Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in malignant and precancerous laryngeal lesions

Yıl 2017, Cilt: 27 Sayı: 3, 122 - 127, 25.07.2017

Suphi Bulğurcu İlker Burak Arslan Bünyamin Dikilitaş İbrahim Çukurova

Öz

Objectives: This study aims to investigate the relationship between neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR in patients with precancerous laryngeal lesion or laryngeal squamous cell carcinoma. Patients and Methods: This retrospective study included 98 patients 92 males, 6 females; mean age 57.4±11.3 years; range 32 to 82 years who were diagnosed to have precancerous laryngeal lesion or laryngeal squamous cell carcinoma according to histopathology result between January 2011 and June 2016. Patients were divided into two groups as those with precancerous laryngeal lesion or laryngeal squamous cell carcinoma. Results: There was a statistically significant difference between the two groups in terms of NLR and PLR values p=0.010, p=0.002, respectively . When patients with laryngeal squamous cell carcinoma were evaluated in terms of lymph node metastasis, primary localization of tumor and differentiation of tumor; there was no statistically significant difference between NLR and PLR values. However, when evaluated in terms of clinical staging, PLR value was statistically different p=0.047 while NLR value was not statistically different. Conclusion: To our knowledge, this is the first study to show that PLR can be used to differentiate precancerous laryngeal lesion and laryngeal squamous cell carcinoma.

Anahtar Kelimeler

Laryngeal, lymphocyte, neutrophil, platelet

Malign ve prekanseröz larengeal lezyonlarda nötrofil lenfosit oranı ve trombosit lenfosit oranı

Öz

Amaç: Bu çalışmada, prekanseröz larengeal lezyonu veya larengeal skuamöz hücreli karsinoması olan hastalarda nötrofil lenfosit oranı NLO ve trombosit lenfosit oranı TLO arasındaki ilişki araştırıldı.Hastalar ve Yöntemler: Bu retrospektif çalışmaya Ocak 2011 - Haziran 2016 tarihleri arasında histopatoloji sonucuna göre prekanseröz larengeal lezyon veya larengeal skuamöz hücreli karsinoma tanısı konulan 98 hasta 92 erkek, 6 kadın; ort. yaş 57.4±11.3 yıl; dağılım 32-82 yıl dahil edildi. Hastalar prekanseröz larengeal lezyonlu veya larengeal skuamöz hücreli karsinomalı olmak üzere iki gruba ayrıldı.Bulgular: İki grup arasında NLO ve TLO değerleri açısından istatistiksel olarak anlamlı farklılık vardı sırasıyla, p=0.010, p=0.002 . Larengeal skuamöz hücreli karsinomalı hastalar lenf nodu metastazı, tümörün primer yerleşimi ve tümörün diferansiasyonu açısından değerlendirildiğinde, NLO ve TLO değerleri arasında istatistiksel olarak anlamlı farklılık yoktu. Ancak klinik evrelendirme açısından değerlendirildiğinde, TLO değeri istatistiksel olarak farklı p=0.047 , NLO değeri ise istatistiksel olarak farklı değildi.Sonuç: Bildiğimiz kadarıyla, bu çalışma, TLO’nun prekanseröz larengeal lezyon ve larengeal skuamöz hücreli karsinomanın ayrımında kullanabileceğini gösteren ilk çalışmadır

Anahtar Kelimeler

Larengeal, lenfosit, nötrofil, trombosit

Kaynakça

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