Objectives: This study aims to evaluate facial complications of dermal fillers and to increase the public awareness about serious adverse outcomes of these applications. Patients and Methods: Between January 2015 and June 2019, a total of 12 patients 2 males, 10 females; mean age 41 years; range, 28 to 64 years who experienced hyaluronic acid HA filler-related complications were retrospectively analyzed. Complications were recorded using the hospital records. Results: The mean follow-up was 7 range, 6 to 9 months. In one patient, livedo reticularis over the nose caused by the filler to the nasolabial fold was seen. In another patient, livedo reticularis over the nose caused by the HA filler for tip augmentation was observed. Both patients were treated with heating and oral acetylsalicylic acid. In another two patients, cellulitic infections were observed. Oral antibiotics and topical antibiotic cream were applied. In two patients, infraorbital edema was seen caused by HA filler application to the nasojugal folds. Hyaluronidase was applied for treatment. In two patients, a granuloma was seen at the right infraorbital region and at the left nasolabial region, respectively. Both of them were treated with hyaluronidase. In one patient, a granuloma and infectious abscess of the upper lip caused by the HA filler application for lip augmentation was observed. For the treatment of the abscess, surgical drainage was used and hyaluronidase was applied for the treatment of the granuloma. In three patients, bruising was observed which was treated with the Arnica cream. Conclusion: Our study results show that fillers are not completely innocent products. We recommend that these materials should be used in experienced hands in accordance with the relevant regulations.
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of Injectables-Dermal Fillers. J Cutan Aesthet Surg
2018;11:60-6.
2. Rzany B, DeLorenzi C. Understanding, Avoiding, and
Managing Severe Filler Complications. Plast Reconstr
Surg 2015;136:196-203.
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part 2: vascular complications. Aesthet Surg J
2014;34:584-600.
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Gerber PA. Hyaluronidase: from clinical applications
to molecular and cellular mechanisms. Eur J Med Res
2016;21:5.
5. Carruthers JD, Fagien S, Rohrich RJ, Weinkle S,
Carruthers A. Blindness caused by cosmetic filler
injection: a review of cause and therapy. Plast Reconstr
Surg 2014;134:1197-201.
6. Hexsel D, Soirefmann M, Porto MD, Siega C, SchillingSouza J, Brum C. Double-blind, randomized, controlled
clinical trial to compare safety and efficacy of a
metallic cannula with that of a standard needle for soft
tissue augmentation of the nasolabial folds. Dermatol
Surg 2012;38:207-14.
7. Signorini M, Liew S, Sundaram H, De Boulle KL,
Goodman GJ, Monheit G, et al. Global Aesthetics
Consensus: Avoidance and Management of
Complications from Hyaluronic Acid FillersEvidence- and Opinion-Based Review and Consensus
Recommendations. Plast Reconstr Surg 2016;137:961-71.
1. Vedamurthy M. Beware What You Inject: Complications
of Injectables-Dermal Fillers. J Cutan Aesthet Surg
2018;11:60-6.
2. Rzany B, DeLorenzi C. Understanding, Avoiding, and
Managing Severe Filler Complications. Plast Reconstr
Surg 2015;136:196-203.
3. DeLorenzi C. Complications of injectable fillers,
part 2: vascular complications. Aesthet Surg J
2014;34:584-600.
4. Buhren BA, Schrumpf H, Hoff NP, Bölke E, Hilton S,
Gerber PA. Hyaluronidase: from clinical applications
to molecular and cellular mechanisms. Eur J Med Res
2016;21:5.
5. Carruthers JD, Fagien S, Rohrich RJ, Weinkle S,
Carruthers A. Blindness caused by cosmetic filler
injection: a review of cause and therapy. Plast Reconstr
Surg 2014;134:1197-201.
6. Hexsel D, Soirefmann M, Porto MD, Siega C, SchillingSouza J, Brum C. Double-blind, randomized, controlled
clinical trial to compare safety and efficacy of a
metallic cannula with that of a standard needle for soft
tissue augmentation of the nasolabial folds. Dermatol
Surg 2012;38:207-14.
7. Signorini M, Liew S, Sundaram H, De Boulle KL,
Goodman GJ, Monheit G, et al. Global Aesthetics
Consensus: Avoidance and Management of
Complications from Hyaluronic Acid FillersEvidence- and Opinion-Based Review and Consensus
Recommendations. Plast Reconstr Surg 2016;137:961-71.
Özkan, A. Ç., & Çelet Özden, B. (2019). Evaluation of facial complications of hyaluronic acid fillers. The Turkish Journal of Ear Nose and Throat, 29(3), 134-141.
AMA
Özkan AÇ, Çelet Özden B. Evaluation of facial complications of hyaluronic acid fillers. Tr-ENT. Eylül 2019;29(3):134-141.
Chicago
Özkan, Aret Çerçi, ve Burcu Çelet Özden. “Evaluation of Facial Complications of Hyaluronic Acid Fillers”. The Turkish Journal of Ear Nose and Throat 29, sy. 3 (Eylül 2019): 134-41.
EndNote
Özkan AÇ, Çelet Özden B (01 Eylül 2019) Evaluation of facial complications of hyaluronic acid fillers. The Turkish Journal of Ear Nose and Throat 29 3 134–141.
IEEE
A. Ç. Özkan ve B. Çelet Özden, “Evaluation of facial complications of hyaluronic acid fillers”, Tr-ENT, c. 29, sy. 3, ss. 134–141, 2019.
ISNAD
Özkan, Aret Çerçi - Çelet Özden, Burcu. “Evaluation of Facial Complications of Hyaluronic Acid Fillers”. The Turkish Journal of Ear Nose and Throat 29/3 (Eylül 2019), 134-141.
JAMA
Özkan AÇ, Çelet Özden B. Evaluation of facial complications of hyaluronic acid fillers. Tr-ENT. 2019;29:134–141.
MLA
Özkan, Aret Çerçi ve Burcu Çelet Özden. “Evaluation of Facial Complications of Hyaluronic Acid Fillers”. The Turkish Journal of Ear Nose and Throat, c. 29, sy. 3, 2019, ss. 134-41.
Vancouver
Özkan AÇ, Çelet Özden B. Evaluation of facial complications of hyaluronic acid fillers. Tr-ENT. 2019;29(3):134-41.