Comparison of Plasma NPY and Zinc Levels of Elite Weightlifters and Sedentaries

Öz

Neuropeptide Y (NPY), a strong stimulant of nutrition, and zinc, which has an important effect on nutrition regulation, have attracted the attention of many researchers. The aim of this study was to investigate the relationship between plasma NPY and zinc levels in elite weightlifters. Thirty healthy subjects between the ages of 18-27 participated in the study voluntarily. The subjects were composed of two equal groups: the control group who did not exercise regularly and the elite weightlifters who did regular training. Plasma NPY (ELISA) and zinc levels (Atomic Absorption Spectrophotometer) were determined in blood samples collected from subjects. When serum NPY and zinc values were compared between the groups, it was found that NPY levels of elite weightlifters were higher than controls (p <0.01) and zinc levels were lower (p <0.01). The findings of the study show that physical activity leads to changes in NPY and zinc release. As a result, there may be a critical relationship between these changes and physical performance.

Anahtar Kelimeler

• Elite Weightlifter
• Sedentary
• NPY
• Zinc

Kaynakça

1. 1. Baltaci AK, Moğulkoc R. Leptin, NPY, melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: The relation to zinc. Biochem Genet, 2017; 55: 223-233, https://doi.org/10.1007/s10528-017-9791-z.
2. 2. Campbell WW, Anderson RA. Effects of aerobic exercise and training on the trace minerals chromium, zinc and copper. Sports Med, 1987; 4: (1): 9-18, https://doi.org/10.2165/00007256-198704010-00002.
3. 3. Chen JX, Zhao X, Wang ZF. Infuence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1–13. Cell Mol Neurobiol, 2007; 27:1-10, https://doi.org/10.1007/s10571-006-9110-4.
4. 4. Chu A, Petocz P, Samman S. Plasma/serum zinc status during aerobic exercise recovery: a systematic review and meta-analysis. Sports Med, 2017; 47(1): 127-134, https://doi.org/10.1007/s40279-016-0567-0.
5. 5. Cordova A, Alvarez-Mon M. Behaviour of zinc in physical exercise, a special reference to immunity and fatigue. Neurosci Biobehav Rev, 1995; 19: 439-445, https://doi.org/10.1016/0149-7634(95)00002-V.
6. 6. Cordova A, Navas FJ. Effect of training on zinc metabolism: changes in serum and sweat zinc concentrations in sportsmen. Ann Nutr Metab, 1998; 42 (5): 274-282.
7. 7. Diaz-delCastillo M, Woldbye DPD, Heegaard AM. Neuropeptide Y and its involvement in chronic pain. Neuroscience, 2018;387:162-169, https://doi.org/10.1016/j.neuroscience.2017.08.050
8. 8. El-Shazly AN, Ibrahim SA, El-Mashad GM, Sabry JH, Sherbini NS. Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients. Int J Nephrol Renovasc Dis, 2015; 8: 159-163, https://doi.org/ 10.2147/IJNRD.S94923.

9. 9. Faraji H, TaghipoorAsrami A, Jalali SF, Enferadi F. The effect of concurrent exercise on PYY and NPY plasma levels in obese men. Tabari J Preventive Med, 2016; 2(1): 48-58.
10. 10. Haralambie G. Serum zinc in athletes in training. Int J Sports Med, 1981;2(3):135-138, https://doi.org/10.1055/s-2008-1034599.
11. 11. Huang L, Li X, Wang W, Yang L, Zhu Y. The role of zinc in poultry breeder and hen nutrition: an update. Biol Trace Elem Res, 2019; 192 (2): 308-318, https://doi.org/10.1007/s12011-019-1659-0.
12. 12. Karamouzis I, Karamouzis M, Vrabas IS, Christoulas, K, Kyriasis N, Giannoulis E, Mandroukas K. The effects of marathon swimming on serum leptin and plasma neuropeptide Y levels. Clin Chem Lab Med, 2002;40:132-136, https://doi.org/10.1515/CCLM.2002.023.
13. 13. Khaled S, Brun JF, Cassanas G, Bardet I, Orsetti A. Effects of zinc supplementation on blood rheology during exercise. Clin Hemorheol Microcirc,1999; 20(1): 1-10.
14. 14. Lee RG, Rains TM, Tovar-Palacio C, Beverly JL, Shay NF. Zinc deficiency increases hypothalamic neuropeptide Y and neuropeptide Y mRNA levels and does not block neuropeptide Y-induced feeding in rats. J Nutr 1998; 128:1218-1223, https://doi.org/10.1093/jn/128.7.1218.
15. 15. Li YV. Zinc and insulin in pancreatic beta-cells. Endocrine, 2014;45(2):178-189, https://doi.org/10.1007/s12020-013-0032-x.
16. 16. Maynar M, Muñoz D, Alves J, Barrientos G, Grijota FJ, Robles MC, Llerena F. Influence of an acute exercise until exhaustion on serum and urinary concentrations of molybdenum, selenium, and zinc in athletes. Biol Trace Elem Res, 2018; 186 (2): 361-369, https://doi.org/10.1007/s12011-018-1327-9.
17. 17. McClung JP. Iron, zinc and physical performance. Biol Trace Elem Res, 2019;188(1):135-139, https://doi.org/10.1007/s12011-018-1479-7.
18. 18. Ramson R, Jürimae J, Jürümae T, Maestu J. The effect of 4-week training priod on plasma neuropeptide Y, leptin and ghrelin responsen in male rowers. Eur J Appl Phsiol, 2012;112:1873-1880, https://doi.org/10.1007/s00421-011-2166-y.
19. 19. Ruegsegger GN, Speichinger KR, Manier JB, Younger KM, Childs TE, Booth FW. Hypothalamic Npy mRNA is correlated with increased wheel running and decreased body fat in calorie-restricted rats. Neurosci Lett, 2016; 618:83-88, https://doi.org/10.1016/j.neulet.2016.02.037.
20. 20. Safai-Kutti S. Oral zinc supplementation in anorexia nervosa. Acta Psychiatr Scand Suppl, 1990; 361:14-17.
21. 21. Selvais PL, Labuche C, Nguyen XN, Ketelslegers JM, Denef JF, Maiter DM. Cyclic feeding behaviour and changes in hypothalamic galanin and neuropeptide Y gene expression induced by zinc deficiency in the rat. J Neuroendoc, 1997; 9: 55-62, https://doi.org/10.1046/j.1365-2826.1997.00566.x.
22. 22. Severo JS, Morais JBS, de Freitas TEC, Andrade ALP, Feitosa MM, Fontenelle LC, de Oliveira ARS, Cruz KJC, do Nascimento Marreiro D. The role of zinc in thyroid hormones metabolism. Int J Vitam Nutr Res, 2019;89;1(2): 80-88, https://doi.org/10.1024/0300-9831/a000262.
23. 23. Shay NF, Mangian HF. Neurobiology of zinc-influenced eating behavior. J Nutr, 2000;130:1493-1499, https://doi.org/10.1093/jn/130.5.1493S.
24. 24. Shin MS, Kim H, Chang HK, Lee TH, Jang MH, Shin MC, Lim BV, Lee HH, Kim YP, Yoon JH, Jeong G, Kim, CJ. Treadmill exercise suppresses diabetes induced increment of neuropeptide Y expression in the hypothalamus of rats. Neurosci Lett, 2003; 346:157-160, https://doi.org/10.1016/S0304-3940(03)00537-8.
25. 25. Suzuki H, Asakawa A, Li JB, Tsai M, Amitani H, Ohinata K, Komai M, Inui A. Zinc as an appetite stimulator-the possible role of zinc in the progression of diseases such as cachexia and sarcopenia. Recent Pat Food Nutr Agric, 2011; 3(3): 226-31.
26. 26. Swain PS, Rao SBN, Rajendran D, Dominic G, Selvaraju S. Nano zinc, an alternative to conventional zinc as animal feed supplement: A review. Anim Nutr,2016;2(3):134-141, https://doi.org/10.1016/j.aninu.2016.06.003.
27. 27. Tannhauser, PP. Anorexia nervosa: a multifactorial disease of nutritional origin?, Int J Adolesc Med Health, 2002;14(3): 185-191, https://doi.org/10.1515/IJAMH.2002.14.3.185.
28. 28. Thomas DT, Erdman KA, Burke LM. Position of the academy of nutrition and dietetics, dietitians of Canada and the American college of sports medicine: Nutrition and athletic performance. J Acad Nutr Diet, 2016; 116(3): 501-528, https://doi.org/10.1016/j.jand.2015.12.006.
29. 29. Tipton K, Green NR, Haymes EM, Waller M. Zinc loss in sweat of athletes exercising in hot and neutral temperatures. Int J Sports Med, 1993; 3(3): 261-271, https://doi.org/10.1123/ijsn.3.3.261.
30. 30. Zhang W, Cline MA, Gilbert ER. Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism. Nutr Metab,2014; 10: 11-27. https://doi.org/10.1186/1743-7075-11-27