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THE METHOD OF LINES FOR THE NUMERICAL SOLUTION OF A MATHEMATICAL MODEL IN THE INITIATION OF ANGIOGENESIS

Yıl 2013, Cilt: 3 Sayı: 2, 182 - 197, 01.12.2013

Öz

In this paper we present the method of lines to obtain the numerical solution of a mathematical model for the roles of endothelial, pericyte and macrophage cells in the initiation of tumor angiogenesis. This method is an approach to the numerical solution of partial differential equations that involve a time variable t and a space variable x. We provide computer programs written in Matlab. Also, the stability analysis of the solutions is given, and the figures for endothelial, pericyte and macrophage cell movements in the capillary are presented for large times

Kaynakça

  • Ahmad, I. and Berzins, M., (2001), MOL solvers for hyperbolic PDEs with source terms, Math. Comput. Simulat., 56 (2), 115-125.
  • Erdem, A. and Pamuk, S., (2007), The method of lines for the numerical solution of a mathematical model for capillary formation: The role of tumor angiogenic factor in the extra-cellular matrix, Appl. Math. Comput., 186, 891-897.
  • Korn, G.A., (1999), Interactive solution of partial differential equations by the Method-of-lines, Math. Comput. Simulat., 49 (1-2), 129-138.
  • Levine, H.A., Sleeman, B.D. and Nilsen-Hamilton, M., (2000), A mathematical model for the roles of pericytes and macrophages in the initiation of angiogenesis. I.The role of protease inhibitors in preventing angiogenesis, Math. Biosc., 168, 77-115.
  • Mikhail, M.N., (1987), On the validity and stability of the method of lines for the solution of partial differential equations, Appl. Math. Comput., 22 (2-3), 89-98.
  • Pamuk, S. and Erdem, A., (2007), The method of lines for the numerical solution of a mathematical model for capillary formation: The role of endothelial cells in the capillary, Appl. Math. Comput., 186, 831-835.
  • Pamuk, S., (2003), Qualitative analysis of a mathematical model for capillary formation in tumor angiogenesis, Math. Models and Methods Apll. Sci., 13 (1), 19-33.
  • Schor, A.M., CanŞeld, A.E., Sutton,A.B., Allen,T.D., Sloan,P., Schor, S.L., Steiner,R., Weisz, P.B. and Langer,R., (1992), The behavior of pericytes in vitro: relevance to angiogenesis and differentiation, Angiogenesis: Key Principles-Science-Technology-Medicine, Birkhauser, Basel.
  • Shakeri, F. and Dehghan, M., (2008), The method of lines for solution of the one-dimensional wave equation subject to an integral conservation condition, Comput. and Math. with Appl., 56, 2175-2188. [10] Sharaf, A.A. and Bakodah, H.O., (2005), A good spatial discretisation in the method of lines, Appl. Math. Comput., 171 (2), 1253-1263.
  • Younes,A., Konz,M., Fahs, M., Zidane, A. and Huggenberger, P., (2011), Modelling variable den- sity flow problems in heterogeneous porous media using the method of lines and advanced spatial discretization methods, Math. Comput. Simulat., 81, 2346-2355.
  • Teschl, G., (1991), Ordinary Differential Equations and Dynamical Systems, American Mathematical Society.
Yıl 2013, Cilt: 3 Sayı: 2, 182 - 197, 01.12.2013

Öz

Kaynakça

  • Ahmad, I. and Berzins, M., (2001), MOL solvers for hyperbolic PDEs with source terms, Math. Comput. Simulat., 56 (2), 115-125.
  • Erdem, A. and Pamuk, S., (2007), The method of lines for the numerical solution of a mathematical model for capillary formation: The role of tumor angiogenic factor in the extra-cellular matrix, Appl. Math. Comput., 186, 891-897.
  • Korn, G.A., (1999), Interactive solution of partial differential equations by the Method-of-lines, Math. Comput. Simulat., 49 (1-2), 129-138.
  • Levine, H.A., Sleeman, B.D. and Nilsen-Hamilton, M., (2000), A mathematical model for the roles of pericytes and macrophages in the initiation of angiogenesis. I.The role of protease inhibitors in preventing angiogenesis, Math. Biosc., 168, 77-115.
  • Mikhail, M.N., (1987), On the validity and stability of the method of lines for the solution of partial differential equations, Appl. Math. Comput., 22 (2-3), 89-98.
  • Pamuk, S. and Erdem, A., (2007), The method of lines for the numerical solution of a mathematical model for capillary formation: The role of endothelial cells in the capillary, Appl. Math. Comput., 186, 831-835.
  • Pamuk, S., (2003), Qualitative analysis of a mathematical model for capillary formation in tumor angiogenesis, Math. Models and Methods Apll. Sci., 13 (1), 19-33.
  • Schor, A.M., CanŞeld, A.E., Sutton,A.B., Allen,T.D., Sloan,P., Schor, S.L., Steiner,R., Weisz, P.B. and Langer,R., (1992), The behavior of pericytes in vitro: relevance to angiogenesis and differentiation, Angiogenesis: Key Principles-Science-Technology-Medicine, Birkhauser, Basel.
  • Shakeri, F. and Dehghan, M., (2008), The method of lines for solution of the one-dimensional wave equation subject to an integral conservation condition, Comput. and Math. with Appl., 56, 2175-2188. [10] Sharaf, A.A. and Bakodah, H.O., (2005), A good spatial discretisation in the method of lines, Appl. Math. Comput., 171 (2), 1253-1263.
  • Younes,A., Konz,M., Fahs, M., Zidane, A. and Huggenberger, P., (2011), Modelling variable den- sity flow problems in heterogeneous porous media using the method of lines and advanced spatial discretization methods, Math. Comput. Simulat., 81, 2346-2355.
  • Teschl, G., (1991), Ordinary Differential Equations and Dynamical Systems, American Mathematical Society.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

S. Pamuk Bu kişi benim

I. Atac Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 3 Sayı: 2

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