EVALUATION OF MEASUREMENT UNCERTAINTY FOR CARBAMAZEPINE

Yıl 2017, Cilt: Volume 2 Sayı: İssue 1 (1) - 2.İnternational Congress Of Forensic Toxicology, 261 - 261, 16.02.2017

Almila Şenat Serpil Erdogan Ceylan Bal Orhan Sen Pervin Baran Ozcan Erel

Öz

Uncertanty
measurement is defined as “a parameter associated with the result of a
measurement, that characterises the dispersion of the values that could
reasonably be attributed to the measurand”. The objectiveness of this study,
calculate measurement uncertainty of carbamazepine by using internal quality
control data and inter laboratory results to compare these calculated
measurement uncertainties with total allowable error % (TEa %) value of
CLIA'88.

In this study
was done by the internal quality control datas form October 2015 to March 2016.
The estimation of carbamazepine measurement uncertainity was calculated
according to ISO21748 guide. Inter laboratory comparison was executed to
estimate bias. Valproic acid levels were determined using the immunoturbidimetric
method on the Roche Cobas Integra 800 analyzer.

Coefficient
variations (CV) calculated from internal quality control analyses were 3,81 and
4,79 at low and high level of internal quality control sera values
respectively. Total allowable error value of valproic acid was 15,51% and was
not higher than desirable TEa% values of CLIA'88.

Carbamazepine is
an anticonvulsant. It works by decreasing nerve impulses that cause seizures
and pain. The therapeutic reference range of carbamazepine is 4-12 mg/L.
Careful clinical monitoring should be performed during the therapy with
carbamazepine. For this purpose, using uncertainty value is a good practice to
interpret of patient result.

Laboratories
should calculate measurement uncertainity and evaluate results according to
spesific criterias. 

Anahtar Kelimeler

EVALUATION OF MEASUREMENT UNCERTAINTY FOR CARBAMAZEPINE

Kaynakça

• Almila ŞENAT, Serpil ERDOGAN, Ceylan BAL, Orhan SEN2, Pervin BARAN, Ozcan EREL
• Yildirim Beyazit University Faculty of Medicine, Department of Public Health, Ankara, Turkey Ataturk Training and Research Hospital, Department of Clinical Biochemistry, Ankara, Turkey