HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EFFECTS OF MYRICETIN ON LIVER, KIDNEY AND ENDOCRINE GLANDS OF MALE RATS AT PREPUBERTAL PERIOD

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 190 - 190, 16.02.2017

Nurhayat Barlas Gözde Karabulut Burcu Öztaşcı

Öz

Myricetin, a
natural flavonol with hydroxyl groups at 3, 5, 7, 3′, 4′ and 5′ positions, is
commonly ingested through human diets such as fruits, vegetables, tea, berries
and red wine. In this study, the effects of myricetin exposure to rats from
postnatal day (PND) 23 to 53 at various doses were investigated.

The male rats
were divided into five groups and each group consisted of six animals. Group of
rats were treated with myricetin 25 and 50 mg/kg body weight /day in a
suspension of corn oil. Positive control males were gavage orally with
17α-ethinyl estradiol 0.7 and 7 µg/kg body weight/day and control males were
received corn oil only. End of the study, weights of liver, kidney, spleen,
pancreas, thymus and adrenal gland were measured. Organ/body weight ratios were
calculated and tissue sections were examined histologically. In liver, the
TUNEL method was applied and evaluated.

This study demonstrated that orally
gavages myricetin caused adverse effects on male liver, kidney and endocrine
glands, during peripubertal period to pubertal period.

Anahtar Kelimeler

HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL EFFECTS OF MYRICETIN ON LIVER

Kaynakça

• Nurhayat BARLAS, Gözde KARABULUT, Burcu ÖZTAŞCI
• Hacettepe University, Science Faculty, Department of Biology, 06800, Beytepe Campus