İrisin ve Egzersiz

Öz

Egzersizin sağlık durumunu olumlu yönde etkilediği, fiziksel uygunluğu artırdığı, kas metabolizmasını ve enerji homeostazisini düzenlediği bilinmektedir. Egzersizin endokrin sistem üzerindeki etkileri hormonların salınımı veya üretilmesi ile ilişkilidir. Bu süreçte bazı hormonların salınımı artarken bazılarında da azalır. Enerji metabolizması ve kas yenileme kapasitesi ile ilgili olan miyokinler, düzenli egzersizlerle aktif kaslara destek sağlamaktadırlar. Metabolik sistemlerin düzenlenmesinde hayati rol oynayan iskelet kasları, enerji tüketimindeki artışlarla ilişkili olduğu düşünülen irisin hormonunu salgılayan endokrin bir organdır. Yeni bir miyokin olan irisin, egzersiz sayesinde beyaz yağ dokularını daha fazla mitokondriye sahip olan kahverengi yağ dokularına dönüştürerek, vücut metabolizmasının düzenlenmesinde rol alır. İrisin, obezite ve tip 2 diyabet gibi metabolik hastalıkların önlenmesinde rol alabileceği fikrinin öne sürülmesi ile birlikte birçok araştırmacının ilgisini çekmiştir.  İrisin ve egzersiz arasındaki etki mekanizmasının tam olarak aydınlanması amacıyla birçok araştırma yapılmıştır. Bu derlemede enerji metabolizması ve egzersiz ile ilişkili olduğu öne sürülen irisin hormonu hakkında bilgi verilmiş ve yapılan çalışmalar özetlenmiştir

Anahtar Kelimeler

• irisin,myokin,egzersiz

Irisin and Exercise

Öz

It is known that exercise affects health status positively, increases physical fitness, regulates muscle metabolism and energy homeostasis. The effects of exercise on the endocrine system are associated with the production or secretion of hormones. In this process, some hormone secretion increases and some decrease. Myokines, which are related to energy metabolism and muscle regeneration capacity, support active muscles through regular exercises. Skeletal muscles, which play a vital role in the regulation of metabolic systems, are an endocrine organ that secretes the hormone iris, which is thought to be associated with increases in energy consumption. Irisin, a new myokine, plays a role in the regulation of body metabolism by transforming white fat tissues into brown fat tissues that have more mitochondria through exercise. It has attracted the attention of many researchers with the suggestion that iris may play a role in the prevention of metabolic diseases such as obesity and type 2 diabetes. Many studies have been conducted to clarify the mechanism of impact between irisin and exercise. In this review, information is given about irisin hormone which is suggested to be related with energy metabolism and exercise and the studies are summarized.

Anahtar Kelimeler

• Irisin,myokine,exercise

Kaynakça

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