Antibiotic resistance by biocide exposure

Yıl 2017, Sayı: Issue 1(2) - 3. INTERNATIONAL BIOCIDAL CONGRESS, 7 - 7, 01.02.2017

Erhan Kaya Ferdi Tanır Muhsin Akbaba

Öz

Antibiotic
resistance is one of the great global challenges in modern medicine. Antibiotic
resistance can occur as a result of resistance mutations or via horizontal gene
transfer. Biocides are crucial to successful infection control and widely used
in hospitals, on farms, in industry and in the home for the control of
microorganisms. Exposure of bacteria to biocides can select for mutants with
decreased biocide susceptibility and these mutants often display a decrease in
susceptibility to various antibiotics, indicating that biocides can act as
drivers of antibiotic resistance under laboratory conditions. Many common
biocides are not detectable in the environment and some, such as triclosan,
have been found in human urine, serum and breast milk. The accumulation of
biocides in the environment also represents a potentially prolonged and
low-level stress that causes decreased biocide susceptibility, which could be
cross-resistant to antibiotics. Mark A.Webber et al found Salmonella enterica
serovar typhimurium mutants highly resistant to both quinolone antibiotics and
the biocide triclosan. Rebecca Wesgate et al showed that exposure to triclosan
(0.0004%) was associated with a high risk of developing resistance and
cross-resistance in Staphylococcus aureus and Escherichia coli. Lu Lv et al The
emerging halogenated nitrogenous disinfection products could raise antibiotic
resistance, even multidrug resistance, in P. aeruginosa PAO1 via mutagenesis,
which was demonstrated by mutation detection. C. soumet et al investigated
adaptive responses of bacterial strains by exposing the strains daily to
increasing sub-inhibitory concentrations of DDAC(didecyl dimethyl ammonium
chloride) for 7 days. Following adaptation to DDAC, reduced susceptibility was
found in Escherichia coli, Listeria monocytogenes and Salmonella strains to BC
(benzalkonium chloride) and a commercial biocide formulation (Galox Horizon)
containing DDAC and glutaraldehyde.

 

 

 

 

Keywords:
antibiotic
resistance, biocide, cross-resistance

Anahtar Kelimeler

Antibiotic resistance by biocide exposure

Kaynakça

• Erhan Kaya, Ferdi Tanır, Muhsin Akbaba Department of Public Health, Faculty of Medicine, Cukurova University, Adana, Turkey