Nickel is a
potential carcinogenic and very common cause of allergic contact dermatitis.
Human are exposed to nickel primarily via inhalation, ingestion and dermal
absorption. The most encountered nickel exposure sources for general population
are foods, cigarette, jewellery, cosmetics, metal coins, etc. Low concentrated
nickel-plated objects may cause chronic accumulation in the body as a result of
recurrent contacts. On the other hand, urine is the best indicator of chronic
accumulation as an evidence for the exposure to nickel. To the best of our
knowledge, in our country, there hasn’t been a reported study about the urinary
nickel concentrations of nickel sensitized individuals compared in
non-sensitive individuals yet. The aim of this study was to compare the nickel
concentration in urine of patients whose nickel-sensitivity was
dermatologically proven, with non-sensitive group. Nickel patch test was
applied to 388 (61.6% of men) volunteer in dermatology policlinics of
Cerrahpasa Medical Faculty. Test results were positive in 92 (23,7%)
participants. Urine samples were also collected from all participants and
nickel concentrations were determined by Inductively Coupled Plasma-Mass
Spectrometry (ICP-MS). Mean concentrations of nickel-sensitive and non
sensitive people were found 4.48 and 4.26 µg/g creatinine respectively.
Although a significant difference was not found between two groups according to
nickel concentration in urine (p=0.068), results showed that nickel-sensitive
people have higher concentration of nickel in urine than other group as related
studies reported in other countries. This is the first comparative study
evaluating the relationship between urine nickel concentration and nickel
sensitivity in Turkey.
URINE NICKEL CONCENTRATIONS OF NICKEL-SENSITIVE PATIENTS: A COMPARATIVE STUDY IN TURKEY
Bölüm | Articles |
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Yazarlar | |
Yayımlanma Tarihi | 16 Şubat 2017 |
Yayımlandığı Sayı | Yıl 2017 Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology |