Industrial toxic exposures and cardiotoxicity

Yıl 2017, Volume 2, Issue 1(4), 16 - 16, 01.11.2017

Sevim Sibel Demir Nazan Akçalı Muhsin Akbaba Hayri Sarı

Öz

Human is
constantly interacting with the environment from beginning of life to the day.
This interaction is often negatively affected. Bythe end of the nineteenth
century, human beings had only 50 years of life expectancy at birth. Infant,
child and maternal mortality were high in recent years, mostly due to
bacterial, parasitic diseases. Life expectancy in Turkey is 78 ± 2.7 years as
of 2013-2014. Industrialization and socio-economic development have prolonged
human life and improved the quality of life. Today, the concrete relationship
of many physical and chemical agents with diseases is clearly defined.

Increasing industrial production and end use 'exposure' has shown dramatic
increase especially in the last 50 years. Metals generally affect more than one
organ and system. For that, the "target or critical organ" in metal
poisoning is used for the site of action which is most sensitive to that metal.
Neurotoxicity, nephrotoxicity, gastrointestinal toxicity, fetotoxic and
teratogenic effects, cytotoxicity and immunotoxicity are possible damages.
There are also significant toxic effects on the cardiovascular system.

Lead is effective in inducing endothelial dysfunction and acting as calcium
agonist in cardiovascular system. Clinically, systolic and diastolic blood
pressure rises.It causes ischemic heart disease, left ventricular hypertrophy
and diastolic dysfunction, electrocardiogram changes and cardiac arrhythmias.
Arsenic has a proliferative effect on the vascular system. Clinically, systolic
and diastolic blood pressure rises. Cardiovascular mortality, peripheral atherogenesis,
coronary heart disease, atypical ventricular tachycardia increases. Mercury
causes endothelial dysfunction, inflammation and thrombosis.
Hypertension,coronary artery diseases and myocardial infarction, stroke and
carotid artery diseases, cardiac autonomic nervous system involvement and
cardiac arrhythmia are predisposed.

Further studies using biomarkers to investigate the effect of specific metal on
specific cardiovascular endpoints in this context, which are made in the large
population, analyzed by excising other risk factors, and mechanistic and
pathogenic explaining are needed.

 

 

Keywords:
industry,
cardiotoxicity, metals

Anahtar Kelimeler

Industrial toxic exposures and cardiotoxicity

Kaynakça

• Sevim Sibel Demir1, Nazan Akçalı2, Muhsin Akbaba3, Hayri Sarı1 1Osmaniye Public Health Directorate 2Adana Public Health Directorate 3Çukurova University Faculty of Medicine, Department of Public Health