Association of Heat Shock Proteins with Cancer

Yıl 2023, Cilt: 1 Sayı: 1, 60 - 66, 13.10.2023

Harika Topal Önal

Öz

Aim: Heat shock proteins (HSPs) are proteins that assist cells in activating defense mechanisms against various stress factors. This review discusses the relationship between heat shock proteins and cancer. By shedding light on the potential effects of heat shock proteins in the context of cancer biology, it provides an important perspective for future treatment strategies and approaches to combat cancer.

Materials and Methods: This compilation is based on a review of recent studies investigating the effects of heat shock proteins on cancer formation and treatment processes.

Results: Recent research indicates that these proteins can be found at higher levels in cancer cells than in normal cells and may potentially play a role in cancer development, progression, and the acquisition of resistance to treatment. Furthermore, it is suggested that HSPs may help tumors evade the immune system by preventing the recognition of cancer cells. Additionally, heat shock proteins are proposed to be effective in the development of resistance to cancer therapies.
Conclusion: Future studies in this field may enable the development of more effective strategies for combating cancer.

Anahtar Kelimeler

heat shock proteins, cancer, apoptosis, cancer cell resistance

Isı Şoku Proteinlerinin Kanser ile ilişkisi

Öz

mekanizmalarını aktive etmelerine yardımcı olan proteinlerdir. Bu derleme, ısı şok proteinlerinin kanserle ilişkisini ele almaktadır. Isı şok proteinlerinin kanser biyolojisi içindeki potansiyel etkilerini aydınlatarak, gelecekteki tedavi stratejileri ve kanserle mücadele yaklaşımları için önemli bir perspektif sunmaktadır.
Materyal-Metot: Isı şok proteinlerinin kanser oluşumunda ve tedavi sürecindeki etkilerini araştıran güncel çalışmaların derlenmesi ile oluşmuştur.
Bulgular Son yapılan araştırmalar, bu proteinlerin kanser hücrelerinde normalden daha yüksek düzeylerde bulunabileceğini ve kanserin gelişiminde, yayılmasında ve tedaviye direnç kazanmasında potansiyel rol oynayabileceğini göstermektedir. HSP' lerin ayrıca, kanser hücrelerinin bağışıklık sistemince fark edilmesini engelleyerek tümörlerin bağışıklık savunma mekanizmalarından kaçmasına yardımcı olabileceği düşünülmektedir. Bunun yanı sıra, ısı şok proteinlerinin kanser tedavilerine karşı direnç gelişiminde etkili olabileceği de öne sürülmektedir.
Sonuç: Bu alanda yapılacak olan ilerideki çalışmalar, kanserle mücadelede daha etkili stratejilerin geliştirilmesine olanak tanıyabilir.

Anahtar Kelimeler

Isı şok proteinleri, kanser, apoptoz, kanser hücre direnci

Kaynakça

• 1. Wu J, Liu T, Rios Z, Mei Q, Lin X, Cao S. Heat Shock Proteins and Cancer. Trends Pharmacol Sci. 2017;38(3):226-256. doi:10.1016/j.tips.2016.11.009
• 2. Alimardan Z, Abbasi M, Hasanzadeh F, Aghaei M, Khodarahmi G, Kashfi K. Heat shock proteins and cancer: The FoxM1 connection. Biochem Pharmacol. 2023;211:115505. doi:10.1016/j.bcp.2023.115505.
• 3. Albakova Z. Heat Shock Proteins in Cancer Immunotherapy. Handbook of Cancer and Immunology. 2023; 1-15.
• 4. Li Z, Srivastava P. Heat-shock proteins. Curr Protoc Immunol. 2004;Appendix 1:. doi:10.1002/0471142735.ima01ts58
• 5. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006;31(3):164-172. doi:10.1016/j.tibs.2006.01.006
• 6. Zhou G, Pu Y, Zhao K, Chen Y, Zhang G. Heat Shock Proteins in Non-Small-Cell Lung Cancer—Functional Mechanism. Frontiers in Bioscience-Landmark, 2023;28(3), 56.
• 7. Kiang JG, Tsokos GC. Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology. Pharmacol Ther. 1998;80(2):183-201. doi:10.1016/s0163-7258(98)00028-x
• 8. Calderwood SK, Ciocca DR. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia. 2008;24(1):31-39. doi:10.1080/02656730701858305
• 9. Li G, Wu S, Chen W, et al. Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer. Small Methods. 2023;7(2):e2201313. doi:10.1002/smtd.202201313
• 10. Huffman OG, Chau DB, Dinicu AI, DeBernardo R, Reizes O. Mechanistic Insights on Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. Cancers (Basel). 2023;15(5):1402. Published 2023 Feb 22. doi:10.3390/cancers15051402 11. Qiu C, Zhang W, Zhou Y, Cui H, Xing Y, Yu F, Wang R. Highly sensitive surface-enhanced Raman scattering (SERS) imaging for phenotypic diagnosis and therapeutic evaluation of breast cancer. Chemical Engineering Journal. 2023; 459, 141502.
• 12. Pratt WB, Toft DO. Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70- Based Chaperone Machinery. Exp Biol Med 2003; 228(2): 111-33.
• 13. Schlesinger MJ. How the cell copes with stress and the function of heat shock proteins. Pediatr Res 1994; 36: 1–6.
• 14. Hut HMJ, Kampinga HM, Sibon OCM. Hsp70 protects mitotic cells against heatinduced centrosome damage and division abnormalities. Mol Biol Cell 2005; 16: 3776–85.
• 15. Guo X, Zhang M, Qin J, Li Z, Rankl C, Jiang X, Tang J. Revealing the Effect of Photothermal Therapy on Human Breast Cancer Cells: A Combined Study from Mechanical Properties to Membrane HSP70. ACS Applied Materials & Interfaces, 2023; 15(18), 21965-21973.
• 16. Nylandsted J, Gyrd-Hansen M, Danielewicz A, et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med. 2004;200(4):425-435. doi:10.1084/jem.20040531
• 17. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones. 2005;10(2):86-103. doi:10.1379/csc-99r.1
• 18. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70. doi:10.1016/s0092-8674(00)81683-9
• 19. Sherman M, Multhoff G. Heat shock proteins in cancer. Ann N Y Acad Sci. 2007;1113:192-201. doi:10.1196/annals.1391.030
• 20. Sen T, Sen N, Brait M, et al. DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation. Cancer Res. 2011;71(3):1167-1176. doi:10.1158/0008-5472.CAN-10-1481
• 21. Kleinjung T, Arndt O, Feldmann HJ, Bockmühl U, Gehrmann M, Zilch T, ... & Multhoff G. Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy—a target for natural killer (NK) cells. International Journal of Radiation Oncology* Biology* Physics. 2003;57(3):820-826.
• 22. Qiao P, Tian Z. Atractylenolide I inhibits EMT and enhances the antitumor effect of cabozantinib in prostate cancer via targeting Hsp27. Front Oncol. 2023;12:1084884. Published 2023 Jan 6. doi:10.3389/fonc.2022.1084884
• 23. Jego G, Hazoumé A, Seigneuric R, Garrido C. Targeting heat shock proteins in cancer. Cancer Lett. 2013;332(2):275-285. doi:10.1016/j.canlet.2010.10.014 24. Vidyasagar A, Wilson NA, Djamali A. Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target. Fibrogenesis Tissue Repair. 2012;5(1):7. Published 2012 May 7. doi:10.1186/1755-1536-5-7
• 25. Seigneuric R, Mjahed H, Gobbo J, et al. Heat shock proteins as danger signals for cancer detection. Front Oncol. 2011;1:37. Published 2011 Nov 10. doi:10.3389/fonc.2011.00037
• 26. Moran L, Mirault ME, Arrigo AP, Goldschmidt-Clermont M, Tissières A. Heat shock of Drosophila melanogaster induces the synthesis of new messenger RNAs and proteins. Philos Trans R Soc Lond B Biol Sci. 1978;283(997):391-406. doi:10.1098/rstb.1978.0044
• 27. Ritossa F, A new puffing pattern induced by temperature shock and DNP in drosophila, Cell. Mol. Life Sci. 1962;(18):571–573
• 28. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. J Biol Chem. 1999;274(34):24270-24279. doi:10.1074/jbc.274.34.24270.
• 29. Tsutsumi-Ishii Y, Tadokoro K, Hanaoka F, Tsuchida N. Response of heat shock element within the human HSP70 promoter to mutated p53 genes. Cell Growth Differ. 1995;6(1):1-8.
• 30. Khaleque MA, Bharti A, Sawyer D, et al. Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene. 2005;24(43):6564-6573. doi:10.1038/sj.onc.1208798.
• 31. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet. 1988;22:631-677. doi:10.1146/annurev.ge.22.120188.003215.
• 32. Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene. 2004;23(16):2907-2918.
• 33. Roufayel R, Kadry S. Molecular chaperone HSP70 and key regulators of apoptosis-a review. Curr Mol Med. 2019;19(5):315-325.
• 34. Wang F, Dezfouli AB, Khosravi M, Sievert W, Stangl S, Schwab M, et al. Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70. Cell Death Discovery. 2023;9(1):286.
• 35. Tolomeo D, Traversa D, Venuto S, Ebbesen KK, García Rodríguez JL, Tamma G, et al. circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype‐definition in small cell lung cancer. Genes Chromosomes Cancer. 2023.
• 36. Miller P, Akama-Garren EH, Owen RP, Demetriou C, Carroll TM, Slee E, et al. p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer. Cell Death Differ. 2023:1-17.
• 37. Ferbeyre G, Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GH, et al. Oncogenic ras and p53 Cooperate to Induce Cellular Senescence. Mol Cell Biol. 2002;22(10):3497–508.
• 38. Trost TM, Lausch EU, Fees SA. Premature Senescence Is a Primary Fail-safe Mechanism of ERBB2-Driven Tumorigenesis in Breast Carcinoma. Cells Cancer Res. 2005;65:840-49.
• 39. Nilsson JA, Cleveland JL. Myc pathways provoking cell suicide and cancer. Oncogene. 2003;22(56):9007-9021.
• 40. Vita M, Henriksson M. The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol. 2006;16(4):318-330.
• 41. Zhao K, Zhou G, Liu Y, Zhang J, Chen Y, Liu L, et al. HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances. Biomolecules. 2023;13(4):601.
• 42. Aguilar A, Wang S. Therapeutic strategies to activate p53. Pharmaceuticals. 2022;16(1):24.
• 43. Ito A, Honda H, Kobayashi T. Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of “heat-controlled necrosis” with heat shock protein expression. Cancer Immunology, Immunotherapy. 2006;55:320-328.