MOLECULAR AUTOPSY: GENERAL OVERVIEW AND APPLICATION

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 81 - 81, 16.02.2017

Gokhan Ersoy

Öz

Autopsy is an
important tool in legal and medical area. Performing an autopsy has so benefits
at the point of research, education and determining the cause and manner of
death. Decision process at autopsy could be supported by molecular studies on
DNA, RNA or proteomic content of the cells. Some of these works are still
largely on research level, rather than a routine application.

One of the most
attractive topic in Molecular autopsy (MA) is sudden cardiac death at young
people and children.  Many cardiac
conduction pathologies and cardiomyopathies has genetic basis, so diagnosing
them by MA and informing the relatives would be warning. Pharmacogenetics is
another field for MA. Genetic differences in metabolizing rate of drugs may
lead diverse clinic results; including unexpected death. It would be important
to demonstrate this genomic structure in suspect of both legal and illegal drug
consuming.

MA can also be
useful for determining the manner and cause of death. Especially, asphyxia and
violent deaths are most studied issues, in regard of differentiating the
mechanism of death. Researches on human biologic clock may reveal clues for
right estimation of time of death, in proximate future. Identification analysis
of different body fluids and tissues has already done by several laboratories.
Ongoing studies give hope to expose safe and clear results to be used.

Anahtar Kelimeler

MOLECULAR AUTOPSY: GENERAL OVERVIEW AND APPLICATION

Kaynakça

• Gokhan ERSOY Institute of Forensic Medicine, Istanbul University, Turkey