Is There Any Relationship Between Circulating Serum 25-Hydroxyvitamin D Level and Presence of Helicobacter Pylori As Well As Gastric Inflammation Severity?

Yıl 2019, , 84 - 90, 01.01.2019

Tarik Akar

https://doi.org/10.5455/umj.20190227101537

Öz

Background: Helicobacter Pylori H. Pylori and ongoing chronic gastric inflammation are the most crucial factors leading to gastric cancer. The serum 25 Hydroxyvitamin D is the fundamental keys to the proper functioning of the immune system and reduction of inflammation. The primary aim of this study is to evaluate the association between the serum level of 25 Hydroxyvitamin D and the presence of H. Pylori as well as gastric inflammation. Materials and Methods: A total of 91 18-85 years old dyspeptic patients having a standard laboratory parameter hematologic, liver and kidney without chronic medical problems and were enrolled in this study. During an upper endoscopy, at least four stomach biopsies were taken and evaluated according to Sydney classification. The serum 25-Hydroxyvitamin D level was also calculated at the same time endoscopy. Results: In population, 48 52.7% were H. Pylori positive, while 41 47.3% were H. Pylori negative. The mean age, gender, hemoglobin, mean corpuscular volume, mean platelet volume, CRP, ferritin, red cell distribution width, endoscopic findings, and iron were similar in two groups p0.05 . The serum 25-Hydroxyvitamin D levels were similar in groups of H. Pylori positive and negative. Conclusion: This is the first study investigating the relationship between the serum 25-Hydroxyvitamin D level and H. Pylori as well as gastric inflammation sub-groups. Consequently, we found no relationship between serum 25 Hydroxyvitamin D level and H. Pylori as well as gastric inflammation severity.

Anahtar Kelimeler

25-Hydroxyvitamin D, Helicobacter pylori, gastric inflammation, gastritis, Turkey

Kaynakça

• Shetty V, Ballal M, Balaraju G, Shetty S, Pai GC, Lingadakai R. Helicobacter pylori in Dyspepsia: Phenotypic and Genotypic Methods of Diagnosis. J Glob Infect Dis. 2017; (4):131-4
• Moayyedi PM, Lacy BE, Andrews CN, Enns RA, Howden CW, Vakil N. ACG and CAG Clinical Guideline: Management of Dyspepsia. Am J Gastroenterol. 2017;112 (7):988-1013
• Muhammad JS, Zaidi SF, Saeed SA, Ishaq M. Current status of Helicobacter pylori association with haematological and cardiovascular diseases: A mini review. J Pak Med Assoc. 2017;67(6):907-11
• Badary DM, Rahma MZAA, Ashmawy AM, Hafez MZ. H. pylori infection increases gastric mucosal COX2 and mTOR expression in chronic gastritis: Implications for cancer progression? Pathophysiology. 2017;24(3):205-11
• Dolak W, Bilgilier C, Stadlmann A, Leiner J, Püspök A, Plieschnegger W, et al. A multicenter prospective study on the diagnostic performance of a new liquid rapid urease test for the diagnosis of Helicobacter pylori infection. Gut Pathog. 2017;9:78
• Guo L, Chen W, Zhu H, Chen Y, Wan X, Yang N, et al. Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses. Helicobacter. ;19(1):37-47
• Walker RE, Bartley J, Camargo CA, Flint D, Thompson JMD, Mitchell EA. Higher serum 25(OH)D concentration is associated with lower risk of chronic otitis media with effusion: a case-control study. Acta Paediatr. 2017;106 (9):1487-92
• Antico A, Tozzoli R, Giavarina D, Tonutti E, Bizzaro N. Hypovitaminosis D as predisposing factor for atrophic type A gastritis: a case-control study and review of the literature on the interaction of Vitamin D with the immune system. Clin Rev Allergy Immunol. 2012;42(3):355-64
• Bae KN, Nam HK, Rhie YJ, Song DJ, Lee KH. Low levels of hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience. Ann Pediatr Endocrinol Metab. 2018;23(1):21-7
• Caraba A, Crişan V, Romoşan I, Mozoş I, Murariu M. Vitamin D Status, Disease Activity, and Endothelial Dysfunction in Early Rheumatoid Arthritis Patients. Dis Markers. 2017;2017:5241012
• D'Aurizio F, Villalta D, Metus P, Doretto P, Tozzoli R. Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases? Autoimmun Rev. 2015;14 (5):363-9
• Jokar A, Ahmadi K, Taherinia A, Didgar F, Kazemi F, Bahramian M. The Effects of Injected Vitamin D on Prognosis of Patients with Urosepsis. Horm Metab Res. De Pergola G, Triggiani V, Bartolomeo N, Giagulli VA, Anelli M, Masiello M, et al. Low 25 Hydroxyvitamin D Levels are Independently Associated with Autoimmune Thyroiditis in a Cohort of Apparently Healthy Overweight and Obese Subjects. Endocr Metab Immune Disord Drug Targets. 2018
• Jiménez-Sousa M, Martínez I, Medrano LM, Fernández- Rodríguez A, Resino S. Vitamin D in Human Immuno deficiency Virus Infection: Influence on Immunity and Disease. Front Immunol. 2018;9:458
• Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017;5(11):881-90
• Minalyan A, Benhammou JN, Artashesyan A, Lewis MS, Pisegna JR. Autoimmune atrophic gastritis: current perspectives. Clin Exp Gastroenterol. 2017;10:19-27
• Navarrete-Dechent C, Del Puerto C, Molgó M, González S, Pérez-Mateluna G, Uribe P, et al. Circulating vitamin D- binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma: A case-control study. J Am Acad Dermatol. 2017;77(3):575-7
• Rafiq R, Thijs W, Prein R, de Jongh RT, Taube C, Hiemstra PS, et al. Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population. Nutrients. 2018;10(1)
• Moschonis G, Androutsos O, Hulshof T, Dracopoulou M, Chrousos GP, Manios Y. Vitamin D insufficiency is associated with insulin resistance independently of obesity in primary schoolchildren. The Healthy Growth Study. Pediatr Diabetes. 2018
• Yildirim O, Yildirim T, Seckin Y, Osanmaz P, Bilgic Y, Mete R. The influence of vitamin D deficiency on eradication rates of Helicobacter pylori. Adv Clin Exp Med. ;26(9):1377-81
• K, Nena E, Papanas N, Rizzo M, Voulgaris A, Xanthoudaki M, et al. Metabolic Syndrome and Vitamin D Levels in Patients with Obstructive Sleep Apnea Syndrome. Metab Syndr Relat Disord. 2018
• Costanzo M, Cesi V, Palone F, Pierdomenico M, Colantoni E, Leter B, et al. Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation. Benef Microbes. :1-12
• Wallbaum P, Rohde S, Ehlers L, Lange F, Hohn A, Bergner C, et al. Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells. World J Gastroenterol. ;24(2):170-8
• Llop SM, Davoudi S, Stanwyck LK, Sathe S, Tom L, Ahmadi T, et al. Association of Low Vitamin D Levels with Noninfectious Uveitisand Scleritis. Ocul Immunol Inflamm. :1-8