MECHANISMS OF NANOMATERIAL INDUCED INFLAMMATION

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 77 - 77, 16.02.2017

Harri Alenıus

Öz

Engineered
nanomaterials (ENM) have characteristics that are unique to material offering
numerous possibilities to improve the properties of old products and create
completely new ones. The rapidly expanding use of ENM will bring hundreds of
millions of people in contact with ENM during the next few years.  Due to the worldwide use of nanotechnologies,
it is crucial to acquire up-to-date knowledge on health effects to avoid any
potential risks.

Some of the
properties that make ENM so unique and beneficial for technological
applications may also endanger human health through the potential induction of
cytotoxicity, inflammation and even cancer. These features include a large
surface area to mass ratio, increased surface reactivity, altered
physico-chemical properties, electrical conductivity, or changes in the
crystalline structure of the ENM.

Evidence already
exits that exposure to certain type of ENM elicit adverse health effects in
experimental models, thus justifying the precautionary approach in assessing
risks of ENM. Such effects include the ENM induced pulmonary inflammation in
experimental animals. In addition, recent observations reveal that needle-like
fibrous CNT may induce asbestos-like granuloma formation and increase the
likelihood of mesotheliomas in tumor prone mouse strain. In addition to healthy
individuals, a large part of the population has impaired health conditions that
may make them more susceptible to develop health problems from ENM exposure.

In this
presentation recent understanding on the mechanisms of ENM induced inflammation
will be discussed.  It will be also
discussed how exposure to ENM affects on vulnerary population such as patients
with allergic diseases. 

Anahtar Kelimeler

MECHANISMS OF NANOMATERIAL INDUCED INFLAMMATION

Kaynakça

• Harri ALENIUS Systems Toxicology Team and Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland