Oral cavity cancers: A single-center study

Yıl 2019, Cilt: 29 Sayı: 1, 34 - 41, 10.03.2019

Göksel Turhal Fetih Furkan Şahin İsa Kaya Kerem Öztürk Nurullah Serdar Akyıldız Ümit Uluöz

Öz

Objectives: This study aims to evaluate demographic characteristics, tumor characteristics, and survival outcomes of surgically treated patients with oral cavity cancer OCC . Patients and Methods: A total of 459 OCC patients 269 males, 190 females; mean age 61.4±15.0 years; range, 18 to 90 years who were treated with surgery between January 2000 and December 2015 were retrospectively analyzed. Demographic data, diagnosis, histopathological type, tumor origin, tumor stage, neck status, type of surgery, reconstruction technique, complications, follow-up duration, recurrence, and survival status were recorded. Results: The tumor originated from the lip in 134 29.2% of the patients. The histopathological diagnosis was a squamous cell carcinoma in 403 patients 87.8% . The five-year overall survival and disease-free survival rates were 69.5% and 60.8%, respectively. The five-year overall survival rate was significantly lower in patients with neck metastasis p<0.05 . Conclusion: Our study results suggest that regional lymph node metastasis, age, and surgical margin are the main factors affecting survival and prognosis in OCC.

Anahtar Kelimeler

Oral cavity cancer, oral cavity tumor, Survival

Kaynakça

• Available from: http://gco.iarc.fr/today/fact-sheets- populations.
• Warnakulasuriya S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol 2010;46:407-10.
• Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people--a comprehensive literature review. Oral Oncol 2001;37:401-18.
• Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer 2005;103:1843-9.
• Deschler DG, Erman AB. Oral cavity cancer. In: Johnson JT and Rosen CA, editors. Bailey’s Head and Neck Surgery-Otolaryngology. 5th ed. Baltimore: Lippincott Baltimore Williams & Wilkins; 2014. p. 1849-74.
• Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am 2015;24:491-508.
• Daley T, Darling M. Nonsquamous cell malignant tumours of the oral cavity: an overview. J Can Dent Assoc 2003;69:577-82.
• Alataş N, Akyol U, Sungur A. Dilde epidermoid kanserlerde yaş, cinsiyet, sigara ve alkol kullanımının prognoza etkileri. K.B.B. ve Baş Boyun Cerrahisi Dergisi 2000;8:46-50.
• Mansour OI, Snyderman CH, D’Amico F. Association between tobacco use and metastatic neck disease. Laryngoscope 2003;113:161-6.
• Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010;17:1471-4.
• Olaleye O, Ekrikpo U, Lyne O, Wiseberg J. Incidence and survival trends of lip, intra-oral cavity and tongue base cancers in south-east England. Ann R Coll Surg Engl 2015;97:229-34.
• Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
• Majchrzak E, Szybiak B, Wegner A, Pienkowski P, Pazdrowski J, Luczewski L, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol Oncol 2014;48:1-10.
• Boyle P, Macfarlane GJ, Maisonneuve P, Zheng T, Scully C, Tedesco B. Epidemiology of mouth cancer in 1989: a review. J R Soc Med 1990;83:724-30.
• van Dijk BA, Brands MT, Geurts SM, Merkx MA, Roodenburg JL. Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands. Int J Cancer 2016;139:574-83.
• Kruse AL, Bredell M, Grätz KW. Oral cancer in men and women: are there differences? Oral Maxillofac Surg 2011;15:51-5.
• Schwam ZG, Sosa JA, Roman S, Judson BL. Complications and mortality following surgery for oral cavity cancer: analysis of 408 cases. Laryngoscope 2015;125:1869-73.
• Kenborg L, Jİrgensen AD, Budtz-Jİrgensen E, Knudsen LE, Hansen J. Occupational exposure to the sun and risk of skin and lip cancer among male wage earners in Denmark: a population-based case-control study. Cancer Causes Control 2010;21:1347-55.
• Falaki F, Dalirsani Z, Pakfetrat A, Falaki A, Saghravanian N, Nosratzehi T, et al. Clinical and histopathological analysis of oral squamous cell carcinoma of young patients in Mashhad, Iran: a retrospective study and review of literature. Med Oral Patol Oral Cir Bucal 2011;16:473-7.
• Warnakulasuriya S, Mak V, Möller H. Oral cancer survival in young people in South East England. Oral Oncol 2007;43:982-6.
• Lassig AA, Lindgren BR, Fernandes P, Cooper S, Ardeshipour F, Schotzko C, et al. The effect of young age on outcomes in head and neck cancer. Laryngoscope 2013;123:1896-902.
• Blanchard P, Belkhir F, Temam S, El Khoury C, De Felice F, Casiraghi O, et al. Outcomes and prognostic factors for squamous cell carcinoma of the oral tongue in young adults: a single-institution case-matched analysis. Eur Arch Otorhinolaryngol 2017;274:1683-90.
• Sutton DN, Brown JS, Rogers SN, Vaughan ED, Woolgar JA. The prognostic implications of the surgical margin in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 2003;32:30-4.
• Kurita H, Nakanishi Y, Nishizawa R, Xiao T, Kamata T, Koike T, et al. Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma. Oral Oncol 2010;46:814-7.
• Kurita H, Nakanishi Y, Nishizawa R, Xiao T, Kamata T, Koike T, et al. Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma. Oral Oncol 2010;46:814-7.
• Tasche KK, Buchakjian MR, Pagedar NA, Sperry SM. Definition of “Close Margin” in Oral Cancer Surgery and Association of Margin Distance With Local Recurrence Rate. JAMA Otolaryngol Head Neck Surg 2017;143:1166-1172.
• Auluck A, Hislop G, Bajdik C, Hay J, Bottorff JL, Zhang L, et al. Gender- and ethnicity-specific survival trends of oral cavity and oropharyngeal cancers in British Columbia. Cancer Causes Control 2012;23:1899-909.
• Grandis JR, Snyderman CH, Johnson JT, Yu VL, D’Amico F. Postoperative wound infection. A poor prognostic sign for patients with head and neck cancer. Cancer 1992;70:2166-70.
• Yao CM, Ziai H, Tsang G, Copeland A, Brown D, Irish JC, et al. Surgical site infections following oral cavity cancer resection and reconstruction is a risk factor for plate exposure. J Otolaryngol Head Neck Surg 2017;46:30.
• Cheng SJ, Lee JJ, Cheng SL, Chen HM, Chang HH, Wang YP, et al. Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma. Oral Oncol 2012;48:424-8.
• Masuda M, Ruan HY, Ito A, Nakashima T, Toh S, Wakasaki T, et al. Signal transducers and activators of transcription 3 up-regulates vascular endothelial growth factor production and tumor angiogenesis in head and neck squamous cell carcinoma. Oral Oncol 2007;43:785-90.
• Kim SM. Human papilloma virus in oral cancer. J Korean Assoc Oral Maxillofac Surg 2016;42:327-36.
• Simonato LE, Garcia JF, Sundefeld ML, Mattar NJ, Veronese LA, Miyahara GI. Detection of HPV in mouth floor squamous cell carcinoma and its correlation with clinicopathologic variables, risk factors and survival. J Oral Pathol Med 2008;37:593-8.