BibTex RIS Kaynak Göster

The relationship between platelet count and mean platelet volume with obstructive sleep apnea syndrome

Yıl 2015, Cilt: 25 Sayı: 5, 289 - 294, 10.10.2015

Öz

Objectives: This study aims to investigate the relationship between platelet count and mean platelet volume MPV with obstructive sleep apnea syndrome OSAS . Patients and Methods: This retrospective study included 417 OSAS patients 284 males, 133 females; mean age 47.9±10.0; range 23 to 75 years who were performed polisomnography PSG in our clinic between January 2013 and December 2014. Patients were divided into two groups according to apnea-hipopnea index AHI . Apnea-hipopnea index <5 was assumed as normal, while AHI ≥5 was assumed as OSAS. Platelet count and MPV values of group with normal AHI and group with OSAS were statistically compared. Apneahipopnea index, REM AHI, non-REM AHI, minimum oxygen saturation, and duration of oxygen saturation remaining below 90% were statistically compared with platelet count and MPV. Results: The mean of platelet count in non-OSAS and OSAS groups were 262.31±65.78 and 252.77±61.86, respectively, with no statistically significant difference between the groups. Mean platelet volume in non-OSAS and OSAS groups were 9.56±1.88 and 9.71±1.57, respectively; however, the difference was not statistically significant. Platelet count increased statistically significantly as AHI, REM AHI, non-REM AHI, and minimum oxygen saturation parameters got impaired. Conclusion: As PSG parameters get impaired, platelet count increases in OSAS patients.

Kaynakça

  • Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597-619.
  • Köktürk O, Tatlicioglu T, Kemaloğlu Y, Fırat H, Çetin N. Habituel horlaması olan olgularda obstrüktif sleep apne sendromu prevelansı. Tüberkülöz ve Toraks Dergisi 1997;45:7-11.
  • Unnikrishnan D, Jun J, Polotsky V. Inflammation in sleep apnea: an update. Rev Endocr Metab Disord 2015;16:25-34.
  • Williams A, Scharf SM. Obstructive sleep apnea, cardiovascular disease, and inflammation--is NF-kappaB the key? Sleep Breath 2007;11:69-76.
  • Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-90.
  • Hla KM, Young T, Hagen EW, Stein JH, Finn LA, Nieto FJ, et al. Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study Sleep 2015;38:677-84.
  • Varol E, Ozturk O, Gonca T, Has M, Ozaydin M, Erdogan D, et al. Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest 2010;70:497-502.
  • Sökücü SN, Ozdemir C, Dalar L, Karasulu L, Aydın S, Altın S. Is mean platelet volume really a severity marker for obstructive sleep apnea syndrome without comorbidities? Pulm Med 2014;2014:754839.
  • Young T, Palta M, Dempsey J, Peppard PE, Nieto FJ, Hla KM. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ 2009;108:246-9.
  • Huang KT, Chin CH, Tseng CC, Chang HC, Chen YC, Wang CC, et al. The influence of obesity on different genders in patients with obstructive sleep apnea. ScientificWorldJournal 2014;2014:487215.
  • Ciccone MM, Scicchitano P, Zito A, Cortese F, Boninfante B, Falcone VA, et al. Correlation between inflammatory markers of atherosclerosis and carotid intima-media thickness in Obstructive Sleep Apnea. Molecules 2014;19:1651-62.
  • Akgul O, Uyarel H, Pusuroglu H, Gul M, Isiksacan N, Turen S, et al. Prognostic value of elevated mean platelet volume in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Acta Cardiol 2013;68:307-14.
  • Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scand J Clin Lab Invest 2011;71:163-7.
  • Biljak VR, Pancirov D, Cepelak I, Popović-Grle S, Stjepanović G, Grubišić TŽ. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Platelets 2011;22:466-70.
  • Erden EŞ, Yengil E, Tuncel E, Bilgiç HK, Demirköse M, Motor S ve ark. OSAS ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. JCEI 2013;4:492-6.
  • Gunbatar H, Sertogullarindan B, Ekin S, Akdag S, Arisoy A, Sayhan H. The correlation between red blood cell distribution width levels with the severity of obstructive sleep apnea and carotid intima media thickness. Med Sci Monit 2014;20:2199-204.

Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi

Yıl 2015, Cilt: 25 Sayı: 5, 289 - 294, 10.10.2015

Öz

Amaç: Bu çalışmada trombosit sayısı ve ortalama trombosit hacmi OTH ile tıkayıcı uyku apne sendromu TUAS arasındaki ilişki araştırıldı.Hastalar ve Yöntemler: Bu retrospektif çalışmaya Ocak 2013 - Aralık 2014 tarihleri arasında kliniğimizde polisomnografi PSG yapılan 417 TUAS hastası 284 erkek, 133 kadın; ort. yaş 47.9±10.0; dağılım 23-75 yıl dahil edildi. Hastalar apne hipopne indeksine AHİ göre iki gruba ayrıldı. Apne hipopne indeksi

Kaynakça

  • Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597-619.
  • Köktürk O, Tatlicioglu T, Kemaloğlu Y, Fırat H, Çetin N. Habituel horlaması olan olgularda obstrüktif sleep apne sendromu prevelansı. Tüberkülöz ve Toraks Dergisi 1997;45:7-11.
  • Unnikrishnan D, Jun J, Polotsky V. Inflammation in sleep apnea: an update. Rev Endocr Metab Disord 2015;16:25-34.
  • Williams A, Scharf SM. Obstructive sleep apnea, cardiovascular disease, and inflammation--is NF-kappaB the key? Sleep Breath 2007;11:69-76.
  • Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-90.
  • Hla KM, Young T, Hagen EW, Stein JH, Finn LA, Nieto FJ, et al. Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study Sleep 2015;38:677-84.
  • Varol E, Ozturk O, Gonca T, Has M, Ozaydin M, Erdogan D, et al. Mean platelet volume is increased in patients with severe obstructive sleep apnea. Scand J Clin Lab Invest 2010;70:497-502.
  • Sökücü SN, Ozdemir C, Dalar L, Karasulu L, Aydın S, Altın S. Is mean platelet volume really a severity marker for obstructive sleep apnea syndrome without comorbidities? Pulm Med 2014;2014:754839.
  • Young T, Palta M, Dempsey J, Peppard PE, Nieto FJ, Hla KM. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ 2009;108:246-9.
  • Huang KT, Chin CH, Tseng CC, Chang HC, Chen YC, Wang CC, et al. The influence of obesity on different genders in patients with obstructive sleep apnea. ScientificWorldJournal 2014;2014:487215.
  • Ciccone MM, Scicchitano P, Zito A, Cortese F, Boninfante B, Falcone VA, et al. Correlation between inflammatory markers of atherosclerosis and carotid intima-media thickness in Obstructive Sleep Apnea. Molecules 2014;19:1651-62.
  • Akgul O, Uyarel H, Pusuroglu H, Gul M, Isiksacan N, Turen S, et al. Prognostic value of elevated mean platelet volume in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Acta Cardiol 2013;68:307-14.
  • Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scand J Clin Lab Invest 2011;71:163-7.
  • Biljak VR, Pancirov D, Cepelak I, Popović-Grle S, Stjepanović G, Grubišić TŽ. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Platelets 2011;22:466-70.
  • Erden EŞ, Yengil E, Tuncel E, Bilgiç HK, Demirköse M, Motor S ve ark. OSAS ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. JCEI 2013;4:492-6.
  • Gunbatar H, Sertogullarindan B, Ekin S, Akdag S, Arisoy A, Sayhan H. The correlation between red blood cell distribution width levels with the severity of obstructive sleep apnea and carotid intima media thickness. Med Sci Monit 2014;20:2199-204.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Makalesi
Yazarlar

Doğan Atan Bu kişi benim

Fatma Cemre Sazak Kundi Bu kişi benim

Kürşat Murat Özcan Bu kişi benim

Hüseyin Dere Bu kişi benim

Yayımlanma Tarihi 10 Ekim 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 25 Sayı: 5

Kaynak Göster

APA Atan, D., Sazak Kundi, F. C., Özcan, K. M., Dere, H. (2015). Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi. The Turkish Journal of Ear Nose and Throat, 25(5), 289-294.
AMA Atan D, Sazak Kundi FC, Özcan KM, Dere H. Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi. Tr-ENT. Ekim 2015;25(5):289-294.
Chicago Atan, Doğan, Fatma Cemre Sazak Kundi, Kürşat Murat Özcan, ve Hüseyin Dere. “Trombosit sayısı Ve Ortalama Trombosit Hacminin tıkayıcı Uyku Apne Sendromu Ile ilişkisi”. The Turkish Journal of Ear Nose and Throat 25, sy. 5 (Ekim 2015): 289-94.
EndNote Atan D, Sazak Kundi FC, Özcan KM, Dere H (01 Ekim 2015) Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi. The Turkish Journal of Ear Nose and Throat 25 5 289–294.
IEEE D. Atan, F. C. Sazak Kundi, K. M. Özcan, ve H. Dere, “Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi”, Tr-ENT, c. 25, sy. 5, ss. 289–294, 2015.
ISNAD Atan, Doğan vd. “Trombosit sayısı Ve Ortalama Trombosit Hacminin tıkayıcı Uyku Apne Sendromu Ile ilişkisi”. The Turkish Journal of Ear Nose and Throat 25/5 (Ekim 2015), 289-294.
JAMA Atan D, Sazak Kundi FC, Özcan KM, Dere H. Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi. Tr-ENT. 2015;25:289–294.
MLA Atan, Doğan vd. “Trombosit sayısı Ve Ortalama Trombosit Hacminin tıkayıcı Uyku Apne Sendromu Ile ilişkisi”. The Turkish Journal of Ear Nose and Throat, c. 25, sy. 5, 2015, ss. 289-94.
Vancouver Atan D, Sazak Kundi FC, Özcan KM, Dere H. Trombosit sayısı ve ortalama trombosit hacminin tıkayıcı uyku apne sendromu ile ilişkisi. Tr-ENT. 2015;25(5):289-94.