Assessment of New Biomarkers Used in the Diagnosis of Acute Appendicitis in Children

Yıl 2019, Cilt: 5 Sayı: 2, 149 - 154, 01.04.2019

Onur Yalcin , Ali Aygun Emine Yurdakul Erturk

https://doi.org/10.5455/umj.20190227010808

Öz

Background: Acute appendicitis AA is the most frequent cause of acute abdomen among pathologies and diagnosis can be difficult in pediatric patients. Our purpose was to examine the initially checked hemogram parameters and C-Reactive protein CRP of patients operated with the diagnosis of acute appendicitis in children and to find out the significance of these in diagnosis. Materials and Methods: The study was conducted in a tertiary pediatric hospital. Patients younger than 18 years of age diagnosed with acute abdomen diagnosis between May 2017 and December 2018 were included in the study. Patients’hemogram parameters and CRP at the time of diagnosis and their post-surgery pathology results were examined retrospectively. The patients were grouped in two as those who were operated with a diagnosis of AA GroupA and those who had abdominal pain but who were clinically followed without operation Group B . Results: 103 patients diagnosed with acute abdomen younger than 18 years of age were included in our study.71.8% of the patients were male, while 28.2% were female. The average age of the patients was 9.74±3.36 years.24 of the patients had suspicious laboratory and radiological examinations USGorCT with abdominal pain were clinically followed and discharged without operation.79 patients were operated and AA symptoms were found in surgical pathology results. In the comparison of hemogram parameters of patients in Group A and Group B, a statistically significant difference was found between WBC, neutrophil count, neutrophil/lymphocyte ratio NLR , platelet/ lymphocyte ratio PLR and CRP, p

Anahtar Kelimeler

Abdominal pain, acute appendicitis, paediatric, hemogram

Kaynakça

• 1. Menteş Ö, Eryılmaz M, Yiğit T, Tascı S., Balkan M., Kozak O. ve ark. 60 yaş üstü apandektomili olgularımızın retrospektif analizi. JAEM 2008;7:36-41
• 2. Saraç M, Bakal Ü, Tartar T, Kazez A. Apandisitlerin perfore olmasında hekimlerin rolü. Firat Med J 2014;19: 126-29
• 3. Mengucuk ME, Ayten R, Bulbuller N, Godekmerdan A, Basbug M, Mungan I. The place of serum C-reactive protein, procalcitonin, and neopterin in the diagnosis of acute appendicitis. Firat Medical Journal 2010;15:40-3
• 4. Gokce AH, Aren A, Gokce FS, Dursun N, Barut AY. Reliability of ultrasonography for diagnosing acute appendicitis. Ulus Travma Acil Cerrahi Derg 2011;17:19-22
• 5. Binnebosel M, Otto J, Stumpf M, Mahnken AH, Gassler N, Schumpelick V, et al. Acute appendicitis. Modern diagnostics-surgical ultrasound. Chirurg 2009;80:579-87
• 6. Demircan A, Aygencel G, Karamercan M, Ergin M, Yilmaz TU, Karamercan A. The evaluation of ultrasonographic findings and white blood cell count in patients who underwent laparotomy with the diagnosis of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2010;16:248-52
• 7. Aygun A, Katipoglu B, Imamoglu M, Demir S, Yadigaroglu M, Tatli O, et al. Diagnostic Value of Plasma Pentraxin-3 in Acute Appendicitis. J Invest Surg. 2017;11:1-6
• 8. Sevim Y, Namdaroglu OB, Akpınar MY, Ertem AG. Akut Apandisitte Nötrofil Lenfosit Oranının Tanısal Değeri. Sakaryamj 2014;4:78-81
• 9. Yıldız T., Bozdag Z., Erkorkmaz U., Emre A., Turgut T., İlce Z. Analysis of risk factors for the development of pediatric appendicitis. Ulus Travma Acil Cerr Derg 2013;19:554-8
• 10.Sulu B, Günerhan Y, Palanci Y, Işler B, Cağlayan K. Epidemiological and demographic features of appendicitis and influences of several environmental factors. Ulus Travma Acil Cerrahi Derg 2010;16:38-42
• 11. Al-Omran M, Mamdani M, McLeod RS. Epidemiologic features of acute appendicitis in Ontario, Canada. Can J Surg 2003;46:263-8
• 12.Kapcı M, Türkdoğan KA, Duman A, Avcil M, Gülen B, Ugurlu Y et al. Biomarkers in the diagnosis of acute appendicitis. J Clin Exp Invest.2014;5:250-5
• 13.Peng W, Li C, Wen TF, Yan LN, Li B, Wang WT, et al. Neutrophil to lymphocyte ratio changes predict small hepatocellular carcinoma survival. JSurg Res 2014;192:402-8
• 14. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9
• 15.Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis. Acta Chir Belg 2010;110:543-7
• 16.Goodman DA, Goodman CB, Monk JS. Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. Am Surg 1995;61:257-9
• 17.Tanrikulu CS, Tanrikulu Y, Sabuncuoglu MZ, Karamercan MA, Akkapulu N, Coskun F. Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis. Iran Red Crescent Med J 2014;16:e10211
• 18.Acar E, Ozcan O, Deliktas H, Beydilli H, Kırlı İ, Alatas OD et al. Laboratory markers has many valuable parameters in the discrimination between acute appendicitis and renal colic. Ulus Travma Acil Cerrahi Derg. 2016 22:17-22
• 19.Çınar H, Aygün A, Derebey M, Tarım İA, Akalın Ç, Büyükakıncak S, Erzurumlu K. Ulus Travma Acil Cerrahi Derg. 2018 24 (5) :423-8