SUBCHRONIC TOXICITY OF HEAT-INDUCED FOOD CONTAMINANT ACROLEIN IN HEMATOLOGICAL PARAMETERS AND HORMONE LEVELS IN PREPUBERTAL MALE RATS

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 193 - 193, 16.02.2017

Elif Karacaoğlu Güldeniz Selmanoğlu

Öz

Acrolein as a
heat-induced food contaminant is a highly reactive α,β aldehyde. It is known to
be formed by thermal processing of carbohydrates, amino acids and fats. Its
presence was found in fruits and vegetables. Human may expose to acrolein via
oral or respiratory and dermal routes. In the present study, our aim is to
evaluate subchronic effects of acrolein on hematological parameters as well as
serum LH and testosterone levels in male rats.

Weaning Wistar
male rats were administered 0.5, 1 and 2 mg/kg/day acrolein orally for 90 days.
At the end of the administration, rats were sacrified and blood samples were
taken from hearts for analyses. Hematologic parameters were analysed, also
serum LH and testosterone levels were measured spectrophotometrically by Elisa
method. As a result of acrolein administration, significant alterations were
observed in number of leukocytes, percentage of hematocrite, MCH, MCHC,
thrombocytes and percentage of PCT. Although alterations were observed in serum
LH in acrolein administrated groups, these were not statistically significant.
Testosterone levels of acrolien administrated rats were not different from rats
in control group.

As a conclusion,
we may suggest that subchronic intake of acrolein may cause alterations in
hematologic parameters, but not serum LH and testosterone levels.

 

 

This research is partially supported by
Scientific Research Project Coordination Unit of Hacettepe University (Project
no: 010D08601008, 013D04601001).

Anahtar Kelimeler

SUBCHRONIC TOXICITY OF HEAT-INDUCED FOOD CONTAMINANT ACROLEIN IN HEMATOLOGICAL PARAMETERS AND HORMONE LEVELS IN PREPUBERTAL MALE RATS

Kaynakça

• Elif KARACAOĞLU, Güldeniz SELMANOĞLU, Gökçen MÜLAYIMÇELIK ÖZGÜN
• Hacettepe University, Faculty of Science, Department of Biology, 06800, Beytepe, Ankara, TURKEY