APPLYING THE EXPOSOME CONCEPT IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 80 - 80, 16.02.2017

Jelle Vlaanderen

Öz

The “exposome”
concept encompasses the totality of environmental (non-genetic) exposures from
conception onwards, complementing the genome. 
Developments following the introduction of the exposome concept offer
unprecedented opportunities for discovery of the causes and mechanisms of
disease. New technologies such as the so-called “OMICS” biomonitoring
approaches, but also the inventive use of existing exposure data can contribute
to defining and measuring the exposome. Challenges in developing the exposome
concept into a workable approach for epidemiological research include the
integration of exposure uncertainty and variability, the integration of omics
techniques, and the development of statistical techniques that can analyze the
associations between exposome data and adverse health end points. Various
European projects (e.g. ExposOmics, Helix) have started to implement the
exposome, promising more integrated, holistic, ways of studying the environment
over the life course. I will present examples from studies of both occupational
and environmental exposures in which we applied the exposome concept, will
discuss which difficulties we encountered, and will highlight where further
research is needed. 

Anahtar Kelimeler

APPLYING THE EXPOSOME CONCEPT IN STUDIES OF OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES

Kaynakça

• Jelle VLAANDEREN Institute of Risk Assessment Sciences, Uthrect University, The Netherlands