PROTECTIVE EFFECTS OF CARVACROL ON MORTALITY AND VASCULAR INJURY IN SEPSIS

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 55 - 55, 16.02.2017

Erdem Kamil Ozer Mustafa Tugrul Goktas

Öz

Carvacrol (CRV) is
a botanical agent that has antioxidant, anti-inflammatory, antimicrobial,
antibacterial, antiapoptotic, anti-platelet, antiproliferative and
anti-carcinogenic properties. In sepsis process massively and uncontrolled
inflammation, oxidative injury, coagulative necrosis and hypoperfusion are
responsible for vascular dysfunction and death. We hypothesized that CRV may be
protective from vascular injury and high mortality in sepsis.

57 Wistar albino
rats were divided into four groups; sham (SHM), cecal ligation and puncture
(septic rats, CLP), SHM+CLP (SHMCRV), CLP+CRV (CLPCRV). For 7 days rats were
given with CRV (80 mg/kg/day, o.g.) in SHMCRV and CLPCRV groups or vehicle in
SHM and CLP groups. At 8th day animals were underwent CLP and SHM operations.
In 26 rats 20 hours after the operations mesenteric arterial blood flow (MBF)
and phenylephrine responses of isolated aortic rings were measured. In 29 rats
survival study was performed.

Phenylephrine
responses of isolated aortic contractions and MBF decreased in CLP groups that were prevented by CRV pretreatment. Survival
rate decreased in CLP group (p<0,001) that was partially restored by CRV.

CoQ10 has preventive
effects on sepsis mortality, vascular dysfunction and tissue injury possibly due
to its antioxidant, anti-inflammatory, antimicrobial, antiapoptotic,
anti-platelet properties. 

Anahtar Kelimeler

PROTECTIVE EFFECTS OF CARVACROL ON MORTALITY AND VASCULAR INJURY IN SEPSIS

Kaynakça

• Selcuk University, Faculty of Medicine, Department of Pharmacology, Konya, Turkey
• Yildirim Beyazit University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey