Does Hemoglobine Level Play a Role in Metabolism of Succinylcholine

Abstract

Butyrylcholinesterase (BCHE) deficiency, several drugs or administration of high doses of succinylcholine (SCh) are well known reasons for prolonged succinylcholine clearance. The goal of this study was to investigate the relationship between hemoglobine (Hb) levels and SCh metabolism for the parturients undergoing cesarean sections. One hundred and twenty patients were randomized into three groups (n=40). In Group 1, the Hb levels of the patients were between 9-11 g dL–1. In Group 2, the levels were between 11 g dL–1 and 13 g dL–1. Finally in Group 3, the Hb levels of the patients were between 13-15 g dL–1. The BChE levels, Hb levels, the time for recovery of neuromuscular function were compared between groups. Group demographics were similar. There was no significant difference between Groups 1 and 2 regarding their drug elimination time (p>0.05). The recovery of neuromuscular functions was significantly faster in Group 3 (p<0.05). The results of our study suggest that anemia may cause prolonged SCh-induced paralysis and apnea for the patients undergoing cesarean section.

Keywords

• Succinylcholine, cesarean, hemoglobine, butyrylcholinesterase

Hemoglobin Düzeyi Süksinilkolin Metabolizmasında Rol Oynar mı?

Öz

Butiril kolinesteraz (BChE) eksikliği, çeşitli ilaçlar veya süksinilkolinin (SCh) yüksek dozda uygulanması uzamış süksinilkolin klirensinin iyi bilinen nedenlerindendir. Bu çalışmanın amacı sezeryan operasyonu geçiren gebelerde hemoglobin (Hb) düzeyleri ve SCh metabolizması arasındaki ilişkiyi araştırmaktır. Yüz yirmi hasta 3 farklı gruba (n=40) randomize edildi. Grup 1’e Hb düzeyi 9-11 g dL–1 arasındaki hastalar, Grup 2’ye 11 ile 13 g dL–1 arasında Hb düzeyi bulunan hastalar, Grup 3’e ise Hb düzeyi 13-15 g dL–1 arasında olan hastalar dahil edildi. Gruplar arasında BChE, Hb düzeyleri ve nöromüsküler fonksiyon geri dönüş zamanları karşılaştırıldı. Grupların demografik özellikleri benzerdi. Grup 1 ve 2’deki hastalar arasında ilaç eliminasyon zamanı bakımından anlamlı bir fark yoktu (p>0.05). Nöromüsküler fonksiyonların geri dönüşü Grup 3’de anlamlı olarak daha hızlıydı (p

Anahtar Kelimeler

• Çocuk hasta, üreter taşı, üreterolitiyazis, üreteroskopi, devlet hastanesi

Kaynakça

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