Effect of l-carnıtıne used ın regular exercıse ın elderly obesıs rats

Yıl 2019, Cilt: 21 Sayı: 1, 74 - 77, 30.04.2019

İbrahim Kubilay Türkay Aynur Başalp

https://doi.org/10.15314/tsed.552115

Öz

The aim of this study was to investigate the
effect of L-Caritine supplemented elderly rats on weight loss during 12 weeks.
This experimental study was carried out on experimental animals in a scientific
laboratory environment, under defined conditions and according to the method of
application. Therefore, the model of the research is an experimental research
model. In this study, 8 obese aged rats were used for 20 months. Approximately
70 years of human life is equivalent. The rats were given special cholesterol
food for obesity. In the study, L-Carnitine was administered to the experimental
group 3 times a week just before the exercise, with the daily dose of the
sublingual fluid administered to the rats in a suitable dose (1 gr./kg). Before
the exercise + L-Carnitine application, weight measurements of the rats were
recorded at the beginning of the study (day 1), in the middle of the study (day
45) and finally at the end of the study (day 90). The “IBM SPSS Statistics 22
analiz package program was used to evaluate the statistical analysis of the
study. Normal distribution assumptions were evaluated with Kolmogorov-Smirnov
and Shapiro-Wilk tests. In the rare cases where the two tests are
contradictory, the Kolmogorov-Smirnov test result, which is more preferred in
small data sets, was used. Type 1 error margin for normality tests is taken as
0.05. At the end of the study, it was determined that the weight of the old
obese rats who used L-Carnitine together with the regular exercise for 12
weeks, both on the 45th and 90th days, was found.

Anahtar Kelimeler

Elderly obese, Rat, Regular exercise, L-carnitine

Kaynakça

• 1. Adams, S. H., Hoppel, C. L., Lok, K. H., Zhao, L., Wong, S. W., et al. (2009). Plasma acylcarnitine profiles suggest incomplete long‐chain fatty acid beta‐oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African‐American women. J. Nutr. 139, 1073–1081.
• 2. Artıs, A.S. (2009). The Relationship Between Proinflammatory Cytokines and Brain Natriuretic Peptide (Bnp) Level in Acute Intensive Exercise, (Unpublished Specialization Thesis), Erciyes University Faculty of Medicine, Department of Physiology, Kayseri, Turkey; 3, 5, 16, 17, 60.
• 3. Brownell, KD., Wadden, TA. (1992). Etiology and treatment of obesity: Towards understanding a serious, prevalent and refractory disorder. J Consult Clin Psychol, 60: 505-17.
• 4. Halliwell, B. (2001). Free radicals and other reactive species in disease. In: Encyclopedia of life sciences. Ed: J. Wiley & Sons; London: Nature Publishing Group; 1-7.
• 5. Hoppel, C. L., and Genuth, S. M. (1980) Carnitine metabolism in normal‐weight and obese human subjects during fasting. Am. J. Physiol. 238, E409–E415.
• 6. Hoppel, C. L., and Genuth, S. M. (1982). Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am. J. Physiol. 243, E168–E172.
• 7. Lee, B. J., Lin, J. S., Lin, Y. C. & Lin, P. T. (2016). Effects of l‐carnitine supplementation on lipid profiles in patients with coronary artery disease. Lipids Health Dis. 15, 107.
• 8. Lindeboom, L., Nabuurs, C. I., Hoeks, J., Brouwers, B., Phielix, E. & al. (2014). Long‐echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. J. Clin. Invest. 124, 4915–4925.
• 9. Odland, L. M., Heigenhauser, G. J., Wong, D., Hollidge‐Horvat, M. G. & Spriet, L. L. (1998). Effects of increased fat availability on fat‐carbohydrate interaction during prolonged exercise in men. Am. J. Physiol. 274, R894–R902.
• 10. Roepstorff, C., Halberg, N., Hillig, T., Saha, A. K., Ruderman, N. B. & al. (2005). Malonyl‐CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am. J. Physiol. Endocrinol. Metab. 288, E133–E142.
• 11. Saygın, O. (2003). Investigation of Physical Activity Levels and Physical Fitness of 10. 12 Years Old Children. Sıpirdusa: PhD Thesis. Marmara University, Institute of Health Sciences.
• 12. Stone, M.H. (1994). Eating Disorders. Essentials of Strength Training and Contitioning. (Ed. Baechle TR). Canada: Human Kinetics. 238–239.
• 13. Yaprak, Y. (2004). Effects of Aerobic and Strength Study on Oxygen Use and Cardiac Flow in Obese Women. Journal of Physical Education and Sport Sciences. II (2): 73-80.
• 14. Zhao, G., Zhou, S., Davie, A. & Su, Q. (2012). Effects of moderate and high intensity exercise on T1/T2 balance. Exerc. Immunol. Rev. 18, 98–114.