Alterations in Some Blood Parameters After High Level Ethanol Intake

Öz

Anahtar Kelimeler

• -

Alterations in Some Blood Parameters After High Level Ethanol Intake

Öz

Yüksek seviyede etanol alımının bazı kan parametreleri üzerine etkisi, 50 günlük bir periyotta 3 gruba bölünmüş 36 Sprague Dawley ırkı sıçanda incelendi. Çalışmadaki gruplar; ad libitum beslenen kontrol grubu, etanol grubundaki sıçanlar ile eşit kalori alması için sükroz solüsyonu verilen sükroz grubu ve içme sularına etanol eklenen (% 15 v/v) etanol grubuydu. Etanol grubundaki sıçanların akyuvar ve alyuvar sayılarında, hemoglobin konsantrasyonlarında eritrosit çaplarında, eritrosit sodyum ve potasyum seviyelerinde istatistiksel açıdan önemli (p

Anahtar Kelimeler

• Etanol, kan parametreleri, etanolun enerjisi

Kaynakça

1. MARIETTA CA, JERRELLS TR, MEAGHER RC, KARANIAN JW, WEIGHT FF, ECKARDT MJ. Effects of long-term ethanol inhalation on the immune and hematopoietic systems of the rat. Alcohol. Clin. Exp. Res., 1988; 12(2): 211-214.
2. GIGLIO MJ, SANTORO RC, BOZZINI CE. Effect of chronic ethanol administration on production of and response to erythropoietin in the mouse. Alcohol. Clin. Exp. Res., 1984; 8(3): 323- 325.
3. MEADOWS GG, WALLENDAL M, KOSUGI A, WUNDERLICH J, SINGER DS. Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol. Clin. Exp. Res., 1992; 16(3): 474-479.
4. KANWAR KC, TIKOO A. Hematological lesions in rat following heavy alcohol ingestion. J Environ. Pathol. Toxicol. Oncol., 1992; 11(4): 241-245.
5. LINDENBAUM J, ROMAN MJ. Nutritional anemia in alcoholism. Am. J. Clin. Nutr., 1980; 33(12): 2727-2735.
6. DOYLE K, HOJNACKI J, CLUETTE BROWN J, RENCRICCA N. Alterations in complete blood counts due to low to moderately high levels of dietary ethanol. Vet. Hum. Toxicol., 1988; 30(5): 423-425.
7. JERRELLS TR, MARIETTA CA, BONE G, WEIGHT FF, ECKARDT MJ. Ethanol-associated immunosuppression. Psychopharmacol., 1988; 44: 173-185. Adv. Biochem.
8. JERRELLS TR, MARIETTA CA, ECKARDT MJ, MAJCHROWICZ E, WEIGHT FF. Effects of ethanol immunocompetency in rats. J. Leukoc. Biol., 1986; 39(5): 499-510. on parameters of

9. KIM JH, PARK JS. Potentiation of the immunotoxicity of ethanol by acetaminophen in mice. Int. Immunopharmacol., 2002; 2(1): 15-24. 10. BITSCH I, MAZHARI KUNSEMULLER E, AIROLDI R, BADELT A, RONZHEIMER ERTL K. Acute effects of ethanol on hematologic parameters and acid-base metabolism of rats. Nutr. Metab., 1977; 21(1): 152- 154. S, KLAPP
10. CAREN LD, LEVEQUE JA, MANDEL AD. Effect of ethanol on the immune system in mice. Toxicol. Lett., 1983; 19(1-2): 147-153.
11. ROSELLE GA, MENDELHALL CL. Ethanol- induced alterations in lymphocyte function in the guinea pig. Alcohol. Clinical and Exper. Research., 1984; 8(1), 62-67.
12. XIAO W. Study on the joint effects of acrylonitrile and alcohol in rats. Wei. Sheng. Yan. Jiu., 1998; 27(5): 295-260.
13. FARBISZEWSKI R, MAKAREWICZ M, CHWIECKO M, KOWALCZYK T. Ethanol ingestion decreases superoxide dismutase activity and diminishes -SH compounds in the liver and red blood cells in rats. Rocz. Akad. Med. Bialymst., 1995; 40(2): 243-249.
14. KOJIMA S, KAWANO Y, ABE H, SANAI T, YOSHIDA K, IMANISHI M, ASHIDA T, KIMURA G, YOSHIMI H, MATSUOKA H. Acute effects of alcohol ingestion on blood pressure and erythrocyte sodium concentration. J. Hypertens., 1993; 11(2): 185-190.
15. HARRIS RA, CALDWELL KK. Alcohol and the calcium-dependent potassium transport of human erythrocytes. Alcohol., 1985; 2(1): 149-152.
16. GREEN RJ, BARON DN. The acute in vitro effect of ethanol, its metabolites and other toxic alcohols on ion flux in isolated human leucocytes and erythrocytes. Biochem. Pharmacol., 1986; 35(20): 3457-3464.
17. COCA A, AGUILERA MT, DE LA SIERRA A, SANCHEZ M, PICADO MJ, LLUCH MM, URBANO MARQUEZ A. Chronic alcohol intake induces reversible disturbances on cellular Na+ metabolism in humans: its relationship with changes in blood pressure. Alcohol. Clin. Exp. Res., 1992; 16(4): 714-720.
18. COCA A, GARAY R. Disturbances in Na+ transport systems induced by ethanol in human red blood cells. Alcohol. Clin. Exp. Res., 1988; 12(4): 534-538.
19. DRABKIN DL, AUSTIN JH. Spectrophotometric studies. A technique for the analysis of undiluted blood and concentrated hemoglobin solution. J Bio. Chem., 1935; 112: 105-115.
20. YAMAN K. Fizyoloji. Uludağ Üniversitesi Basımevi, Bursa 1999.
21. GONZALEZ P, TUNON MJ, DIAZ M, VALLEJO M. Blood, plasma and erythrocyte sodium concentration of six Spanish cattle breeds. Anales. de la Facultad. de Veterinari de Leon., 1984; 30: 137-145.
22. TUNON MJ, GONZALEZ P, VALLEJO M. Erythrocyte potassium polymorphism in 14 Spanish goat breeds. Anim. Genet., 1987; 18 (4): 371-375.
23. MARKS V. Clinical pathology of alcohol. J Clin. Pathol., 1983; 36: 365-378.
24. LARKIN EC, WATSON WILLIAMS EJ. Alcohol and the blood. Med. Clin. North. Amer., 1984; 68: 105-120. 26. EICHER ER. Hematologic disorders of alcoholism. Amer. J. Med., 1973; 54: 621-630.
25. EICHER ER. Macrocytic anamia. In Spivak JL, ed: Fundamentals of Clinical Hematology, Harper and Row, Philadelphia, 1984; 27-33.
26. DOYLE K, HOJNACKI J, CLUETTE BROWN J. Ethanol-induced membrane phospholipid composition. Am. J. Med. Sci., 1990; 299(2): 98-102. in erythrocyte
27. chronic ethanol intake. Alcohol., 1998; 16(4): 311- 316.