Association between Presence of Esophageal Varices on Endoscopy and Extreme Degree of F4-Stage Fibrosis on Fibroscan in HCV-Related Chronic Liver Disease

Yıl 2018, , 85 - 89, 01.04.2018

Mehvish Amin Malik Abdul Jabbar Hanan Ahmad - Samar

https://doi.org/10.5455/umj.20180312034434

Öz

Background: Hepatitis C Virus HCV infection is one of the causes which cause liver fibrosis, cirrhosis and carcinoma if left untreated. Patients who present with acute HCV infection, 50-70% of them develop chronic infection. This study attempted to see an association between F4 fibrosis in liver on fibroscan and esophageal varices on endoscopy in HCV related chronic liver disease CLD patients. Method: This study was conducted in Gastroenterology and Hepatology division of holy family hospital, Rawalpindi. Total 117 patients of 10 to 90 years were included. All patients were having HCV related CLD. Patients having F4 fibrosis stage were included while patients having fibrosis stage up to F3 fibrosis stage were excluded. All data regarding age, gender, F4 fibrosis and esophageal varices was entered and analyzed using the statistical package of social sciences while descriptive analysis was performed. Results: Amongst 114 patients who presented with F4 fibrosis stage on fibroscan 69.3% 79 of them were diagnosed for esophageal varices on endoscopy and 30.7% 35 were not having esophageal varices on endoscopy. Patients who were having esophageal varices on endoscopy 84.5% 49 of them were males and 55.9% 33 were females. Study participants having F4 fibrosis stage, 98.3% of them were males and 96.6% were females. So, there was not much difference between males and females having an extreme degree of fibrosis on fibroscan. Conclusion: Patients who were having F4 fibrosis stage on fibroscan, 2/3 of them were having esophageal varices on endoscopy. Esophageal varices were more present in males as compared to females.

Anahtar Kelimeler

Hepatitis C Virus, chronic liver disease, esophageal varices

Kaynakça

• 1. WHO. What is hepatitis?http://www.who.int/features/qa/ 76/en. (Accessed 10 September 2017)
• 2. Hepatitis (Viral Hepatitis, A, B, C, D, E, G) http://www. medicinenet.com/viral_hepatitis/article.htm. (Accessed 10 September 2017)
• 3. WHO. Hepatitis C. www.who.int/mediacentre/factsheets/ fs164/en. (Accessed 10 september 2017)
• 4. Quershi, H; bile, KM; Jooma et al. Eastern Mediterranean Health Journal, suppl. Supplement; Alexandria 16 (Aug 2010): S15-23.
• 5. Vizzutti F, Arena U, Romanelli RG, Rega L, Foschi M, Colagrande S et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. May 2007;45 (5):1290-7.
• 6. Bureau C, Metivier S, Peron JM, Selves J, Robic MA, Gourroud PA, et al. Transient elastography accurately predict the presence of significant portal hypertension in patients with the chronic liver disease. Alimentary pharmacology and therapeutics. 2008; 27(12):1261-8.
• 7. Colecchia A, Montrone N, Scailoi E, Bacchi-Reggiani ML, Colli A, Casazza G, et al. Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis. Gastroenterology 2012;143(3):646-4.
• 8. Augustin S, Millan M, Gonzalez A, Martell M, Gelabert A, Segarra A, et al. Detection of early portal hypertension with routine data and liver stiffness in patients with asymptomatic liver disease: A prospective study. Journal of Hepatology. 2014; 60(3):561-9.
• 9. Leomine M, Katsahian S, Ziol M, Nahon P, Ganne-Carrie N, Kazemi F, et al. Liver stiffness measurement as a predictive tool of clinically significant portal hypertension in patients with compensated hepatitis C or alcohol-related cirrhosis. Aliment Pharmacol Ther. 2008 Nov 1; 28(9):1102-10.
• 10. Helmy, Ali AZ, Hamed, et al. Transient elastography (Fibroscan) in the prediction of esophageal varices in hepatitis C virus-related chronic liver disease: an Egyptian experience. Egyptian liver journal 2016; 6(3):43-47.
• 11. Vizzutti F, Arena U, Romanelli RG, Rega L, Foschi M, Colagrande S et al. Liver Stiffness Measurement Predicts Severe Portal Hypertension in Patients with HCV-Related Cirrhosis. Hepatology 2005; 45(5):1290-7