Red blood cell distribution width in patients with nasal polyposis

Yıl 2017, Cilt: 27 Sayı: 5, 221 - 225, 13.11.2017

Özgül Topal Selim Sermed Erbek

Öz

Objectives: This study aims to evaluate the red blood cell distribution width RDW levels of patients with nasal polyposis NP , and investigate its value as an inflammatory parameter and possible correlation with the severity of the disease. Patients and Methods: Between January 2003 and September 2016, a total of 139 NP patients 87 males, 52 females; mean age 46.6 years; range 22 to 87 years and 80 controls 59 males, 21 females; mean age 30.3 years; range 17 to 64 years , who underwent nasal septal reconstruction surgery, were included in this retrospective controlled study. Data including polyp stage, computed tomography CT score, number of eosinophils in peripheral blood, total serum immunoglobulin E IgE and RDW were obtained from medical records. Results: Red blood cell distribution width was above normal values in 56 NP patients 40.28% . Mean RDW was 15.3906±1.41805% in NP group and 14.6413±0.83191% in the control group. The difference was statistically significant between the two groups p<0.001 . There was no statistically significant correlation between RDW and total serum IgE, number of total eosinophils in peripheral blood, polyp stage, and CT scores. Conclusion: Patients with NP showed significantly increased RDW values compared to controls. Although we failed to demonstrate an association of elevated RDW with the disease severity, this preliminary study may give rise to further prospective studies.

Anahtar Kelimeler

Inflammation, nasal polyp, red blood cell distribution width

Nazal polipli hastalarda kırmızı kan hücresi dağılım genişliği

Öz

Amaç: Bu çalışmada nazal polipli NP hastaların kırmızı kan hücresi dağılım genişliği KKDG seviyeleri değerlendirildi ve enflamatuvar bir parametre olarak önemi ve hastalık şiddeti ile muhtemel ilişkisi araştırıldı.Hastalar ve Yöntemler: Ocak 2003 - Eylül 2016 tarihleri arasında 139 NP hastası 87 erkek, 52 kadın; ort. yaş 46.6 yıl; dağılım 22-87 yıl ve nazal septal rekonstrüksiyon cerrahisi olmuş 80 kontrol hastası 59 erkek, 21 kadın; ort. yaş 30.3 yıl; dağılım 17-64 yıl bu retrospektif kontrollü çalışmaya dahil edildi. Polip evresi, bilgisayarlı tomografi BT skoru, periferik kanda eozinofil sayısı, total serum immünoglobulin E IgE ve KKDG verileri tıbbi kayıtlardan elde edildi.Bulgular: Elli altı NP’li hastada %40.28 KKDG normal değerlerin üzerindeydi. Ortalama KKDG, NP’li grupta %15.3906±1.41805, kontrol grubunda ise %14.6413±0.83191 idi. İki grup arasındaki fark istatistiksel olarak anlamlı bulundu p

Anahtar Kelimeler

Enflamasyon, nazal polip, kırmızı kan hücresi dağılım genişliği

Kaynakça

• Little SC, Early SB, Woodard CR, Shonka DC Jr, Han JK, Borish L, Steinke JW. Dual action of TGF-beta1 on nasal-polyp derived fibroblasts. Laryngoscope 2008;118:320-4.
• Damm M, Quante G, Jungehuelsing M, Stennert E. Impact of functional endoscopic sinus surgery on symptoms and quality of life in chronic rhinosinusitis. Laryngoscope 2002;112:310-5.
• Salhab M, Matai V, Salam MA. The impact of functional endoscopic sinus surgery on health status. Rhinology 2004;42:98-102.
• Drake-Lee AB. Nasal polyps. In: Kerr AG, Groves J, editors. Scott-Brown’s Otolaryngology. London: Butterworths; 1987. p. 142-53.
• Evans TC, Jehle D. The red blood cell distribution width. J Emerg Med 1991;9:71-4.
• Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-32.
• Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci 2015;52:86-105.
• Vayá A, Sarnago A, Fuster O, Alis R, Romagnoli M. Influence of inflammatory and lipidic parameters on red blood cell distribution width in a healthy population. Clin Hemorheol Microcirc 2015;59:379-85.
• Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: developing guidance for clinical trials. J Allergy Clin Immunol 2006;118:17-61.
• Lildholdt T, Rundcrantz H, Bende M, Larsen K. Glucocorticoid treatment for nasal polyps. The use of topical budesonide powder, intramuscular betamethasone, and surgical treatment. Arch Otolaryngol Head Neck Surg 1997;123:595-600.
• Lund VJ, Mackay IS. Staging in rhinosinusitus. Rhinology 1993;31:183-4.
• Stoop AE, van der Heijden HA, Biewenga J, van der Baan S. Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study. J Allergy Clin Immunol 1993;91:616-22.
• Bachert C, Wagenmann M, Hauser U, Rudack C. IL-5 synthesis is upregulated in human nasal polyp tissue. J Allergy Clin Immunol 1997;99:837-42.
• Bradley DT, Kountakis SE. Role of interleukins and transforming growth factor-beta in chronic rhinosinusitis and nasal polyposis. Laryngoscope 2005;115:684-6.
• Lackner A, Raggam RB, Stammberger H, Beham A, Braun H, Kleinhappl B, et al. The role of interleukin-16 in eosinophilic chronic rhinosinusitis. Eur Arch Otorhinolaryngol. 2007;264:887-93.
• Keseroğlu K, Banoğlu E, Kizil Y, Aydil U, Gönül II, Yilmaz M, et al. Serum interleukin-16 levels in patients with nasal polyposis. Laryngoscope 2012;122:961-4.
• Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
• Kiefer CR, Snyder LM. Oxidation and erythrocyte senescence. Curr Opin Hematol 2000;7:113-6.
• Kim DS, Shin D, Jee H, Kim TG, Kim SH, Kim DY, et al. Red blood cell distribution width is increased in patients with psoriasis vulgaris: A retrospective study on 261 patients. J Dermatol 2015;42:567-71.
• Xu WS, Qiu XM, Ou QS, Liu C, Lin JP, Chen HJ, et al. Red blood cell distribution width levels correlate with liver fibrosis and inflammation: a noninvasive serum marker panel to predict the severity of fibrosis and inflammation in patients with hepatitis B. Medicine (Baltimore) 2015;94:612.
• Özer S, Yılmaz R, Sönmezgöz E, Karaaslan E, Taşkın S, Bütün İ, et al. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Med Sci Monit 2015;21:298-303.
• Liu Q, Dang AM, Chen BW, Lv NQ, Wang X, Zheng DY. The association of red blood cell distribution width with anemia and inflammation in patients with Takayasu arteritis. Clin Chim Acta 2015;438:205-9.
• Dagli M, Eryilmaz A, Besler T, Akmansu H, Acar A, Korkmaz H. Role of free radicals and antioxidants in nasal polyps. Laryngoscope 2004;114:1200-3.
• Topal O, Kulaksızoglu S, Erbek SS. Oxidative stress and nasal polyposis: does it affect the severity of the disease? Am J Rhinol Allergy 2014;28:1-4.
• Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, et al. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood 2004;104:2565-73.
• Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women's Health and Aging Study I. Clin Nutr 2010;29:600-4.
• Zou XL, Lin XJ, Ni X, Wang J, Liu W, Wei J. Baseline Red Blood Cell Distribution Width Correlates with Disease Activity and Therapeutic Outcomes in Patients with Systemic Lupus Erythematosus, Irrespective of Anemia Status. Clin Lab 2016;62:1841-50.