Heart rate variability in patients with vibration disease complicated with hypertension

Yıl 2017, Volume 2, Issue 1(4), 22 - 22, 01.11.2017

Elena Stanislavovna Khmel Victoriya Vsevolodovna Rodionova Lyudmila Anatolyevna Glinyana2

Öz

Objective:
to study heart rate variability (HRV) in patients with vibration disease (VD)
complicated with hypertension (HT). Materials-Methods: Study involved 60
persons, main group – 25 patients with VD stage II and HT stage II, 2nd degree.
Comparison group consisted of 20 patients with VD stage II without HT. Control
group included 15 almost healthy individuals. During the study patients
received antihypertensive therapy: Amlodipine 5 mg and Lisinopril 5 mg 1 time
per day per os during 14 days. HRV was carried out before and after treatment.
Results: Low frequency/High frequency index (LF/HF) was significantly higher in
the study group before treatment compared with both comparison group and
control group, while the comparison group and control group were not reliably
distinguished among themselves (LF/HF in the study group before treatment - 5
64 [4.87 - 7.56] p<0,05, comparison group - 3.88 [3.61 - 4.58], control
group 2.85 [2.22 - 3.08]; p˃0,05).
Patients of main group had decrease in LF after treatment (LF in the study
group before treatment - 1507 [1105 - 1861], after treatment - 1014 [887 -
1956]; p<0,05). Also patients of main group after treatment had no
significant differences from control group (LF in main group after treatment
1014 [718 - 1084, control group - 1051 [478 - 1385]; p˃0,05).
Patients of main group had reduction of LF/HF index (before treatment - 5.64
[4.87 - 7.56] after treatment - 3.95 [3.94 - 4.64]; p<0,05). Conclusions:
The presence of HT in patients with VD provides additional negative effect on
the HRV, which may cause increasing the risk of mortality. Antihypertensive
therapy which include Lisinopril 5 mg and Amlodipine 5 mg in patients with VD
and HT lead to a decrease in the influence of the sympathetic system and risk
of mortality.

 

Keywords:
heart
rate variability, vibration disease, hypertension

Anahtar Kelimeler

Heart rate variability in patients with vibration disease complicated with hypertension

Kaynakça

• Elena Stanislavovna Khmel1, Victoriya Vsevolodovna Rodionova1, Lyudmila Anatolyevna Glinyana2 1Department of occupational diseases and clinical immunology, State establishment "Dnepropetrovsk medical academy, Ministry of health of Ukraine", Dnepr, Ukraine 2Dnepropetrovsk city multidisciplinary clinical hospital №4, Dnepr, Ukraine