Connected to Carbamazepine Complete Atrioventricular Block

Abstract

Carbamazepine is widely used for the treatment of neurological disorders and has cardiac side effects. After a very short and low dose carbamazepine therapy for post-stroke epilepsy, an 86 years old man experienced complete atrioventricular block. After discontinuation of carbamazepine, he returned to sinus rhythm. The present case suggests that, even for low dose and short course of therapy, carbamazepine might cause reversible complete atrioventricular block.

Keywords

• Carbamazepine, complete atrioventricular block, epilepsy

Karbamazepine Bağlı Atriyoventriküler Tam Blok

Öz

Karbamazepin nörolojik hastalıklarda yaygın kullanım alanı olan ve kardiyak yan etkiler gösterebilen bir ilaçtır. İnme sonrası epilepsi nedeniyle çok kısa süre karbamazepin tedavisi verilen ve ilaca bağlı atriyoventriküler tam blok gelişen 86 yaşında erkek hasta ilaç kesildikten kısa süre sonra sinüs ritmine döndü. Bu olgu, karbamazepinin kısa süreli ve düşük dozda verilmiş olsa dahi, geri dönüşümlü ileti sorunlarına yol açabileceğini göstermektedir.

Anahtar Kelimeler

• Atriyoventriküler tam blok, epilepsy, karbamazepin

Kaynakça

1. Armijo JA, Shushtarian M, Valdizan EM, Cuadrado A, de las Cuevas I, Adín J. Ion channels and epilepsy. Curr Pharm Des. 2005;11:1975-2003.
2. Herzberg L. Carbamazepine and bradycardia. Lancet 1978;1:1097-1098.
3. Ladefoged SD, Møgelvang JC. Total atrioventricular block with syncopes complicating carbamazepine therapy. Acta Med Scand. 1982;212:185-186.
4. Boesen F, Andersen EB, Jensen EK, Ladefoged SD. Cardiac conduction disturbances during carbamazepine therapy. Acta Neurol Scand. 1983;68:49-52.
5. Benassi E, Bo GP, Cocito L, Maffini M, Loeb C. Carbamazepine and cardiac conduction disturbances. Ann Neurol. 1987;22:280-281.
6. Gasperetti CM. Conduction abnormalities complicating carbamazepine therapy. Am J Med. 1987;82:381.
7. Labrecque J, Coté MA, Vincent P. Carbamazepineinduced atrioventricular block. Am J Psychiatry. 1992;149:572-573.
8. Ide A, Kamijo Y. Intermittent complete atrioventricular block after long term low-dose carbamazepine therapy with a serum concentration less than the therapeutic level. Intern Med. 2007;46:627-629.