Yıl 2017, Cilt 4 , Sayı 3, Sayfalar 275 - 280 2017-10-31

The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats
The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats

Ferda ARI [1] , Egemen DERE [2] , Hakan TOSUNOĞLU [3] , İmren ALİOĞLU [4]


Fenarimol and methyl parathion are pesticides that have been used in agriculture for several years. These pesticides have significant effects on environmental and human health. Therefore, we investigated the effects of methyl parathion and fenarimol on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The glucose 6-phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway and it is important in detoxifying reactions by NADPH generated. In this study, wistar albino rats administrated with methyl parathion (7 mg kg–1) and fenarimol (200 mg kg−1) by intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose 6-phosphate dehydrogenase enzyme activity was assayed in liver, kidney, brain, and small intestine in male and female rats. The exposure of fenarimol and methyl parathion caused increase of glucose 6-phosphate dehydrogenase enzyme activity in rat tissues, especially at last periods. We suggest that this increment of enzyme activity may be the reason of toxic effects of fenarimol and methyl parathion.

Fenarimol and methyl parathion are pesticides that have been used in agriculture for several years. These pesticides have significant effects on environmental and human health. Therefore, we investigated the effects of methyl parathion and fenarimol on glucose 6-phosphate dehydrogenase (EC 1.1.1.49) enzyme activity in rats. The glucose 6-phosphate dehydrogenase is the first enzyme of the pentose phosphate pathway and it’s important in detoxifying reactions by NADPH generated. In this study, wistar rats administrated with methyl parathion (7 mg.kg–1) and fenarimol (200 mg.kg−1) by intraperitoneally for different periods (2, 4, 8, 16, 32, 64, and 72 h). The glucose 6-phosphate dehydrogenase enzyme activity was assayed in liver, kidney, brain and small intestine in male and female rats. The exposure of fenarimol and methyl parathion caused increase of glucose 6-phosphate dehydrogenase enzyme activity in rat tissues especially last periods. We suggest that this increment of enzyme activity may be reason of toxic effects of fenarimol and methyl parathion.

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Konular Fen
Yayımlanma Tarihi Ekim 2017
Bölüm Araştırma Makalesi / Research Article
Yazarlar

Orcid: orcid.org/0000-0002-6729-7908
Yazar: Ferda ARI
Kurum: Uludag University, Faculty of Science and Art, Department of Biology
Ülke: Turkey


Orcid: orcid.org/0000-0001-9572-1051
Yazar: Egemen DERE
Kurum: Uludag University, Faculty of Science and Art, Department of Biology
Ülke: Turkey


Orcid: orcid.org/0000-0001-7878-3373
Yazar: Hakan TOSUNOĞLU
Kurum: Uludag University, Faculty of Science and Art, Department of Biology
Ülke: Turkey


Orcid: orcid.org/0000-0003-0687-9362
Yazar: İmren ALİOĞLU
Kurum: Uludag University, Faculty of Science and Art, Department of Biology
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Ekim 2017

Bibtex @araştırma makalesi { tutad310371, journal = {Türkiye Tarımsal Araştırmalar Dergisi}, issn = {2148-2306}, eissn = {2528-858X}, address = {}, publisher = {Siirt Üniversitesi}, year = {2017}, volume = {4}, pages = {275 - 280}, doi = {10.19159/tutad.310371}, title = {The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats}, key = {cite}, author = {ARI, Ferda and DERE, Egemen and TOSUNOĞLU, Hakan and ALİOĞLU, İmren} }
APA ARI, F , DERE, E , TOSUNOĞLU, H , ALİOĞLU, İ . (2017). The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats. Türkiye Tarımsal Araştırmalar Dergisi , 4 (3) , 275-280 . DOI: 10.19159/tutad.310371
MLA ARI, F , DERE, E , TOSUNOĞLU, H , ALİOĞLU, İ . "The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats". Türkiye Tarımsal Araştırmalar Dergisi 4 (2017 ): 275-280 <https://dergipark.org.tr/tr/pub/tutad/issue/31029/310371>
Chicago ARI, F , DERE, E , TOSUNOĞLU, H , ALİOĞLU, İ . "The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats". Türkiye Tarımsal Araştırmalar Dergisi 4 (2017 ): 275-280
RIS TY - JOUR T1 - The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats AU - Ferda ARI , Egemen DERE , Hakan TOSUNOĞLU , İmren ALİOĞLU Y1 - 2017 PY - 2017 N1 - doi: 10.19159/tutad.310371 DO - 10.19159/tutad.310371 T2 - Türkiye Tarımsal Araştırmalar Dergisi JF - Journal JO - JOR SP - 275 EP - 280 VL - 4 IS - 3 SN - 2148-2306-2528-858X M3 - doi: 10.19159/tutad.310371 UR - https://doi.org/10.19159/tutad.310371 Y2 - 2017 ER -
EndNote %0 Türkiye Tarımsal Araştırmalar Dergisi The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats %A Ferda ARI , Egemen DERE , Hakan TOSUNOĞLU , İmren ALİOĞLU %T The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats %D 2017 %J Türkiye Tarımsal Araştırmalar Dergisi %P 2148-2306-2528-858X %V 4 %N 3 %R doi: 10.19159/tutad.310371 %U 10.19159/tutad.310371
ISNAD ARI, Ferda , DERE, Egemen , TOSUNOĞLU, Hakan , ALİOĞLU, İmren . "The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats". Türkiye Tarımsal Araştırmalar Dergisi 4 / 3 (Ekim 2017): 275-280 . https://doi.org/10.19159/tutad.310371
AMA ARI F , DERE E , TOSUNOĞLU H , ALİOĞLU İ . The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats. TÜTAD. 2017; 4(3): 275-280.
Vancouver ARI F , DERE E , TOSUNOĞLU H , ALİOĞLU İ . The Effects of Fenarimol and Methyl Parathion on Glucose 6-Phosphate Dehydrogenase Enzyme Activity in Rats. Türkiye Tarımsal Araştırmalar Dergisi. 2017; 4(3): 280-275.