Are obese rats influenced by GLP1 and IR through aerobic exercise? A case study

Öz

The present study aimed to consider the influence of aerobic exercise intensity on GLP-1and IR in obese rats. Glucagon-like peptide-1 (GLP-1) is characterized as incretion hormones secreted from the intestine upon ingestion of food to maximize insulin secretion, regulate blood sugar and enhance insulin resistance (IR). It was an in vitro study. The study subjects were thirty-two male Wistar rats which were divided into 4 groups: three levels of aerobic training intensity (high, moderate and low intensity) and one control group. Following 8 weeks of different intensity of aerobic trainings, the researchers calculated plasma concentration of glucose, insulin, HOMA-IR and GLP-1. We applied dependent t-test and Analysis of variance (ANOVA) to test the research hypotheses. Body weight, BMI, insulin, blood glucose and HOMA-IR in high, moderate and low intensity of aerobic training were noticed to be significantly lower than in the control group (P=0.001) following  an eight-week intervention. However, moderate and high intensity of aerobic training compared with low intensity significantly showed a decrease in insulin, blood glucose, HOMA-IR, and GLP-1. The findings revealed that moderate and high intensity of aerobic training results in GLP-1 secretion impairment, thus its improvement can cause a reduction in insulin resistance and blood glucose regulation.

Anahtar Kelimeler

• Aerobic exercise,glucagon-like peptide-1,swimming exercise

Kaynakça

1. Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care, 2007; 30(1): 89-94.
2. Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. Jama, 2007; 298(2): 194-206.
3. Balaguera-Cortes L, Wallman KE, Fairchild TJ, Guelfi KJ. Energy intake and appetite-related hormones following acute aerobic and resistance exercise. Applied Physiology, Nutrition, and Metabolism, 2011; 36(6): 958-966.
4. Boschmann M, Engeli S, Dobberstein K, Budziarek P, Strauss A, Boehnke J, et al. Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients. The Journal of Clinical Endocrinology & Metabolism, 2009; 94(3): 846-852.
5. Bozinovski NC, Bellissimo N, Thomas SG, Pencharz PB, Goode RC, Anderson GH. The effect of duration of exercise at the ventilation threshold on subjective appetite and short-term food intake in 9 to 14 year old boys and girls. International Journal of Behavioral Nutrition and Physical Activity, 2009; 6(1): 1.
6. Brown J, Dryburgh J, Ross S, Dupre J. Identification and actions of gastric inhibitory polypeptide. Recent Progress in Hormone Research, 1974; 31: 487-532.
7. Buchwald H, Dorman RB, Rasmus NF, Michalek VN, Landvik NM, Ikramuddin S. Effects on GLP-1, PYY, and leptin by direct stimulation of terminal ileum and cecum in humans: implications for ileal transposition. Surgery for Obesity and Related Diseases, 2014; 10(5): 780-786.
8. Cegla J, Troke RC, Jones B, Tharakan G, Kenkre J, McCullough KA, et al. Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake. Diabetes, 2014; 63(11): 3711-3720.

9. Deighton K, Zahra JC, Stensel DJ. Appetite, energy intake and resting metabolic responses to 60min treadmill running performed in a fasted versus a postprandial state. Appetite, 2012; 58(3): 946-954.
10. Delgado-Aros S, Kim D-Y, Burton DD, Thomforde GM, Stephens D, Brinkmann BH, et al. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2002; 282(3): G424-G31.
11. Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes preclinical biology and mechanisms of action. Diabetes Care. 2007; 30(6): 1335-1343.
12. Elahi D, Ruff DA, Carlson OD, Meneilly GS, Habener JF, Egan JM. Does GLP-1 suppress its own basal secretion? Endocrine Research, 2016; 41(1): 16-20.
13. Fadini GP, Avogaro A. Cardiovascular effects of DPP-4 inhibition: beyond GLP-1. Vascular Pharmacology, 2011; 55(1): 10-16.
14. Fernström M, Tonkonogi M, Sahlin K. Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. The Journal of Physiology, 2004; 554(3): 755-763.
15. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation, 2005; 112(17): 2735-2752.
16. Hagobian TA, Braun B. Physical activity and hormonal regulation of appetite: sex differences and weight control. Exercise and Sport Sciences Reviews, 2010; 38(1): 25-30.
17. Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Silva JE, Chipkin SR, et al. Effects of exercise on energy-regulating hormones and appetite in men and women. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2009; 296(2): R233-R42.
18. Heni M, Kullmann S, Gallwitz B, Häring H-U, Preissl H, Fritsche A. Dissociation of GLP-1 and insulin association with food processing in the brain: GLP-1 sensitivity despite insulin resistance in obese humans. Molecular Metabolism, 2015; 4(12): 971-976.
19. Herrmann C, Göke R, Richter G, Fehmann H-C, Arnold R, Göke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion, 1995; 56(2): 117-126.
20. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. American Journal of Physiology-Endocrinology and Metabolism, 2004; 287(2): E199-E206.
21. Horner KM, Schubert MM, Desbrow B, Byrne NM, King NA. Acute exercise and gastric emptying: a meta-analysis and implications for appetite control. Sports Medicine, 2015; 45(5): 659-678.
22. Houmard JA, Cox JH, MacLean PS, Barakat HA. Effect of short-term exercise training on leptin and insulin action. Metabolism, 2000; 49(7): 858-861.
23. Howe SM, Hand TM, Larson-Meyer DE, Austin KJ, Alexander BM, Manore MM. No effect of exercise intensity on appetite in highly-trained endurance women. Nutrients, 2016; 8(4): 223.
24. Idorn T, Knop FK, Jørgensen MB, Christensen M, Holst JJ, Hornum M, et al. Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease. The Journal of Clinical Endocrinology & Metabolism, 2014; 99(7): 2457-2466.
25. Kampmann U, Mosekilde L, Juhl C, Moller N, Christensen B, Rejnmark L, et al. Effects of 12weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency–a double-blind, randomized, placebo-controlled trial. Metabolism, 2014; 63(9): 1115-1124.
26. Knop FK, Lund A, Madsbad S, Holst JJ, Krarup T, Vilsbøll T. Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report. BMC Research Notes, 2014; 7(1): 1.
27. Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nature Reviews Endocrinology, 2009; 5(5): 262-269.
28. Maino B, Ciotti MT, Calissano P, Cavallaro S. Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide. International Journal of Molecular Sciences, 2014; 15(4): 5596-5622.
29. Martins C, Morgan LM, Bloom SR, Robertson MD. Effects of exercise on gut peptides, energy intake and appetite. Journal of Endocrinology, 2007; 193(2): 251-258.
30. Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, et al. Effect of moderate-and high-intensity acute exercise on appetite in obese individuals. Medicine & Science in Sports & Exercise, 2015; 47(1): 40-48.
31. Mougios V, Kazaki M, Christoulas K, Ziogas G, Petridou A. Does the intensity of an exercise programme modulate body composition changes? International Journal of Sports Medicine, 2006; 27(03): 178-181.
32. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. Jama, 2014; 311(8): 806-814.
33. Pilegaard H, Ordway GA, Saltin B, Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. American Journal of Physiology-Endocrinology and Metabolism, 2000; 279(4): E806-E14.
34. Pomerleau M, Imbeault P, Parker T, Doucet E. Effects of exercise intensity on food intake and appetite in women. The American Journal of Clinical Nutrition, 2004; 80(5): 1230-1236.
35. Sjøberg KA, Rattigan S, Jeppesen JF, Lundsgaard AM, Holst JJ, Kiens B. Differential effects of glucagon‐like peptide‐1 on microvascular recruitment and glucose metabolism in short‐and long‐term insulin resistance. The Journal of Physiology, 2015; 593(9): 2185-2198.
36. Slentz CA, Duscha BD, Johnson JL, Ketchum K, Aiken LB, Samsa GP, et al. Effects of the amount of exercise on body weight, body composition, and measures of central obesity: Strride—a randomized controlled study. Archives of Internal Medicine, 2004; 164(1): 31-39.
37. Steinert RE, Schirra J, Meyer-Gerspach AC, Kienle P, Fischer H, Schulte F, et al. Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men. The American Journal of Clinical Nutrition, 2014; 100(2): 14-23.
38. Stubbs RJ, Sepp A, Hughes DA, Johnstone AM, Horgan GW, King NA, et al. The effect of graded levels of exercise on energy intake and balance in free-living men, consuming their normal diet. European Journal of Clinical Nutrition, 2002; 56: 129-140.
39. Symons Downs D, Evenson KR, Chasan-Taber L, editors. Obesity and physical activity during pregnancy and postpartum. Springer-Verlag London Ltd; 2014.
40. Thompson DA, Wolfe LA, Eikelboom R. Acute effects of exercise intensity on appetite in young men. Medicine and Science in Sports and Exercise, 1988; 20(3): 222-227.
41. Tsukiyama K, Yamada Y, Yamada C, Harada N, Kawasaki Y, Ogura M, et al. Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion. Molecular Endocrinology, 2006; 20(7): 1644-1651.
42. Ueda S-y, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S. Changes in gut hormone levels and negative energy 42 balance during aerobic exercise in obese young males. Journal of Endocrinology, 2009; 201(1): 151-159.
43. Van Engelen M, Khodabandeh S, Akhavan T, Agarwal J, Gladanac B, Bellissimo N. Effect of sugars in solutions on subjective appetite and short-term food intake in 9-to 14-year-old normal weight boys. European Journal of Clinical Nutrition, 2014; 68(7): 773-777.
44. Verger P, Lanteaume M, Louis-Sylvestre J. Free food choice after acute exercise in men. Appetite, 1994; 22(2): 159-164.
45. Westerterp-Plantenga MS, Verwegen CR, IJedema MJ, Wijckmans NE, Saris WH. Acute effects of exercise or sauna on appetite in obese and nonobese men. Physiology & Behavior, 1997; 62(6): 1345-1354.
46. Yazbeck R. Teduglutide, a glucagon-like peptide-2 analog for the treatment of gastrointestinal diseases, including short bowel syndrome. Current Opinion in Molecular Therapeutics, 2010; 12(6): 798-809.