EVALUATION OF THE RELATIONSHIP BETWEEN OBESITY AND ENDOCRINE DISRUPTING CHEMICALS. PHTHALATES AND BISPHENOL A

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 196 - 196, 16.02.2017

Leila Shahvırdı Timur Gültekın

Öz

Obesity is defined as a case in which body-mass index is
over 30. Obesity and Metabolic disorders are increasing health problem in
recent days. Endocrine disruptings are synthetic or natural substance damaging
body's normal physiological functions by imitating or preventing hormones. They
show their effects by increasing the metabolism of endogen peptidic or
steroidal hormones; or activating or deactivating the receptors on
hypothalamus, adiposis tissue, liver and the other tissues. They can be present
in the environment both as a result of industrial production and naturally.
These substances are thought to affect some basic process like growth, stress
response, sex development, capability of reproduction, forming and using
insulin and Metabolic speed by unbalancing equilibrium. Ftalats and bisfenol A
are plastizer substance that are widely used in the process of producing of
variety consumer goods. They are extensively used in the food packaging, materials
which contact with food, cosmetics, toys, bags, drugs, medical equipment and
material of construction.  DEHP is mostly
used phthalate derivative and considered to have possible carcinogenic effects
on human. In the researches this phthalate derivative is considered to cause
testicular disgenesis syndrome in animal and possibly human. Detecting of these
substances in the urine, blood and in the tissues shows us that there is a
contact with these materials via oral, inhalation, dermal route.   The effects of phthalates and BPA on the
Obesity and the adipogenesis are discussed by showing datas of in vitro,
animal, animals. The latest in vivo and in vitro researches provide evidences
supporting that contamination of individuals with the chemicals lead to Obesity
epidemic. Animal datas and few human studies show that phthalates lead to
obesity with the various biological mechanisms such as activation of PPAR,
antiandrogenic effect and thyroid hormone inhibation. It is reported that there
are lots of mechanism of why BPA also lead to obesity and also that BPA shows oestrogenic
effect in vivo and in vitro researches.  In
addition to that, BPA can have some effect causing Insulin resistance and body
fat forming.  With the exposure to
oestrogenic chemicals in the critical phase of development, there can be some
unprecedented changes in the adipose tissue. Additionally, it is shown that BPA
lead to some metabolic changes and increase the formation of the fat cell and
accumulation of the lipid in mature fat cell with the factor of adipocyte
spesific gene and transcription such as PPAR and lipoprotein lipase.

 

Anahtar Kelimeler

EVALUATION OF THE RELATIONSHIP BETWEEN OBESITY AND ENDOCRINE DISRUPTING CHEMICALS. PHTHALATES AND BISPHENOL A

Kaynakça

• Leila SHAHVIRDI, Timur GÜLTEKIN
• Ankara University Institute of Social Sciences, Department of Physical Anthropology Ankara University Faculty of Language, History and Geography, Department of Anthropology