AQUİLARİA AGALLOCHA ROXB.’ nin TIBBİ KULLANIM ALANLARI ÜZERİNE BİR DERLEME

Öz

Amaç: Aquilaria agallocha farklı kullanım alanları olan, oldukça değerli bir bitki türüdür. Thymelaceceae familyasına ait olan bu bitki ekonomik yönden de oldukça önemlidir. Zamk, aroma verici ya da parfüm gibi sanayi ürünleri olarak kullanılmasının yanı sıra ateş, baş ağrısı, ishal, öksürük gibi hastalıkların tedavisinde de halk ilacı olarak kullanılmaktadır. Bu derlemenin amacı, bu bitkinin tıbbi açıdan hangi hastalıklarda kullanıldığının ortaya konulmasıdır. Yöntem: Geçmişten günümüze bu bitki ile çalışma yapılan bilimsel makale ve derlemeler incelenmiştir. Literatür taraması sonuçları derlenmiştir. Bulgular: Yapılan literatür incelemesinde, birçok farklı alanda deneylerin gerçekleştirildiği ve bitkinin farklı tedavilerde kullanılabileceği gözlemlenmiştir. Sonuç: Aquilaria agallocha binlerce yıldır dünya üzerinde çeşitli amaçlarla geleneksel olarak kullanılmaktadır. Yapılan literatür taramalarında bitkinin tıbbi kullanımının yaygın olduğu görülmüştür. Bu bitkinin daha detaylı farmakolojik ve tıbbi kullanım alanlarının tespiti için, araştırmaların devam etmesi oldukça önemlidir.

Anahtar Kelimeler

• Aquilaria agallocha
• Thymelaceceae
• Tıbbi kullanım
• Bitki

A REVIEW ON THE MEDICAL USES OF AQUILARIA AGALLOCHA ROXB.

Öz

Objective: Aquilaria agallocha is a very valuable plant species with different uses. This plant, which belongs to the Thymelaceceae family, is also very important economically. In addition to being used as industrial products such as glue, flavoring or perfume, it is also used as a folk remedy for the treatment of diseases such as fever, headache, diarrhea and cough. The aim of this review is to revealin which diseases this plant is used medicinally. Methots: Scientific articles and reviews on this plant from past to present were analyzed. The results of the literatüre review were complied. Results: In the literature review, it was observed that experiments were carried out in many different fields and that the plant can be used in different treatments. Conclusion: Aquilaria agallocha has been traditionally used around the World for thousands of years for various purposes. In the literatüre review, it was observed that the medicinal use of the plant is widespread. It is very important to continue research to determine more detailed pharmacological and medicinal uses of this plant.

Anahtar Kelimeler

• Aquilaria agallocha
• Thymelacceceae
• Medical uses
• Plant

Kaynakça

1. 1. Srivastava B, Sharma VC, Sharma H, Pant P, Jadhav AD. Comparative physicochemical, phytochemical and high performance thin layer chromatography evaluation of heart wood and small branches of Aquilaria Agallocha Roxb. International Journal of Ayurveda and Pharma Research. 2016;4(1):1-6.
2. 2. Duke JA. Handbook of phytochemical constituents of GRAS herbs and other economical plants. CRC Press, London. 1992;475-476.
3. 3. Stanisci A. et al. Plant communities on coastal dunes in Lazio (Italy). Annali di Botanica. 2004;4:115-28.
4. 4. Fratkin J. Chinese herbal patent formulas: a practical guide. Shya Publications, 1985.
5. 5. TC Tarım ve Orman Bakanlığı Gıda ve Kontrol Genel Müdürlüğü. Aquilaria agallocha Roxb.’un yaprak kısmının gıdalarda kullanımının güvenilirliğinin değerlendirilmesi hakkında bilimsel görüş. 2022.
6. 6. Wangiyana IGAS. Medicinal usage of Agarwood resin in form of essential oil: a review. Journal Silva Samalas. 2019;2(2):86-90.
7. 7. Chen CH, Yen Kuo TC, Yang MH, Chien TY, Chu MJ, Huang LC, et al. Identification of cucurbitacins and assembly of a draft genom efor Aquilaria agallocha. BMC Genomics. 2014;15(1):578.
8. 8. Alam J, Mujahid M, Badruddeen M, Rahman MA, Akhtar J, Khalid M, et al. An insight of pharmacognostic study and phytopharmacology of Aquilaria agallocha. J Appl Pharma Sci. 2015;5(08):173-181.

9. 9. Tamuli P, Boruah P, Nath SC, Leclercq P. Essential oil of eaglewood tree: a product of pathogenesis. J.Essent. Oil Res. 2005;17:601-604.
10. 10. Kumeta Y, Ito M. Characterization of δ-Guaiene synthases from cultured cells of Aquilaria, responsible for the formation of the sesquiterpenes in Agarwood. Plant Physiology. 2010;154(4):1998–2007.
11. 11. Ahmaed DT, Kulkarni AD. Sesquiterpenes and chromones of Agarwood: a review. Malaysian Journal of Chemistry. 2017;19(1):33–58.
12. 12. Satapathy AK, Gunasekaran G, Sahoo SC, Amit K, Rodriques PV. Corrosion inhibition by Justicia gendarussa plant extract in hydrochloric acid solution. Corrosion Science. 2009;51:2848-2856.
13. 13. Miles AM, Grisham MB. Antioxidant properties of aminosalicylates. Journal Green Pharmacy Information. 1994;234:555-572.
14. 14. Sharma OP, Bhat TK. DPPH antioxidant assay revisited. Food Chem. 2009;113:1202–5.
15. 15. Oraon R, Ansari TM, Shamim A, Bagga P, Ahsan F, Alam M, et al. Pharmacological potentials of Aquilaria agallocha & Borago officinalis: a pragmatic review. World Journal of Pharmaceutical Sciences. 2019;7(4):43–55.
16. 16. Suebsasana S, Pongnaratorn P, Sattayasai J, Arkaravichien T, Tiamkao S, Aromdee C. Analgesic, antipyretic, anti-inflammatory and toxic effects of andrographolide derivatives in experimental animals. Arch Pharm Res. 2009;32:1191–200.
17. 17. Rahman H, Vakati K, Eswaraiah MC. In-vivo and in-vitro antiinflammatory activity of Aquilaria agallocha oil. International Journal of Basis Medical Sciences and Pharmacy. 2012;2(1).
18. 18. Yadav DK, Mudgal V, Agrawal JK, Maurya A, Bawankule UD, Chanotiya S, et al. Molecular docking and ADME studies of natural compounds of Agarwood oil for topical antiinflammatory activity. Curr Comput.-Aided Drug Des. 2013;9:360–370.
19. 19. Chitre T, Bhutada P, Nandakumar K, Somni R, Miniyar P, Mundhana Y, et al. Analgesic and antiinflammatory activity of heartwood of Aquilaria agallocha in laboratory animals, Pharmacologyonline. 2007;1:288-298.
20. 20. Khalil AS, Rahim AA, Taha KK, Abdallah KB. Characterization of methanolic extracts of Agar wood leaves. Journal of Applied And Industrial Sciences. 2013;1(3):78-88.
21. 21. Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain. 1987;30:103-104.
22. 22. Gorski F, Correa CR, Filho VC, Yunes RA, Calixto JB. Potent antinociceptive activity of hydroalcoholic extracts from Phyllanthus corcovadensis. J. Pharm. Pharmacol. 1993;45:1046-1049.
23. 23. Nam O, Zulkifle NL, Tajudin SN, Shaari MR. Antidiabetic activities of Malaysian Agarwood leaves extract. Conference on industry Academia joint initiatives in Biotechnology CIA. 2013;5:7.
24. 24. Aromdee C, Pranakhon R, Pannangpetch P. Antihyperglycemic activity of agarwood leaf extracts in STZ-induced diabetic rats and glucose uptake enhancement activity in rat adipocytes. Songklanakarin J. Sci. Technol. 2011;33(4):405-410.
25. 25. Rahman H, Vakati K, Eswaraiah MC and Dutta AM. Evaluation of hepatoprotective activity of ethanolic extract of Aquilaria agallocha leaves (EEAA) against CCl4 induced hepatic damage in rat. Scholars Journal of Applied Medical Sciences. 2013;1(1):9-12.
26. 26. Chen H, Yang Y, Xue J, Wei J, Zhang Z, Chen H. Comparison of compositions and antimicrobial activities of essential oils from chemically stimulated agarwood, wild agarwood and healthy Aquilaria sinensis (Lour.) Gilg trees. Molecules. 2011;16:4884-4896.
27. 27. Kamonwannasit S, Nantapong N, Kumkrai P, Luecha P, Kupittayanant S, Chudapongse N. Antibacterial activity of Aquilaria crassna leaf extract against Staphylococcus epidermidis by disruption of cell wall. Ann Clin Microbiol Antimicrob. 2013;12(20): 23962360. doi: 10.1186/1476-0711-12-20.
28. 28. Ertaş T, Üstünsoy R, Dinç B. Effects of plant oil from Aquilaria agallocha on lung cancer cell line A549. 32. Ulusal Biyofizik Kongresi (pp.53). İstanbul, Turkey, 2021.
29. 29. Hashim YZ, Phirdaous A, Azura A. Screening of anticancer activity from agarwood essential oil. Pharmacogn. Res. 2014;6:191-194.
30. 30. Ibrahim A, Al-Rawi SS, Majid AMSA, Norulaini N. Separation and fractionation of Aquilaria Malaccensis oil using supercritical fluid extraction and the cytotoxic properties of the extracted oil. Procedia Food Science. 2011;1:1953–1959.
31. 31. Dahham SS, Tabana YM, Iqbal MA, Ahamed MBK, Ezzat MO, Majid ASA, et al. The anticancer, antioxidant and antimicrobial properties of the sesquiterpene β-caryophyllene from the essential oil of Aquilaria crassna. Molecules. 2015;20(7):11808-11829. doi:10.3390/molecules200711808
32. 32. Okugawa H, Ueda R, Matsumoto K, Kawanishi K, Kato A. Effect of agarwood on the central nervous system in mice. Planta Medica. 1993;59:32-36.
33. 33. Okugawa H, Ueda R, Matsumoto K, Kawanishi K, Kato A. Effect of jinkoh-eremol and agarospirol from agarwood on the central nervous system in mice. Planta Med. 1996;62(1):2-6.
34. 34. Takemoto H, Ito M, Shiraki T, Yagura T, Honda G. Sedative effects of vapour inhalation of agar wood oil and spikenard extract and identification of their active components. Journal of Natural Medical Science. 2008;62:41–46.
35. 35. Alla T, Handral M, Nandakumar K, Venkatrao N, Shalam S, Shantakumar SM. Anxiolytic and anticonvulsant activity of alcoholic extract of heartwood of Aquilaria agallocharoxb (Thymelaeceae) in mice. Pharmacologyonline. 2007;1:564-572.
36. 36. Kim YC, Lee EH, Lee YM, Kim KH, Song B, Lee EJ, et al. Effect of the aqueous extract of Aquilaria agallocha stems on the immediate hypersensitivity reactions. Journal of Ethnopharmacology. 1997;1:31-38.
37. 37. Hara H, Ise Y, Morimoto N, Shimazawa M, Ichihashi K, Ohyama M, et al. Laxative effect of agar wood leaves and its mechanism. Scholars Journal of Applied Medical Sciences. 2008;1:335-345.
38. 38. Liu Y, Wang S, Zhou Y, Zhang Q. Effect of agarwood extracts produced by the whole-tree agarwood-inducing technique on gastrointestinal motility and gastric ulcer. J. Int. Pharm. Res. 2016;43:1076-4081.
39. 39. Kakino M, Tazawa S, Maruyama H, Tsuruma K, Araki Y, Shimazawa M, et al. Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complement. Altern. Med. 2010;10.
40. 40. Syed NIH, Mahmood Q, Ahmad M, Akhtar MS. Inotropic and chronotropic effects of methanol extract of Aquilaria agallocha on rabbit heart. Bangladesh J Pharmacol. 2013;8:311-316.