Asprosinin Obeziteyle İlişkisi ve Beslenmenin Asprosin Seviyelerine Etkisi

Yıl 2024, Cilt: 7 Sayı: 3, 83 - 99, 28.12.2024

Aziz Kılınç

https://doi.org/10.51536/tusbad.1534459

Öz

Obezite artan prevalansı ile dünyada yaygın bir halk sağlığı problemi haline gelmiştir. Obezite prevalansının düşürülmesine yönelik tedavi stratejilerine artan bir ilgi vardır. Asprosin esas olarak beyaz adipoz dokuda üretilip salgılanan ve iştahı uyaran bir hormonal adipokin türüdür. Obezitede adipokinlerin üretim ve salınım profilinde dengesizlikler söz konusu olabilir. Adipoz dokudan artmış asprosin ekspresyonunun obezite için bağımsız bir risk faktörü olduğu belirtilmektedir. Artmış asprosin ekspresyonu aynı zamanda endoplazmik retikulum stres, inflamasyon ve insülin direnci ile ilişkilendirilmiştir. Asprosin üretimi ve salınımı, beslenme durumuyla koordineli olarak sirkadiyen ritmiklik gösterir. Beslenme ve diyet müdahalelerinin asprosin düzeyine etkisine ilişkin klinik çalışmalar yetersizdir. Bu derleme makalede bazı besin ögelerinin asprosin düzeyleri ile ilişkisi incelenecektir.

Anahtar Kelimeler

Adipokinler, Beslenme tedavisi, Egzersiz, Obezite

The Relationship Between Asprosin and Obesity and the Effect of Nutrition on Asprosin Levels

Öz

Obesity has become a common public health problem in the world with its increasing prevalence. There is increasing interest in treatment strategies to reduce the prevalence of obesity. Asprosin is a type of hormonal adipokine that is produced and secreted mainly in white adipose tissue and stimulates appetite. In obesity, there may be imbalances in the production and release profile of adipokines. It is stated that increased asprosin expression from adipose tissue is an independent risk factor for obesity. Increased asprosin expression has also been associated with endoplasmic reticulum stress, inflammation and insulin resistance. Asprosin production and release exhibit circadian rhythmicity in coordination with nutritional status. Clinical studies on the effect of nutrition and dietary interventions on asprosin levels are insufficient. In this review article, the relationship between some nutrients and asprosin levels will be examined.

Anahtar Kelimeler

Adipokines, Exercise, Nutrition therapy, Obesity

Kaynakça

• Yao T, Song C, Yu Y, Cheng Y, Lu H, Li J, et al. Diet and exercise interventions reduce serum asprosin and the corresponding hypothalamic- pituitary-gonad-axis dysfunction in obese men. Front Physiol. 2022;13:896735.
• Huang R, Song C, Li T, Yu C, Yao T, Gao H, et al. A cross-sectional comparative study on the effects of body mass index and exercise/sedentary on serum asprosin in male college students. PLoS One. 2022;17(4):e0265645.
• Farrag M, Ait Eldjoudi D, González-Rodríguez M, Cordero-Barreal A, Ruiz-Fernández C, Capuozzo M, et al. Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects. Front Endocrinol (Lausanne). 2022;13:1101091.
• Gokdemir GS, Gokdemir MT, Tasdemir E, et al. Importance of curcumin effect and asprosin level on glucose metabolism in diabetic rats. Med Science. 2023;12:167-74.
• Ugur K, Aydin S. Saliva and Blood Asprosin Hormone Concentration Associated with Obesity. Int J Endocrinol. 2019;2019:2521096.
• Mishra I, Duerrschmid C, Ku Z, He Y, Wie W, Silva ES, et al. Asprosin-neutralizing antibodies as a treatment for metabolic syndrome. eLife. 2021;10:e63784.
• Basu B, Jain M, Chopra AR. Caudamins, a new subclass of protein hormones. Trends Endocrinol Metab. 2021;32(12):1007-14.
• Ugur K, Erman F, Turkoglu S, Aydin Y, Aksoy A, Lale A, et al. Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome. Eur Rev Med Pharmacol Sci. 2022;26(6):2124-33.
• Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, et al. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017;23(12):1444-53.
• Wang CY, Lin TA, Liu KH, Liao CH, Liu YY, Wu VC, et al. Serum asprosin levels and bariatric surgery outcomes in obese adults. Int J Obes (Lond). 2019;43(5):1019-25.
• Shabir K, Brown JE, Afzal I, Gharanei S, Weickert MO, Barber TM, et al. Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence. Cytokine Growth Factor Rev. 2021;60:120-32.
• Zhang Z, Zhu L, Wang Z, Hua N, Hu S, Chen Y. Can the new adipokine asprosin be a metabolic troublemaker for cardiovascular diseases? A state-of-the-art review. Prog Lipid Res. 2023;91:101240.
• Hu Y, Xu Y, Zheng Y, Kang Q, Lou Z, Liu Q, et al. Increased plasma asprosin levels in patients with drug-naive anorexia nervosa. Eat Weight Disord. 2021;26(1):313-21.
• Corica D, Pepe G, Aversa T, Currò M, Curatola S, Li Pomi A, et al. Meal-Related Asprosin Serum Levels Are Affected by Insulin Resistance and Impaired Fasting Glucose in Children With Obesity. Front Endocrinol (Lausanne). 2021;12:805700.
• Long W, Xie X, Du C, Zhao Y, Zhang C, Zhan D, et al. Decreased Circulating Levels of Asprosin in Obese Children. Horm Res Paediatr. 2019;91(4):271-7.
• Deng X, Zhao L, Guo C, Yang L, Wang D, Li Y, et al. Higher Serum Asprosin Level is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes. Diabetes Metab Syndr Obes. 2020;13:4341-51.
• Ertuna GN, Sahiner ES, Yilmaz FM, Ates I. The role of irisin and asprosin level in the pathophysiology of prediabetes. Diabetes Res Clin Pract. 2023;199:110642.
• Nedeva IS, Assyov Y, Karamfilova V, Vodenicharov V, Gerganova A, Hristova J, et al. Circulating Asprosin Concentrations in Patients with Obesity and Carbohydrate Disturbances. Horm Metab Res. 2023;55(4):284-9.
• Dina A.M. Al-Khafajy , Maysaa J. Majeed , Omar F. Al-Azzawi ; Ayad Ismael Khaleel. (2021). Asprosin Role for Obese Male Patients with Diabetic Mellitus Type II. Medico Legal Update, 21(1), 1345–1349. https://doi.org/10.37506/mlu.v21i1.2507.
• Hoffmann T, Morcos YAT, Janoschek R, Turnwald EM, Gerken A, Müller A, et al. Correlation of metabolic characteristics with maternal, fetal and placental asprosin in human pregnancy. Endocr Connect. 2022;11(3).
• Al-Daghri NM, Alokeel RMI, Alamro A, Ansari MGA, Hussain SD, Amer OE, et al. Serum asprosin levels are associated with obesity and insulin resistance in Arab adults. Journal of King Saud University - Science. 2022;34(1):101690.
• Wang M, Yin C, Wang L, Liu Y, Li H, Li M, et al. Serum Asprosin Concentrations Are Increased and Associated with Insulin Resistance in Children with Obesity. Ann Nutr Metab. 2019;75(4):205-12.
• Zhong L, Long Y, Wang S, Lian R, Deng L, Ye Z, et al. Continuous elevation of plasma asprosin in pregnant women complicated with gestational diabetes mellitus: A nested case-control study. Placenta. 2020;93:17-22.
• Cui J, Wang Z, Yin J, Li M, Wu Q, Liu M, et al. The relationship between 25-hydroxy vitamin D and serum asprosin in patients with type 2 diabetes in the community. Frontiers in endocrinology. 2024;15:1409156.
• Koyuncu S, Sipahioglu H, Uysal C, Karakukcu C. Correlation of Serum Asprosin Levels With Normalized Protein Catabolic Rate in Patients Receiving Peritoneal Dialysis Treatment. Cureus. 2023;15(5):e38441.
• Jowik K, Dmitrzak-Węglarz M, Pytlińska N, Jasińska-Mikołajczyk A, Słopień A, & Tyszkiewicz-Nwafor M. Apelin-13 and Asprosin in Adolescents with Anorexia Nervosa and Their Association with Psychometric and Metabolic Variables. Nutrients. 2022;14(19): 4022.
• Du C, Wang C, Guan X, Li J, Du X, Xu Z, et al. Asprosin is associated with anorexia and body fat mass in cancer patients. Support Care Cancer. 2021;29(3):1369-75.
• Mazur-Bialy AI. Asprosin-A Fasting-Induced, Glucogenic, and Orexigenic Adipokine as a New Promising Player. Will It Be a New Factor in the Treatment of Obesity, Diabetes, or Infertility? A Review of the Literature. Nutrients. 2021;13(2).
• Nam H, Hong SS, Jung KH, Kang S, Park MS, Kang S, et al. A Serum Marker for Early Pancreatic Cancer With a Possible Link to Diabetes. J Natl Cancer Inst. 2022;114(2):228-34.
• Sathoria P, Chuphal B, Rai U, Roy B. Asprosin regulates male reproduction in teleosts: an in vitro study in Channa punctata. The journal of endocrinology. 2024;263(3):e240146.
• Morcos YAT, Lütke S, Tenbieg A, Hanisch F-G, Pryymachuk G, Piekarek N, et al. Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin. Scientific Reports. 2022;12(1):1340.
• Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - A Comparison Between Sexes. Front Physiol. 2018;9:1782.
• Sünnetçi Silistre E, Hatipoğl HU. Increased serum circulating asprosin levels in children with obesity. Pediatr Int. 2020;62(4):467-76.
• Turk A, Kuloglu T, Karadag A, Ozcan Metin T. Effects of Vitamin D on Asprosin Immunoreactivity Against Cyclophosphamide-Induced Liver Injury in Rats. Cureus. 2023;15(10):e46711.
• Ceylan H, Saygın Ö, Özel Türkcü Ü. Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men. Chronobiol Int. 2020;37(8):1252-68.
• Çakır S, Demirtaş Y. Effects of High Calorie Dietary Nutrition and Exercise on Energy Metabolism Parameters in Obese Wistar Albino Rats. Cukurova Medical Journal. 2023; 48(4):1388-95.
• Suder A, Makiel K, Targosz A, Kosowski P, Malina RM. Effects of exercise and dietary interventions on asprosin, leptin, and lipid metabolism in males with abdominal obesity, a randomized controlled trial. Scientific reports. 2024;14(1):28109.
• Shemirani F, Djafarian K, Fotouhi A, Azadbakht L, Rezaei N, Chamari M, et al. Effect of Paleolithic-based low-carbohydrate vs. moderate-carbohydrate diets with portion-control and calorie-counting on CTRP6, asprosin and metabolic markers in adults with metabolic syndrome: A randomized clinical trial. Clin Nutr ESPEN. 2022;48:87-98.
• Yilmaz A, Toraman MN, Mataraci Karakas S, Ozden S, Pinarbas E, Mercantepe T. Effect of white tea on leptin and asprosin levels in rats feeding a high-fat diet. Life. 2024;14(12):1548.
• Yang Z, Jiang J, Huang J, Zhao Y, Luo X, Song L. [Effect of high-fat diet and exercise on asprosin and CTRP6 expression in subcutaneous and retroperitoneal adipose tissues in rats during mid-gestation]. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(10):1406-14.
• Gkouskou KG, Georgiopoulos G, Vlastos I, Lazou E, Chaniotis D, Papaioannou TG, et al. CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study. Int J Obes (Lond). 2022;46(1):162-8.
• Bengin E, Kırtepe A, Çınar V, Akbulut T, Russo L, Aydemir İ, et al. Leptin, ghrelin, irisin, asprosin and subfatin changes in obese women: effects of exercise and different nutrition types. Medicina. 2024;60(7):1118.
• Mohammed , S. A. ., & Allwsh , T. A. . (2022). Study interplay between Asprosin with Vitamin D in metabolic syndrome. Journal of Contemporary Medical Sciences, 8(6), 395–399. https://doi.org/10.22317/jcms.v8i6.1300.
• Naghizadeh M, Karajibani M, Fanaei H, Montazerifar F, Dashipour A. Effect of synbiotic supplementation on asprosin level in high fat diet-induced metabolic disorder in pregnant rats. Mediterranean Journal of Nutrition and Metabolism. 2022;15:81-90.