Nephrotoxic Effects of Pesticides

Yıl 2017, Sayı: Issue 1(2) - 3. INTERNATIONAL BIOCIDAL CONGRESS, 3 - 3, 01.02.2017

Tülin Gönültaş Necdet Aytaç Muhsin Akbaba

Öz

Pesticides
are used extensively throughout the world and, in recent years, their use has
increased considerably. Pesticides are responsible for several adverse effects
on human health, and they represent a potential risk to human. Liver and kidney
are firstly most harmed tissues by pesticides, because pesticides are removed
from the body by being metabolized in the liver and kidney main road. A broad range
of pesticides, including organophosphates, organochlorines, carbamates,
pyrethroids and triazine herbicides have been shown to cause renal damage and
dysfunction in animal toxicity studies.The most commonly reported pesticides
implicated in human renal damage are organophosphates, though other pesticides
are known to be nephrotoxic at high levels. Pesticide poisoning case studies,
animal models, and in vitro laboratory research provide evidence for a damaging
effect of both acute and chronic pesticide exposure on renal function Yet, the
impact of long-term pesticide exposure on the human kidney remains unknown.
Evidence suggests that pesticide exposure may harm the kidneys through
oxidative stress and resulting cell damage. Acute tubular necrosis has also
been seen in animal studies of pesticide nephrotoxicity, along with other
evidence of renal damage from pesticide exposure. Commonly observed renal
symptoms in pesticide poisoning include acute tubular necrosis, hematuria, and
proteinuria. Clinically, acute kidney injury is a frequent outcome of pesticide
poisoning among humans, and is associated with subsequent renal disease.
Chronic effects of pesticides on kidney: Albuminurrhea, increased urea
creatinine levels, decreased secretory function Because of potential health
risks, pesticides should be used consciously and under supervision.

 

 

Keywords:
Nephrotoxic,
Pesticides, Poisoning

 

Anahtar Kelimeler

Nephrotoxic Effects of Pesticides

Kaynakça

• Tülin Gönültaş, Necdet Aytaç, Muhsin Akbaba
• Cukurova University Faculty of Medicine, Public Health Department, Adana