BibTex RIS Kaynak Göster

Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?

Yıl 2020, Cilt: 30 Sayı: 2, 52 - 57, 09.07.2020

Üstün Osma Ömer Tarık Selçuk Mete Eyigör Levent Renda Nursel Türkoğlu Selçuk Hülya Eyigör Mustafa Deniz Yılmaz Oğuzhan İlden Ünal Gökalp Işık Hande Konsuk Ünlü Meral Gültekin

Öz

Objectives: The aim of this study was to evaluate serum copeptin levels in patients with obstructive sleep apnea OSA before and after the positive airway pressure PAP treatment. Patients and Methods: A total of 16 patients 14 males, 2 females; median age 48 years; range, 38 to 60 years with severe sleep apnea based on the Apnea Hypopnea Index AHI >30 and 20 healthy controls 10 males, 10 females; median age 35.5 years; range, 22 to 47 years were included in this study between October 2014 and December 2015. Full-night polysomnography was applied to each patient. Serum copeptin levels were determined using the enzyme-linked immunosorbent assay in both groups. Serum copeptin level measurement was repeated in the patient group after one year of PAP treatment. Results: After one year of PAP treatment, serum copeptin levels of the patients with OSA decreased, although there was no statistically significant difference before and after treatment. Conclusion: Increased serum copeptin concentration may reflect a response to moderate stress in many diseases, particularly cardiovascular diseases. Based on our study results, there was no significant difference between the severe OSA group and healthy volunteers and before and after treatment among the patients with severe OSA.

Anahtar Kelimeler

Copeptin severe obstructive sleep apnea sleep apnea vasopressin.

Kaynakça

  • Dyken ME, Im KB. Obstructive sleep apnea and stroke. Chest 2009;136:1668-77.
  • Tuomilehto H, Seppä J, Uusitupa M. Obesity and obstructive sleep apnea--clinical significance of weight loss Sleep Med Rev 2013;17:321-9.
  • Quercioli A, Mach F, Montecucco F. Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS). Sleep Breath 2010;14:261-9.
  • Ozben S, Guvenc TS, Huseyinoglu N, Sanivar HS, Hanikoglu F, Cort A, et al. Low serum copeptin levels in patients with obstructive sleep apnea. Sleep Breath 2013;17:1187-92.
  • Yalta K, Yalta T, Sivri N, Yetkin E. Copeptin and cardiovascular disease: a review of a novel neurohormone. Int J Cardiol 2013;167:1750-9.
  • Katan M, Morgenthaler N, Widmer I, Puder JJ, König C, Müller B, et al. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Endocrinol Lett 2008;29:341-6.
  • Selcuk OT, Eyigor M, Renda L, Osma U, Eyigor H, Selcuk NT, et al. Can we use serum copeptin levels as a biomarker in obstructive sleep apnea syndrome? J Craniomaxillofac Surg 2015;43:879-82.
  • Çınarka H, Kayhan S, Karataş M, Yavuz A, Gümüş A, Özyurt S, et al. Copeptin: a new predictor for severe obstructive sleep apnea. Ther Clin Risk Manag 2015;11:589-94.
  • Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep Breath 2008;12:161-8.
  • Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597-619.
  • Kiely JL, McNicholas WT. Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. Eur Respir J 2000;16:128-33.
  • Yalta K, Sıvrı N, Yalta T, Geyik B, Aksoy Y, Yetkın E. Copeptin (C-terminal provasopressin): a promising marker of arrhythmogenesis in arrhythmia prone subjects? Int J Cardiol 2011;148:105.
  • Seligman R, Ramos-Lima LF, Oliveira Vdo A, Sanvicente C, Pacheco EF, Dalla Rosa K. Biomarkers in community-acquired pneumonia: a state-of-the-art review. Clinics (Sao Paulo) 2012;67:1321-5.
  • Itoi K, Jiang YQ, Iwasaki Y, Watson SJ. Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol 2004;16:348-55.
  • Voors AA, von Haehling S, Anker SD, Hillege HL, Struck J, Hartmann O, et al. C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. Eur Heart J 2009;30:1187-94.
  • Katan M, Müller B, Christ-Crain M. Copeptin: a new and promising diagnostic and prognostic marker. Crit Care 2008;12:117.
  • Christ-Crain M, Müller B. Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J 2007;30:556-73.

Yıl 2020, Cilt: 30 Sayı: 2, 52 - 57, 09.07.2020

Üstün Osma Ömer Tarık Selçuk Mete Eyigör Levent Renda Nursel Türkoğlu Selçuk Hülya Eyigör Mustafa Deniz Yılmaz Oğuzhan İlden Ünal Gökalp Işık Hande Konsuk Ünlü Meral Gültekin

Öz

Kaynakça

  • Dyken ME, Im KB. Obstructive sleep apnea and stroke. Chest 2009;136:1668-77.
  • Tuomilehto H, Seppä J, Uusitupa M. Obesity and obstructive sleep apnea--clinical significance of weight loss Sleep Med Rev 2013;17:321-9.
  • Quercioli A, Mach F, Montecucco F. Inflammation accelerates atherosclerotic processes in obstructive sleep apnea syndrome (OSAS). Sleep Breath 2010;14:261-9.
  • Ozben S, Guvenc TS, Huseyinoglu N, Sanivar HS, Hanikoglu F, Cort A, et al. Low serum copeptin levels in patients with obstructive sleep apnea. Sleep Breath 2013;17:1187-92.
  • Yalta K, Yalta T, Sivri N, Yetkin E. Copeptin and cardiovascular disease: a review of a novel neurohormone. Int J Cardiol 2013;167:1750-9.
  • Katan M, Morgenthaler N, Widmer I, Puder JJ, König C, Müller B, et al. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Endocrinol Lett 2008;29:341-6.
  • Selcuk OT, Eyigor M, Renda L, Osma U, Eyigor H, Selcuk NT, et al. Can we use serum copeptin levels as a biomarker in obstructive sleep apnea syndrome? J Craniomaxillofac Surg 2015;43:879-82.
  • Çınarka H, Kayhan S, Karataş M, Yavuz A, Gümüş A, Özyurt S, et al. Copeptin: a new predictor for severe obstructive sleep apnea. Ther Clin Risk Manag 2015;11:589-94.
  • Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep Breath 2008;12:161-8.
  • Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 2012;8:597-619.
  • Kiely JL, McNicholas WT. Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. Eur Respir J 2000;16:128-33.
  • Yalta K, Sıvrı N, Yalta T, Geyik B, Aksoy Y, Yetkın E. Copeptin (C-terminal provasopressin): a promising marker of arrhythmogenesis in arrhythmia prone subjects? Int J Cardiol 2011;148:105.
  • Seligman R, Ramos-Lima LF, Oliveira Vdo A, Sanvicente C, Pacheco EF, Dalla Rosa K. Biomarkers in community-acquired pneumonia: a state-of-the-art review. Clinics (Sao Paulo) 2012;67:1321-5.
  • Itoi K, Jiang YQ, Iwasaki Y, Watson SJ. Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol 2004;16:348-55.
  • Voors AA, von Haehling S, Anker SD, Hillege HL, Struck J, Hartmann O, et al. C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. Eur Heart J 2009;30:1187-94.
  • Katan M, Müller B, Christ-Crain M. Copeptin: a new and promising diagnostic and prognostic marker. Crit Care 2008;12:117.
  • Christ-Crain M, Müller B. Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J 2007;30:556-73.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Üstün Osma Bu kişi benim

Ömer Tarık Selçuk Bu kişi benim

Mete Eyigör Bu kişi benim

Levent Renda Bu kişi benim

Nursel Türkoğlu Selçuk Bu kişi benim

Hülya Eyigör Bu kişi benim

Mustafa Deniz Yılmaz Bu kişi benim

Oğuzhan İlden Bu kişi benim

Ünal Gökalp Işık Bu kişi benim

Hande Konsuk Ünlü Bu kişi benim

Meral Gültekin Bu kişi benim

Yayımlanma Tarihi 9 Temmuz 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 30 Sayı: 2

Kaynak Göster

APA Osma, Ü., Selçuk, Ö. T., Eyigör, M., Renda, L., vd. (2020). Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. The Turkish Journal of Ear Nose and Throat, 30(2), 52-57.
AMA Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. Temmuz 2020;30(2):52-57.
Chicago Osma, Üstün, Ömer Tarık Selçuk, Mete Eyigör, Levent Renda, Nursel Türkoğlu Selçuk, Hülya Eyigör, Mustafa Deniz Yılmaz, Oğuzhan İlden, Ünal Gökalp Işık, Hande Konsuk Ünlü, ve Meral Gültekin. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat 30, sy. 2 (Temmuz 2020): 52-57.
EndNote Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M (01 Temmuz 2020) Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. The Turkish Journal of Ear Nose and Throat 30 2 52–57.
IEEE Ü. Osma, “Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?”, Tr-ENT, c. 30, sy. 2, ss. 52–57, 2020.
ISNAD Osma, Üstün vd. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat 30/2 (Temmuz 2020), 52-57.
JAMA Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. 2020;30:52–57.
MLA Osma, Üstün vd. “Do Serum Copeptin Levels Change With Positive Airway Pressure Treatment in Patients With Severe Obstructive Sleep Apnea?”. The Turkish Journal of Ear Nose and Throat, c. 30, sy. 2, 2020, ss. 52-57.
Vancouver Osma Ü, Selçuk ÖT, Eyigör M, Renda L, Türkoğlu Selçuk N, Eyigör H, Yılmaz MD, İlden O, Işık ÜG, Konsuk Ünlü H, Gültekin M. Do serum copeptin levels change with positive airway pressure treatment in patients with severe obstructive sleep apnea?. Tr-ENT. 2020;30(2):52-7.