Changes in some electrolyte concentrations in lambs with endotoxemia

Yıl 2023, Cilt: 5 Sayı: 2, 54 - 57, 31.12.2023

Alparslan Coşkun Uğur Aydoğdu Emre Arslanbaş

https://doi.org/10.51755/turkvetj.1395131

Öz

The aim of this study was to reveal the changes in some blood electrolyte levels after LPS infusion in lambs. In the study, 8 Akkaraman breed lambs of both genders, aged 1-3 months, were used. To induce endotoxemia, LPS at a dose of 10 μg/kg was administered intravenously through the jugular vein in 50 ml of 0.9% NaCl over 30 minutes. Clinical examinations were performed and blood samples were taken before LPS administration and at the 2nd, 4th, 6th, 12th and 24th hours after the administration. Sodium (Na+), potassium (K+), chloride (Cl-) and ionized calcium (Ca+2) analyzes of the blood samples were performed on the blood gas device as soon as the blood was taken, without adding any anticoagulant substance. While a significant decrease in K+ level was observed at the 2nd hour after LPS infusion, a significant increase was detected at the 12th hour. While there was no significant change in Na+ and Cl- levels, the Ca+2 level decreased at all hours compared to the beginning, but no statistical difference was determined. As a result, it was evaluated that acute endotoxemia in lambs causes changes in K+ and Ca+2 levels and that monitoring these electrolytes in endotoxemic patients may be useful.

Anahtar Kelimeler

Lamb, endotoxemia, electrolyte

Proje Numarası

V-048

Endotoksemili kuzularda bazı elektrolit konsantrasyolarındaki değişimler

Öz

Bu çalışmanın amacı, kuzularda LPS infüzyonu sonrası bazı kan elektrolit seviyelerindeki değişimlerin ortaya konulmasıydı. Çalışmada her iki cinsiyetten 1-3 aylık yaşta 8 adet Akkaraman ırkı kuzu kullanıldı. Endotokseminin oluşturulması için 10 μg/kg dozda LPS 50 ml’lik %0.9 NaCl içerinde 30 dakikada vena jugularisten intravenöz olarak uygulandı. LPS uygulamasından önce ve uygulama sonrası 2., 4., 6., 12. ve 24. saatlerde klinik muayeneleri yapılarak kan örnekleri alındı. Alınan kan örneklerinden sodyum (Na+), potasyum (K+), klor (Cl-) ve iyonize kalsiyum (Ca+2) analizleri kan gaz cihazında herhangi bir antikoagülan madde katılmaksızın kan alınır alınmaz yapıldı. LPS infüzyonu sonrası 2. saatte K seviyesinde önemli bir düşüş gözlenirken takibinde 12. saatte önemli bir artış tespit edildi. Na+ ve Cl- seviyesinde önemli herhangi bir değişim göze çarpmazken, Ca+2 seviyesi başlangıca göre tüm saatlerde azalmış ancak istatistiksel bir farklılık belirlenmemiştir. Sonuç olarak, kuzularda akut endotokseminin K+ ve Ca+2 seviyelerinde değişikliğe neden olduğu ve endotoksemik hastalarda bu elektrolitlerin izlenmesinin yararlı olabileceği değerlendirildi.

Anahtar Kelimeler

Kuzu, endotoksemi, elektrolit

Destekleyen Kurum

Sivas Cumhuriyet Üniversitesi Bilimsel Araştırma Projeleri Başkanlığı

Proje Numarası

V-048

Kaynakça

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