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The effect of vitamin D levels on prognosis of patients with facial paralysis

Yıl 2020, Cilt: 30 Sayı: 4, 118 - 122, 15.12.2020

Öz

Objectives: This study aims to investigate the serum 25-hydroxyvitamin D3 [25 OH D3] levels of patients with Bell’s palsy BP , and to evaluate their role in prognosis and their impact on the disease etiology. Patients and Methods: A total of 49 patients 30 males, 19 females; mean age: 42.2±13.6 years; range, 19 to 67 years who were diagnosed with BP and treated at our clinic between October 2019 and April 2020 were included. Blood samples were collected within 24 h after the onset of BP symptoms, and a standard oral pharmacological treatment was administered with prednisolone 1 mg/kg for 10 days and acyclovir 700 mg/day for six days. All patients were graded according to the House-Brackmann scale HBS . The patients were divided into three groups as Grade 2, Grade 3, Grade ≥4. The patients with BP were further divided into two groups as healed n=36 and not-healed ones n=13 . The vitamin D levels of the groups were compared. Results: Eleven 22% patients were in the Grade 2 group, 21 43% patients were in the Grade 3 group, and 17 35% patients were in the Grade ≥4 group. A significant decrease in vitamin D levels was observed in the patients with HBS Grade ≥4, compared to Grade 3 and Grade 2 groups p=0.002 and p<0.001, respectively . Vitamin D levels were significantly higher among the patients without sequelae than those with sequelae p<0.001 . Conclusion: Our study results indicate that vitamin D deficiency can affect prognosis of BP patients.

Kaynakça

  • Adour KK. Current concepts in neurology: Diagnosis and management of facial paralysis. N Engl J Med 1982;307:348-51.
  • Fisch U. Management of intratemporal facial nerve injuries. J Laryngol Otol 1980;94:129-34.
  • Murthy JM, Saxena AB. Bell's palsy: Treatment guidelines. Ann Indian Acad Neurol 2011;14(Suppl 1):S70-2.
  • Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, et al. Clinical practice guideline: Bell’s palsy. Otolaryngol Head Neck Surg 2013;149(3 Suppl):S1-27.
  • Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piątkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep 2013;65:271-8.
  • Holick MF. Vitamin D for health and in chronic kidney disease. Semin Dial 2005;18:266-75.
  • Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
  • Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005;29:21-30.
  • Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998;78:1193-231.
  • Vanherwegen AS, Gysemans C, Mathieu C. Regulation of immune function by vitamin D and its use in diseases of immunity. Endocrinol Metab Clin North Am 2017;46:1061-94.
  • Laird E, McNulty H, Ward M, Hoey L, McSorley E, Wallace JM, et al. Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab 2014;99:1807-15.
  • Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annu Rev Pharmacol Toxicol 2001;41:421-42.
  • Cornet A, Baudet C, Neveu I, Baron-Van Evercooren A, Brachet P, Naveilhan P. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res 1998;53:742-6.
  • Baas D, Prüfer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarliève LL, et al. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 2000;31:59-68.
  • Holick MF. Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73-8.
  • Alberton DL, Zed PJ. Bell’s palsy: A review of treatment using antiviral agents. Ann Pharmacother 2006;40:1838-42.
  • Tiemstra JD, Khatkhate N. Bell's palsy: Diagnosis and management. Am Fam Physician 2007;76:997-1002.
  • Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front Physiol 2014;5:151.
  • Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000;374:334-8.
  • Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J, et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 2006;36:361-70.
  • Kim TH, Lee B, Kwon E, Choi SJ, Lee YH, Song GG, et al. Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/ macrophages. Immunol Lett 2013;154:80-5.
  • Abou-Raya S, Helmii M, Abou-Raya A. Bone and mineral metabolism in older adults with Parkinson's disease. Age Ageing 2009;38:675-80.
  • Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, et al. Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury. PLoS One 2013;8:e65034.
  • Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl 2002;(549):4-30.
  • Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Gágyor I. The diagnosis and treatment of idiopathic facial paresis (Bell’s palsy). Dtsch Arztebl Int 2019;116:692-702.
  • Barlow PG, Svoboda P, Mackellar A, Nash AA, York IA, Pohl J, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One 2011;6:e25333.
  • Zhao Y, Ran Z, Jiang Q, Hu N, Yu B, Zhu L, et al. Vitamin D alleviates rotavirus infection through a Microrna-155-5p mediated regulation of the TBK1/ IRF3 signaling pathway in vivo and in vitro. Int J Mol Sci 2019;20:3562.
  • Şenkal E, Ünüvar E, Seren L, Göl C, Durankuş F. D vitamini bakılmasının gerekliliği ve düzeylerinin yorumu. Çocuk Dergisi 2018;18:97-102.
Yıl 2020, Cilt: 30 Sayı: 4, 118 - 122, 15.12.2020

Öz

Kaynakça

  • Adour KK. Current concepts in neurology: Diagnosis and management of facial paralysis. N Engl J Med 1982;307:348-51.
  • Fisch U. Management of intratemporal facial nerve injuries. J Laryngol Otol 1980;94:129-34.
  • Murthy JM, Saxena AB. Bell's palsy: Treatment guidelines. Ann Indian Acad Neurol 2011;14(Suppl 1):S70-2.
  • Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, et al. Clinical practice guideline: Bell’s palsy. Otolaryngol Head Neck Surg 2013;149(3 Suppl):S1-27.
  • Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piątkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep 2013;65:271-8.
  • Holick MF. Vitamin D for health and in chronic kidney disease. Semin Dial 2005;18:266-75.
  • Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
  • Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005;29:21-30.
  • Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998;78:1193-231.
  • Vanherwegen AS, Gysemans C, Mathieu C. Regulation of immune function by vitamin D and its use in diseases of immunity. Endocrinol Metab Clin North Am 2017;46:1061-94.
  • Laird E, McNulty H, Ward M, Hoey L, McSorley E, Wallace JM, et al. Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab 2014;99:1807-15.
  • Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annu Rev Pharmacol Toxicol 2001;41:421-42.
  • Cornet A, Baudet C, Neveu I, Baron-Van Evercooren A, Brachet P, Naveilhan P. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res 1998;53:742-6.
  • Baas D, Prüfer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarliève LL, et al. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 2000;31:59-68.
  • Holick MF. Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73-8.
  • Alberton DL, Zed PJ. Bell’s palsy: A review of treatment using antiviral agents. Ann Pharmacother 2006;40:1838-42.
  • Tiemstra JD, Khatkhate N. Bell's palsy: Diagnosis and management. Am Fam Physician 2007;76:997-1002.
  • Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front Physiol 2014;5:151.
  • Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000;374:334-8.
  • Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J, et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 2006;36:361-70.
  • Kim TH, Lee B, Kwon E, Choi SJ, Lee YH, Song GG, et al. Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/ macrophages. Immunol Lett 2013;154:80-5.
  • Abou-Raya S, Helmii M, Abou-Raya A. Bone and mineral metabolism in older adults with Parkinson's disease. Age Ageing 2009;38:675-80.
  • Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, et al. Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury. PLoS One 2013;8:e65034.
  • Peitersen E. Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl 2002;(549):4-30.
  • Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Gágyor I. The diagnosis and treatment of idiopathic facial paresis (Bell’s palsy). Dtsch Arztebl Int 2019;116:692-702.
  • Barlow PG, Svoboda P, Mackellar A, Nash AA, York IA, Pohl J, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One 2011;6:e25333.
  • Zhao Y, Ran Z, Jiang Q, Hu N, Yu B, Zhu L, et al. Vitamin D alleviates rotavirus infection through a Microrna-155-5p mediated regulation of the TBK1/ IRF3 signaling pathway in vivo and in vitro. Int J Mol Sci 2019;20:3562.
  • Şenkal E, Ünüvar E, Seren L, Göl C, Durankuş F. D vitamini bakılmasının gerekliliği ve düzeylerinin yorumu. Çocuk Dergisi 2018;18:97-102.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Ayşe Enise Göker Bu kişi benim

Semih Karaketir Bu kişi benim

Maide Hacer Alagöz Bu kişi benim

Ayca Başkadem Yılmazer Bu kişi benim

Hüseyin Sarı Bu kişi benim

Hasan Sami Bircan Bu kişi benim

Nilgün Başaran Bu kişi benim

Yayımlanma Tarihi 15 Aralık 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 30 Sayı: 4

Kaynak Göster

APA Göker, A. E., Karaketir, S., Alagöz, M. H., Başkadem Yılmazer, A., vd. (2020). The effect of vitamin D levels on prognosis of patients with facial paralysis. The Turkish Journal of Ear Nose and Throat, 30(4), 118-122.
AMA Göker AE, Karaketir S, Alagöz MH, Başkadem Yılmazer A, Sarı H, Bircan HS, Başaran N. The effect of vitamin D levels on prognosis of patients with facial paralysis. Tr-ENT. Aralık 2020;30(4):118-122.
Chicago Göker, Ayşe Enise, Semih Karaketir, Maide Hacer Alagöz, Ayca Başkadem Yılmazer, Hüseyin Sarı, Hasan Sami Bircan, ve Nilgün Başaran. “The Effect of Vitamin D Levels on Prognosis of Patients With Facial Paralysis”. The Turkish Journal of Ear Nose and Throat 30, sy. 4 (Aralık 2020): 118-22.
EndNote Göker AE, Karaketir S, Alagöz MH, Başkadem Yılmazer A, Sarı H, Bircan HS, Başaran N (01 Aralık 2020) The effect of vitamin D levels on prognosis of patients with facial paralysis. The Turkish Journal of Ear Nose and Throat 30 4 118–122.
IEEE A. E. Göker, “The effect of vitamin D levels on prognosis of patients with facial paralysis”, Tr-ENT, c. 30, sy. 4, ss. 118–122, 2020.
ISNAD Göker, Ayşe Enise vd. “The Effect of Vitamin D Levels on Prognosis of Patients With Facial Paralysis”. The Turkish Journal of Ear Nose and Throat 30/4 (Aralık 2020), 118-122.
JAMA Göker AE, Karaketir S, Alagöz MH, Başkadem Yılmazer A, Sarı H, Bircan HS, Başaran N. The effect of vitamin D levels on prognosis of patients with facial paralysis. Tr-ENT. 2020;30:118–122.
MLA Göker, Ayşe Enise vd. “The Effect of Vitamin D Levels on Prognosis of Patients With Facial Paralysis”. The Turkish Journal of Ear Nose and Throat, c. 30, sy. 4, 2020, ss. 118-22.
Vancouver Göker AE, Karaketir S, Alagöz MH, Başkadem Yılmazer A, Sarı H, Bircan HS, Başaran N. The effect of vitamin D levels on prognosis of patients with facial paralysis. Tr-ENT. 2020;30(4):118-22.