Evaluation of neutrophil-to-lymphocyte ratio in patients with symptomatic rhinitis

Yıl 2019, Cilt: 29 Sayı: 4, 172 - 177, 10.12.2019

Engin Başer Papatya Bayrak Değirmenci İlker Burak Arslan İbrahim Çukurova

Öz

Objectives: In this study, we aimed to measure the diagnostic value of neutrophil-to-lymphocyte ratio NLR in both perennial allergic rhinitis AR and non-allergic rhinitis NAR patients during their period of active symptoms. Patients and Methods: A total of 161 patients 101 males, 60 females; mean age 34.0±11.1 years; range, 18 to 56 years consisting of 70 persistent allergic rhinitis PAR and 39 NAR patients diagnosed between March 2018 and March 2019 in the adult allergy outpatient clinic, having a Total Nasal Symptom Score TNSS of ≥8, and recent complete blood count results available before undergoing any medical treatment and 52 control patients 28 males, 24 females; mean age 31.7±7.8 years; range, 18 to 44 years . The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Results: There was no statistically significant difference in the age or gender between the groups p>0.05 . There was no statistically significant difference in the neutrophil, lymphocyte, and NLR between the groups p>0.05 . Conclusion: Our study shows that NLR is not a useful tool in the diagnosis and management of treatment in PAR and NAR in adults

Anahtar Kelimeler

Allergic rhinitis, inflammation, neutrophil-to-lymphocyte ratio, non-allergic rhinitis

Kaynakça

• Dogru M, Evcimik MF, Cirik AA. Is neutrophil- lymphocyte ratio associated with the severity of allergic rhinitis in children? Eur Arch Otorhinolaryngol 2016;273:3175-8.
• Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63:8-160.
• Lund VJ, Stammberger H, Fokkens WJ, Beale T, Bernal- Sprekelsen M, Eloy P, et al. European position paper on the anatomical terminology of the internal nose and paranasal sinuses. Rhinol Suppl 2014;24:1-34.
• Greiner AN, Hellings PW, Rotiroti G, Scadding GK. Allergic rhinitis. Lancet 2011;378:2112-22.
• Hellings PW, Fokkens WJ, Akdis C, Bachert C, Cingi C, Dietz de Loos D, et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy 2013;68:1-7.
• Yıldırım YS, Apuhan T, Koçoğlu E, Simşek T, Kazaz H. High sensitivity C-reactive protein levels in chronic rhinosinusitis and allergic rhinitis. Kulak Burun Bogaz Ihtis Derg 2011;21:266-9.
• Atan D, Özcan KM, Köseoğlu S, İkincioğulları A, Çetin MA, Ensari S, et al. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. [Article in Turkish] Kulak Burun Bogaz Ihtis Derg 2015;25:97-101.
• Dogru M, Yesiltepe Mutlu RG. The evaluation of neutrophil-lymphocyte ratio in children with asthma. Allergol Immunopathol 2016;44:292-6.
• Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012;5:2.
• Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, Horgan PG, Clarke SJ. A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer 2012;107:695-9.
• Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9.
• Yücel Ekici N. Is there any correlation between allergy and hematological parameters in children with allergic rhinitis? Kocaeli Med J. 2019;8:29-34.
• Hermelingmeier KE, Weber RK, Hellmich M, Heubach CP, Mösges R. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy 2012;26:e119-25.
• Sansila K, Eiamprapai P, Sawangjit R. Effects of self- prepared hypertonic nasal saline irrigation in allergic rhinitis: A randomized controlled trial. Asian Pac J Allergy Immunol 2018. [Epub ahead of print]
• Cingi C, Kayabasoglu G, Nacar A. Update on the medical treatment of allergic rhinitis. Inflamm Allergy Drug Targets 2009;8:96-103.
• Boulay ME, Boulet LP. The Rhinitis control scoring system: Development and validation. Am J Rhinol Allergy 2016;30:54-9.
• Meltzer EO. Evaluating rhinitis: clinical, rhinomanometric, and cytologic assessments. J Allergy Clin Immunol 1988;82:900-8.
• Dreborg S, Frew A. Position Paper: Allergen standardization and skin tests. Allergy 1993;48:49-54.
• Tran NP, Vickery J, Blaiss MS. Management of rhinitis: allergic and non-allergic. Allergy Asthma Immunol Res 2011;3:148-56.
• Aydoğdu İ. Nazal polipozis hastalarında nötrofil/ lenfosit oranı ve eozinofil/lenfosit oranının prognostik değeri. Prax Otorhinolaryngol 2019;6:92-95.
• Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C, et al. Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas 2006;32:22-8.
• Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5-14.
• de Jager CP, Wever PC, Gemen EF, Kusters R, van Gageldonk-Lafeber AB, van der Poll T, et al. The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PLoS One 2012;7:e46561.
• Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F, et al. Neutrophil-to-lymphocyte ratio as a novel- potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-81.
• Aydoğdu İ, Yıldırım G, Kumral TL, Saltürk Z, Aydoğdu Z, İnan M, et al. New prognostic parameters of sudden hearing loss: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Med J Okmeydani Train Res Hosp 2017;33:1-5.
• Kahramanca S, Ozgehan G, Seker D, Gökce EI, Seker G, Tunç G, et al. Neutrophil-to-lymphocyte ratio as a predictor of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2014;20:19-22.
• Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34:1400-4.
• Göker AE, Ekincioglu E, Alagöz MH, Hummatov R, Arkan ME, Baskadem Yilmazer A, et al. The association of allergic rhinitis severity with neutrophil-lymphocyte and platelet-lymphocyte ratio in adults. Eur Arch Otorhinolaryngol 2019;276:3383-8.
• Kiliçkaya MM, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. Int J Otolaryngol 2015;2015:981950.
• Ozturk C, Balta S, Balta I, Demirkol S, Celik T, Turker T, et al. Neutrophil-lymphocyte ratio and carotid- intima media thickness in patients with Behçet disease without cardiovascular involvement. Angiology 2015;66:291-6.
• Gelardi M, Incorvaia C, Fiorella ML, Petrone P, Quaranta N, Russo C, et al. The clinical stage of allergic rhinitis is correlated to inflammation as detected by nasal cytology. Inflamm Allergy Drug Targets 2011;10:472-6.