THE RELATIONSHIP BETWEEN FORENSIC PHARMACOLOGY-GENETICS AND NANOTECHNOLOGY

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 240 - 240, 16.02.2017

Filiz Ekim Çevık Esma Cansu Çevık Selda Mercan Faruk Aşıcıoğlu

Öz

Forensic
pharmacology is defined as a multidisciplinary field, which requires obtaining
knowledge in not only in pharmacology, but also in he legal aspects, which
therefore covers a wide area and where a different knowledge is required. On
the other hand, the field that analyzes the changes in the reactions of the
people to the drugs due to the variations in their genetic structure is called
pharmacogenetics.  In a general
definition, these polymorphisms associated with the variability in the
reactions to the drug can be divided into two as pharmacokinetics and
pharmacodynamics. When pharmacokinetics changes, course of the drug within the
body changes. This genetic difference in the enzymes playing role in
elimination and/or metabolism of the drug is important. Thus, when these
enzymes are much, the drug will be metabolized rapidly and if the concerned
drug is not prodrug, then its period of effect or effect will reduce. This way,
differences among the persons having the same drug will arise. Thanks to
pharmacogenetic researches, in the light of the illnesses and information on
the genes, it will be possible to create drugs treating illnesses. In addition
to these, one of the new elements brought along by nanotechnology is the
nanostructures that were developed to achieve the cell-specific gene transfer
for improving specificity of the treatment. These researches not only will
maximize the effects of treatment, but also will reduce the possibility of
damage to the healthy cells. This research we conducted will address different
examples in this field.

 

Anahtar Kelimeler

THE RELATIONSHIP BETWEEN FORENSIC PHARMACOLOGY-GENETICS AND NANOTECHNOLOGY

Kaynakça

• Filiz Ekim ÇEVIK, Esma Cansu ÇEVIK, Selda MERCAN, Faruk AŞICIOĞLU
• Istanbul University, Institute of Forensic Sciences