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Yıl 2021, Cilt: 7 Sayı: 2, 89 - 91, 25.06.2020
https://doi.org/10.5455/umj.20210422011242

Öz

Kaynakça

  • 1. Rudra P, Basak S, Patil D, Latoo MY. Recent advances in management of preeclampsia. Br J Medical Pract. 2011;4:9433
  • 2. Magee LA, Helewa M, Pey E, von Dadelszen P. The hypertensive disorder of pregnancy. Best Pract Res Clin Obstet Gynecol. 2015;29:643-657
  • 3. American College of Obstetricians and Gynaecologists. Hypertension in Pregnancy. Task Force on Hypertension and Pregnancy. 2013;1122-1133
  • 4. Mc Clure EM, Saleem S, Pascha O, Goldenberg RL. Stillbirth in developing countries: A review of causes, risk factors and prevention strategies. J Matern Fetal Neonatol Med. 2009;22:183-190
  • 5. Shab A, Fawole JM’Umonya. Cesearean delivery outcomes from the WHO global survey on maternal and perinatal health in Africa. Int J Gynaecol Obstet. 2009;107:191-197
  • 6. Adiga U, D’Souza V, Kamath A, Mangalore N. Antioxidant activity and lipid peroxidation in preeclampsia. J Clin Med. 2007; 70:435-458
  • 7. Gohil JT, Patel PK, Gupta P. Evaluation of oxidative stress and antioxidant defence in subject of Preeclampsia. J Obstet Gynaecol. 2012;61:638-640
  • 8. Caughey AB, Stotland NE,Washington AE, Escobar GJ. Maternal ethnicity, paternal ethnicity and parental ethnic discordance: Predictors of preeclampsia in Obstetrics and Gynecology. 2005;195:148
  • 9. James DK, Seely PJ, Weiner CP, Gonlk B. High risk pregnancy management options 3rd edition. Philadelphia Sauders. 2006; 920-925
  • 10.Al-Jameil N, Aziz KF, Fareed Km, Tabassum H. A brief overview of preeclampsia. J Clin Med Res. 2014;6:1-7
  • 11. Yaliwal RG, Taju PB, Vanishree M. Eclampsia and perinatal outcome a retrospective study in a teaching hospital. J Clin Diag. 2011;5:1056-1059
  • 12.Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, et al. Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards millennium development goals 5. The Lancet. 2010;375:1609-1623
  • 13.Oladape O, Adetoro O, Ekele B, Chama C, Etok S, Aboyeji A, Gulmezoglu A. When getting there is not enough: A nationwide cross section study of 998 maternal deaths and 1451 near-misses in public tertiary hospital in a low income country. Int J Obstet Gynecol. 2015;10:10528-13458
  • 14.American Public Health Association. Direct Air-Acetylene Flame Method Standard Methods for the Examination of Metals in Blood. 20th ed. Washington DC: American Public Health Association; 1995
  • 15.Gutteridge JM, Wilkins S. Copper dependent hydroxyl radical damage to ascorbic acid, formation of thiobarbituric acid reactive products. FEBS Letts. 1982;137:327-330
  • 16.Olife IC, Okaka AN, Dioka CE, Meludu SC, Orisakwe OE. Iodine status and the effect of soil erosion on trace elements in Nanka and Oba towns of Anambra State Nigeria. Annals of Chemistry. 2007; 97:895-903
  • 17.Maleki A, Fard MK, Zadeh DH, Mamegani MA, Abasaizadeh S, Mazloomzadeh. The relationship between plasma level of Selenium and preeclampsia. Hypertension in Pregnancy. 2011; 30:180-187
  • 18.Vandelie J, Perkins A. Selenium and preeclampsia: A global perspective. Hypertens Pregnancy. 2011;1:213-224
  • 19.Nwagha UI, Ogbodo SO, Nwogu-Ikojo EE, Ibegbu DM, Ejezie FE, Nwagha TU, et al. Copper and selenium status of healthy pregnant women in Enugu, Southeastern Nigeria. Nig J Clin Pract. 2011;14:408-412
  • 20. Karita K, Takano T, Satoh K.Variations in plasma selenium levels as a result of the menstrual cycle and pregnancy in healthy Japanese women. Biol Trace Elem Res. 2004; 99:83
  • 21. Garg HK, Singhai KC and Arshad. A study of the effect of oral zinc supplementation during pregnancy on outcome. Indian J Physiol Pharmacol. 1993;37:276-284
  • 22. Tamura T, Goldenberg RL, Johnston KE, Dubard M. Maternal plasma zinc concentrations and pregnancy outcome. Am J Clin Nutr. 2000;71:109-113
  • 23. Caulfield LE, Zavaleta N, Figuena A, Leon Z. Zinc supplementation does not affect size at birth or pregnancy duration in Peru. J Nutr. 1998;129:1567-1568
  • 24. Swanson CA and King JC. Zinc and pregnancy outcome. Am J Clin Nutr. 1987;46:763-771
  • 25.Moyene JE, Scheers H, Jandumba, Haufroid V, Buassa-bu-Tsumbu B, Verdonck F, Spitz B, et al. Preeclampsia and toxic metal. A case control study in Kinshana DR Congo. Environ Health. 2016;15:48
  • 26.Milne DB, Carel AB, Edward RA, Tietz. Textbook of Clinical Chemistry.3rd Edition. Saunders Company. 1999;1029-1041
  • 27.O’Brien KO, Zaraleta N, Caulfield LE, Wen J, Abrams SA. Prenatal iron supplement, impair zinc absorption in pregnant Perovian women. J Nutr. 2000; 130:2251-2255
  • 28. Hambidger K, Krebs NF, Sibley L, English L. Acute effects of iron therapy on zinc status during pregnancy. Obstet Gynaecol. 1987;70:593-596
  • 29. Jain S, Sharma P, Kulshreshtha S, Mohen G, Singh S. The role of calcium, magnesium and zinc in preeclampsia. Biol Trace Elem Res. 2010;133:162-170
  • 30. Sarwar MS, Ahmed S, Ullah MS, Kabir H, Rahmar GK, Hasnat A, et al. Comparative study of serum, zinc, copper, manganese and iron in prepregnant women. Biol Trace Elem Res. 2013;154:14-20
  • 31. Golmohammad, Lou S, Amivahi A, Yazdian M, Pashapur N. Evaluation of serum calcium, magnesium, copper and zinc levels in women with preeclampsia. Iranian J Med Sci. 2008; 33:235-238
  • 32. Ugwuja EI, Ejikeme BN, Ugwuja NC, Obeka NC, Akubugwo EI, Obidoa O. Comparison of plasma copper, iron and zinc levels in hypertensive and non-hypertensive pregnancy women in Abakaliki, South East Nigeria. Pakistan J Nutr. 2010;9:1136-1140
  • 33. Chan S, Gerson B, Subraman IM. The role of copper, molybdenum, selenium and zinc in nutrition and health. Clin Lab Med. 1998;18:673-685
  • 34. Acikgoz S, Harma M, Harma M, Mongan G, Can M, Demirtas. Comparison of angiotensin converting enzyme, MDA, zinc and copper levels in preeclampsia. Biol Trace Elem Res. 2006;113:1-8
  • 35. Patil SB, Kodiwadmath MV, Kadiwadmath SM. Role of lipid peroxidation and enzymatic antioxidants in pregnancy induced hypertension. Clin Exp Obstet Gynaecol. 2007;34:239-241
  • 36. Nnodim J, Ihim A, Uduji HI. Alterations in antioxidant Enzyme and Malondialdehyde status in preeclampsia. Asian Pac J Trop Biomed. 2012;5750-5752
  • 37. Guphta A, Kant S, Gupta SK, Prakash S, Kalaivani M, Pandav CS, et al. Serum FRAP levels and preeclampsia among pregnant women in a rural community of Northern India. J Clin Diag Res. 2016;102:12-15

Evaluation of Plasma Selenium, Zinc and Malondialdehyde Levels in Newly Diagnosed Preeclamptic Women at A Teaching Hospital

Yıl 2021, Cilt: 7 Sayı: 2, 89 - 91, 25.06.2020
https://doi.org/10.5455/umj.20210422011242

Öz

Introduction: Preeclampsia is a clinical condition unique to humans which forms a major part of hypertensive disorders in pregnancy. Although its exact etiology remains unknown, an imbalance between lipid peroxides and antioxidants is implicated. The study aimed to evaluate plasma selenium, zinc, and malondialdehyde (MDA) levels in newly diagnosed preeclamptic women attending antenatal visits at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka in Anambra State.
Materials and Methods: A total of 81 female participants were recruited and grouped into three (A, B, and C) comprising 21 newly diagnosed preeclamptic women, 30 healthy pregnant control, and 30 non-pregnant control participants respectively.
Results: The newly diagnosed preeclamptics had significantly lower plasma selenium levels when compared with the healthy pregnant and non-pregnant controls (p<0.05). The plasma zinc level in the preeclamptics did not differ significantly from the level in healthy pregnant women (p>0.05), it was however significantly lower in the preeclamptics and healthy pregnant women when compared with the non-pregnant women (p<0.05). Plasma MDA level was significantly elevated in the preeclamptics compared to the healthy pregnant and non-pregnant control participants (p<0.05).
Conclusion: Newly diagnosed preeclamptics have lower plasma selenium and zinc levels with higher plasma MDA levels, and additional sources of these micronutrients may be required.

Kaynakça

  • 1. Rudra P, Basak S, Patil D, Latoo MY. Recent advances in management of preeclampsia. Br J Medical Pract. 2011;4:9433
  • 2. Magee LA, Helewa M, Pey E, von Dadelszen P. The hypertensive disorder of pregnancy. Best Pract Res Clin Obstet Gynecol. 2015;29:643-657
  • 3. American College of Obstetricians and Gynaecologists. Hypertension in Pregnancy. Task Force on Hypertension and Pregnancy. 2013;1122-1133
  • 4. Mc Clure EM, Saleem S, Pascha O, Goldenberg RL. Stillbirth in developing countries: A review of causes, risk factors and prevention strategies. J Matern Fetal Neonatol Med. 2009;22:183-190
  • 5. Shab A, Fawole JM’Umonya. Cesearean delivery outcomes from the WHO global survey on maternal and perinatal health in Africa. Int J Gynaecol Obstet. 2009;107:191-197
  • 6. Adiga U, D’Souza V, Kamath A, Mangalore N. Antioxidant activity and lipid peroxidation in preeclampsia. J Clin Med. 2007; 70:435-458
  • 7. Gohil JT, Patel PK, Gupta P. Evaluation of oxidative stress and antioxidant defence in subject of Preeclampsia. J Obstet Gynaecol. 2012;61:638-640
  • 8. Caughey AB, Stotland NE,Washington AE, Escobar GJ. Maternal ethnicity, paternal ethnicity and parental ethnic discordance: Predictors of preeclampsia in Obstetrics and Gynecology. 2005;195:148
  • 9. James DK, Seely PJ, Weiner CP, Gonlk B. High risk pregnancy management options 3rd edition. Philadelphia Sauders. 2006; 920-925
  • 10.Al-Jameil N, Aziz KF, Fareed Km, Tabassum H. A brief overview of preeclampsia. J Clin Med Res. 2014;6:1-7
  • 11. Yaliwal RG, Taju PB, Vanishree M. Eclampsia and perinatal outcome a retrospective study in a teaching hospital. J Clin Diag. 2011;5:1056-1059
  • 12.Hogan MC, Foreman KJ, Naghavi M, Ahn SY, Wang M, Makela SM, et al. Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards millennium development goals 5. The Lancet. 2010;375:1609-1623
  • 13.Oladape O, Adetoro O, Ekele B, Chama C, Etok S, Aboyeji A, Gulmezoglu A. When getting there is not enough: A nationwide cross section study of 998 maternal deaths and 1451 near-misses in public tertiary hospital in a low income country. Int J Obstet Gynecol. 2015;10:10528-13458
  • 14.American Public Health Association. Direct Air-Acetylene Flame Method Standard Methods for the Examination of Metals in Blood. 20th ed. Washington DC: American Public Health Association; 1995
  • 15.Gutteridge JM, Wilkins S. Copper dependent hydroxyl radical damage to ascorbic acid, formation of thiobarbituric acid reactive products. FEBS Letts. 1982;137:327-330
  • 16.Olife IC, Okaka AN, Dioka CE, Meludu SC, Orisakwe OE. Iodine status and the effect of soil erosion on trace elements in Nanka and Oba towns of Anambra State Nigeria. Annals of Chemistry. 2007; 97:895-903
  • 17.Maleki A, Fard MK, Zadeh DH, Mamegani MA, Abasaizadeh S, Mazloomzadeh. The relationship between plasma level of Selenium and preeclampsia. Hypertension in Pregnancy. 2011; 30:180-187
  • 18.Vandelie J, Perkins A. Selenium and preeclampsia: A global perspective. Hypertens Pregnancy. 2011;1:213-224
  • 19.Nwagha UI, Ogbodo SO, Nwogu-Ikojo EE, Ibegbu DM, Ejezie FE, Nwagha TU, et al. Copper and selenium status of healthy pregnant women in Enugu, Southeastern Nigeria. Nig J Clin Pract. 2011;14:408-412
  • 20. Karita K, Takano T, Satoh K.Variations in plasma selenium levels as a result of the menstrual cycle and pregnancy in healthy Japanese women. Biol Trace Elem Res. 2004; 99:83
  • 21. Garg HK, Singhai KC and Arshad. A study of the effect of oral zinc supplementation during pregnancy on outcome. Indian J Physiol Pharmacol. 1993;37:276-284
  • 22. Tamura T, Goldenberg RL, Johnston KE, Dubard M. Maternal plasma zinc concentrations and pregnancy outcome. Am J Clin Nutr. 2000;71:109-113
  • 23. Caulfield LE, Zavaleta N, Figuena A, Leon Z. Zinc supplementation does not affect size at birth or pregnancy duration in Peru. J Nutr. 1998;129:1567-1568
  • 24. Swanson CA and King JC. Zinc and pregnancy outcome. Am J Clin Nutr. 1987;46:763-771
  • 25.Moyene JE, Scheers H, Jandumba, Haufroid V, Buassa-bu-Tsumbu B, Verdonck F, Spitz B, et al. Preeclampsia and toxic metal. A case control study in Kinshana DR Congo. Environ Health. 2016;15:48
  • 26.Milne DB, Carel AB, Edward RA, Tietz. Textbook of Clinical Chemistry.3rd Edition. Saunders Company. 1999;1029-1041
  • 27.O’Brien KO, Zaraleta N, Caulfield LE, Wen J, Abrams SA. Prenatal iron supplement, impair zinc absorption in pregnant Perovian women. J Nutr. 2000; 130:2251-2255
  • 28. Hambidger K, Krebs NF, Sibley L, English L. Acute effects of iron therapy on zinc status during pregnancy. Obstet Gynaecol. 1987;70:593-596
  • 29. Jain S, Sharma P, Kulshreshtha S, Mohen G, Singh S. The role of calcium, magnesium and zinc in preeclampsia. Biol Trace Elem Res. 2010;133:162-170
  • 30. Sarwar MS, Ahmed S, Ullah MS, Kabir H, Rahmar GK, Hasnat A, et al. Comparative study of serum, zinc, copper, manganese and iron in prepregnant women. Biol Trace Elem Res. 2013;154:14-20
  • 31. Golmohammad, Lou S, Amivahi A, Yazdian M, Pashapur N. Evaluation of serum calcium, magnesium, copper and zinc levels in women with preeclampsia. Iranian J Med Sci. 2008; 33:235-238
  • 32. Ugwuja EI, Ejikeme BN, Ugwuja NC, Obeka NC, Akubugwo EI, Obidoa O. Comparison of plasma copper, iron and zinc levels in hypertensive and non-hypertensive pregnancy women in Abakaliki, South East Nigeria. Pakistan J Nutr. 2010;9:1136-1140
  • 33. Chan S, Gerson B, Subraman IM. The role of copper, molybdenum, selenium and zinc in nutrition and health. Clin Lab Med. 1998;18:673-685
  • 34. Acikgoz S, Harma M, Harma M, Mongan G, Can M, Demirtas. Comparison of angiotensin converting enzyme, MDA, zinc and copper levels in preeclampsia. Biol Trace Elem Res. 2006;113:1-8
  • 35. Patil SB, Kodiwadmath MV, Kadiwadmath SM. Role of lipid peroxidation and enzymatic antioxidants in pregnancy induced hypertension. Clin Exp Obstet Gynaecol. 2007;34:239-241
  • 36. Nnodim J, Ihim A, Uduji HI. Alterations in antioxidant Enzyme and Malondialdehyde status in preeclampsia. Asian Pac J Trop Biomed. 2012;5750-5752
  • 37. Guphta A, Kant S, Gupta SK, Prakash S, Kalaivani M, Pandav CS, et al. Serum FRAP levels and preeclampsia among pregnant women in a rural community of Northern India. J Clin Diag Res. 2016;102:12-15
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Research Article
Yazarlar

Obianuju Ilechukwu Bu kişi benim 0000-0001-9645-0871

Yayımlanma Tarihi 25 Haziran 2020
Gönderilme Tarihi 9 Mart 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 7 Sayı: 2

Kaynak Göster

Vancouver Ilechukwu O. Evaluation of Plasma Selenium, Zinc and Malondialdehyde Levels in Newly Diagnosed Preeclamptic Women at A Teaching Hospital. ULUTAS MED J. 2020;7(2):89-91.