SI, Ko YH, Chu KC. Polymerase chain reaction detection of mycobacterium tuberculosis from fine-needle aspirate for the diagnosis of cervical tuber- culous lymphadenitis. Laryngoscope 2000;110:30-4.
  • Schneider K, Vetter W, Steurer J. Diagnosis and ther- apy of lymph node tuberculosis. Praxis (Bern 1994) 1999;88:105-12. [Abstract]
  • Lau SK, Wei WI, Hsu C, Engzell UC. Efficacy of fine needle aspiration cytology in the diagnosis of tubercu- lous cervical lymphadenopathy. J Laryngol Otol 1990; 104:24-7.
  • Yuen AP, Wong SH, Tam CM, Chan SL, Wei WI, Lau SK. Prospective randomized study of thrice weekly six-month and nine-month chemotherapy for cervi- cal tuberculous lymphadenopathy. Otolaryngol Head Neck Surg 1997;116:189-92.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Makalesi
Yazarlar

İbrahim Sayın Bu kişi benim

Sultan Bişkin Bu kişi benim

Taliye Çakabay Bu kişi benim

Zahide Mine Yazıcı Bu kişi benim

Ayşenur Meriç Bu kişi benim

Fatma Tülin Kayhan Bu kişi benim

Yayımlanma Tarihi 20 Ağustos 2010
Yayımlandığı Sayı Yıl 2010 Cilt: 20 Sayı: 4

Kaynak Göster

APA Sayın, İ., Bişkin, S., Çakabay, T., Yazıcı, Z. M., vd. (2010). Tüberküloz lenfadenitleri. The Turkish Journal of Ear Nose and Throat, 20(4), 184-190.
AMA Sayın İ, Bişkin S, Çakabay T, Yazıcı ZM, Meriç A, Kayhan FT. Tüberküloz lenfadenitleri. Tr-ENT. Ağustos 2010;20(4):184-190.
Chicago Sayın, İbrahim, Sultan Bişkin, Taliye Çakabay, Zahide Mine Yazıcı, Ayşenur Meriç, ve Fatma Tülin Kayhan. “Tüberküloz Lenfadenitleri”. The Turkish Journal of Ear Nose and Throat 20, sy. 4 (Ağustos 2010): 184-90.
EndNote Sayın İ, Bişkin S, Çakabay T, Yazıcı ZM, Meriç A, Kayhan FT (01 Ağustos 2010) Tüberküloz lenfadenitleri. The Turkish Journal of Ear Nose and Throat 20 4 184–190.
IEEE İ. Sayın, S. Bişkin, T. Çakabay, Z. M. Yazıcı, A. Meriç, ve F. T. Kayhan, “Tüberküloz lenfadenitleri”, Tr-ENT, c. 20, sy. 4, ss. 184–190, 2010.
ISNAD Sayın, İbrahim vd. “Tüberküloz Lenfadenitleri”. The Turkish Journal of Ear Nose and Throat 20/4 (Ağustos 2010), 184-190.
JAMA Sayın İ, Bişkin S, Çakabay T, Yazıcı ZM, Meriç A, Kayhan FT. Tüberküloz lenfadenitleri. Tr-ENT. 2010;20:184–190.
MLA Sayın, İbrahim vd. “Tüberküloz Lenfadenitleri”. The Turkish Journal of Ear Nose and Throat, c. 20, sy. 4, 2010, ss. 184-90.
Vancouver Sayın İ, Bişkin S, Çakabay T, Yazıcı ZM, Meriç A, Kayhan FT. Tüberküloz lenfadenitleri. Tr-ENT. 2010;20(4):184-90.