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High Preoperative Fibrinogen Level is Closely Associated with Receipt of Chemotherapy and Advanced Disease in Patients with Colorectal Cancer

Yıl 2017, Cilt: 3 Sayı: 4, 72 - 77, 01.10.2017
https://doi.org/10.5455/umj.20171115091720

Öz

Background: There is still lack of a preoperative simple, reliable and non-invasive blood marker predicting the stage of the disease luminal or extraluminal and the need for chemotherapy at the time of diagnosis in patients with colorectal cancer CRC . The study aimed to investigate any relationship between the preoperative fibrinogen level and CRC disease stage as well as the receipt of chemotherapy before surgery. Method: A total 297 CRC patients undergoing surgical resection for any reason curative or palliative enrolled in this study. The serum fibrinogen level was calculated in the preoperative period. The need for chemotherapy was assessed by two different expert oncologists. Comparisons were made between the fibrinogen level with disease stage as well as the chemotherapy. Results: The mean fibrinogen level was 455±128,5 mg/dL with high level in 77,4% of all CRC patients. The level of fibrinogen in both Duke’s C and D significantly were higher than Duke’s B p

Kaynakça

  • Lin CC, Bruinooge SS, Kirkwood MK, Olsen C, Jemal A, Bajorin D, et al. Association Between Geographic Access to Cancer Care, Insurance, and Receipt of Chemotherapy: Geographic Distribution of Oncologists and Travel Distance. J Clin Oncol. 2015;33(28):3177-85.
  • Vogel JD, Eskicioglu C, Weiser MR, Feingold DL, Steele SR. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer. Dis Colon Rectum. 2017;60(10):999-1017.
  • Yamashita H, Kitayama J, Taguri M, Nagawa H. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. World J Surg. ;33(6):1298-305.
  • Yamashita H, Kitayama J, Kanno N, Yatomi Y, Nagawa H. Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer. 2006;6:147.
  • Becerra AZ, Probst CP, Tejani MA, Aquina CT, González MG, Hensley BJ, et al. Evaluating the Prognostic Role of Elevated Preoperative Carcinoembryonic Antigen Levels in Colon Cancer Patients: Results from the National Cancer Database. Ann Surg Oncol. 2016;23(5):1554-61.
  • Kołodziejczyk J, Ponczek MB. The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression. Contemp Oncol (Pozn). 2013;17(2):113-9.
  • Adams GN, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, et al. Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. Cancer Res. 2015;75(19):4235-43.
  • Reitter EM, Kaider A, Ay C, Quehenberger P, Marosi C, Zielinski C, et al. Longitudinal analysis of hemostasis biomarkers in cancer patients during antitumor treatment. J Thromb Haemost. 2016;14(2):294-305.
  • Sun ZQ, Han XN, Wang HJ, Tang Y, Zhao ZL, Qu YL, et al. Prognostic significance of preoperative fibrinogen in patients with colon cancer. World J Gastroenterol. 2014;20(26):8583-91.
  • Perisanidis C, Psyrri A, Cohen EE, Engelmann J, Heinze G, Perisanidis B, et al. Prognostic role of pretreatment plasma fibrinogen in patients with solid tumors: A systematic review and meta-analysis. Cancer Treat Rev. 2015;41(10):960-70.
  • Web Page 2017 [Available from: https://www.medscape.com /viewarticle/439788_5.
  • Liska V, Treska V, Skalicky T, Fichtl J, Bruha J, Vycital O, et al. Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study. Anticancer Res. 2017;37(4):2003-9.
  • Lee S, Huh SJ, Oh SY, Koh MS, Kim SH, Lee JH, et al. Clinical significance of coagulation factors in operable colorectal cancer. Oncol Lett. 2017;13(6):4669-74.
  • Battistelli S, Stefanoni M, Lorenzi B, Dell'avanzato R, Varrone F, Pascucci A, et al. Coagulation factor levels in non-metastatic colorectal cancer patients. Int J Biol Markers. 2008;23(1):36-41.
  • Yamashita Y, Wada H, Nomura H, Mizuno T, Saito K, Yamada N, et al. Elevated fibrin-related markers in patients with malignant diseases frequently associated with disseminated intravascular coagulation and venous thromboembolism. Intern Med. 2014;53(5):413-9.
  • Kilic L, Yildiz I, Sen FK, Erdem MG, Serilmez M, Keskin S, et al. D-dimer and international normalized ratio (INR) are correlated with tumor markers and disease stage in colorectal cancer patients. Cancer Biomark. 2015;15(4):405-11.
  • Son HJ, Park JW, Chang HJ, Kim DY, Kim BC, Kim SY, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol. 2013;20(9):2908-13.
  • Kawai K, Kitayama J, Tsuno NH, Sunami E, Nagawa H. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. Int J Colorectal Dis. 2011;26(1):45-51.
  • Lee JH, Hyun JH, Kim DY, Yoo BC, Park JW, Kim SY, et al. The role of fibrinogen as a predictor in preoperative chemo radiation for rectal cancer. Ann Surg Oncol. 2015;22(1):209-15.
  • Motavaf E, Sunesen KG, Stender MT, Thorlacius-Ussing O. Prognostic value of preoperative D-dimer and carcinoem bryonic antigen levels in patients undergoing intended curative resection for colorectal cancer: a prospective cohort study. Int J Colorectal Dis. 2014;29(11):1427-32.
  • Lu K, Zhu Y, Sheng L, Liu L, Shen L, Wei Q. Serum fibrinogen level predicts the therapeutic response and prognosis in patients with locally advanced rectal cancer. Hepatogastro enterology. 2011;58(110-111):1507-10.
  • Rasic I, Radovic S, Aksamija G. Relationship Between Chronic Inflammation and the Stage and Histopathological Size of Colorectal Carcinoma. Med Arch. 2016;70(2):104-7. Abbreviations
Yıl 2017, Cilt: 3 Sayı: 4, 72 - 77, 01.10.2017
https://doi.org/10.5455/umj.20171115091720

Öz

Kaynakça

  • Lin CC, Bruinooge SS, Kirkwood MK, Olsen C, Jemal A, Bajorin D, et al. Association Between Geographic Access to Cancer Care, Insurance, and Receipt of Chemotherapy: Geographic Distribution of Oncologists and Travel Distance. J Clin Oncol. 2015;33(28):3177-85.
  • Vogel JD, Eskicioglu C, Weiser MR, Feingold DL, Steele SR. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer. Dis Colon Rectum. 2017;60(10):999-1017.
  • Yamashita H, Kitayama J, Taguri M, Nagawa H. Effect of preoperative hyperfibrinogenemia on recurrence of colorectal cancer without a systemic inflammatory response. World J Surg. ;33(6):1298-305.
  • Yamashita H, Kitayama J, Kanno N, Yatomi Y, Nagawa H. Hyperfibrinogenemia is associated with lymphatic as well as hematogenous metastasis and worse clinical outcome in T2 gastric cancer. BMC Cancer. 2006;6:147.
  • Becerra AZ, Probst CP, Tejani MA, Aquina CT, González MG, Hensley BJ, et al. Evaluating the Prognostic Role of Elevated Preoperative Carcinoembryonic Antigen Levels in Colon Cancer Patients: Results from the National Cancer Database. Ann Surg Oncol. 2016;23(5):1554-61.
  • Kołodziejczyk J, Ponczek MB. The role of fibrinogen, fibrin and fibrin(ogen) degradation products (FDPs) in tumor progression. Contemp Oncol (Pozn). 2013;17(2):113-9.
  • Adams GN, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, et al. Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. Cancer Res. 2015;75(19):4235-43.
  • Reitter EM, Kaider A, Ay C, Quehenberger P, Marosi C, Zielinski C, et al. Longitudinal analysis of hemostasis biomarkers in cancer patients during antitumor treatment. J Thromb Haemost. 2016;14(2):294-305.
  • Sun ZQ, Han XN, Wang HJ, Tang Y, Zhao ZL, Qu YL, et al. Prognostic significance of preoperative fibrinogen in patients with colon cancer. World J Gastroenterol. 2014;20(26):8583-91.
  • Perisanidis C, Psyrri A, Cohen EE, Engelmann J, Heinze G, Perisanidis B, et al. Prognostic role of pretreatment plasma fibrinogen in patients with solid tumors: A systematic review and meta-analysis. Cancer Treat Rev. 2015;41(10):960-70.
  • Web Page 2017 [Available from: https://www.medscape.com /viewarticle/439788_5.
  • Liska V, Treska V, Skalicky T, Fichtl J, Bruha J, Vycital O, et al. Evaluation of Tumor Markers and Their Impact on Prognosis in Gallbladder, Bile Duct and Cholangiocellular Carcinomas - A Pilot Study. Anticancer Res. 2017;37(4):2003-9.
  • Lee S, Huh SJ, Oh SY, Koh MS, Kim SH, Lee JH, et al. Clinical significance of coagulation factors in operable colorectal cancer. Oncol Lett. 2017;13(6):4669-74.
  • Battistelli S, Stefanoni M, Lorenzi B, Dell'avanzato R, Varrone F, Pascucci A, et al. Coagulation factor levels in non-metastatic colorectal cancer patients. Int J Biol Markers. 2008;23(1):36-41.
  • Yamashita Y, Wada H, Nomura H, Mizuno T, Saito K, Yamada N, et al. Elevated fibrin-related markers in patients with malignant diseases frequently associated with disseminated intravascular coagulation and venous thromboembolism. Intern Med. 2014;53(5):413-9.
  • Kilic L, Yildiz I, Sen FK, Erdem MG, Serilmez M, Keskin S, et al. D-dimer and international normalized ratio (INR) are correlated with tumor markers and disease stage in colorectal cancer patients. Cancer Biomark. 2015;15(4):405-11.
  • Son HJ, Park JW, Chang HJ, Kim DY, Kim BC, Kim SY, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol. 2013;20(9):2908-13.
  • Kawai K, Kitayama J, Tsuno NH, Sunami E, Nagawa H. Hyperfibrinogenemia after preoperative chemoradiotherapy predicts poor response and poor prognosis in rectal cancer. Int J Colorectal Dis. 2011;26(1):45-51.
  • Lee JH, Hyun JH, Kim DY, Yoo BC, Park JW, Kim SY, et al. The role of fibrinogen as a predictor in preoperative chemo radiation for rectal cancer. Ann Surg Oncol. 2015;22(1):209-15.
  • Motavaf E, Sunesen KG, Stender MT, Thorlacius-Ussing O. Prognostic value of preoperative D-dimer and carcinoem bryonic antigen levels in patients undergoing intended curative resection for colorectal cancer: a prospective cohort study. Int J Colorectal Dis. 2014;29(11):1427-32.
  • Lu K, Zhu Y, Sheng L, Liu L, Shen L, Wei Q. Serum fibrinogen level predicts the therapeutic response and prognosis in patients with locally advanced rectal cancer. Hepatogastro enterology. 2011;58(110-111):1507-10.
  • Rasic I, Radovic S, Aksamija G. Relationship Between Chronic Inflammation and the Stage and Histopathological Size of Colorectal Carcinoma. Med Arch. 2016;70(2):104-7. Abbreviations
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Research Article
Yazarlar

Tarik Akar

Yayımlanma Tarihi 1 Ekim 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 3 Sayı: 4

Kaynak Göster

Vancouver Akar T. High Preoperative Fibrinogen Level is Closely Associated with Receipt of Chemotherapy and Advanced Disease in Patients with Colorectal Cancer. ULUTAS MED J. 2017;3(4):72-7.