Comparison of the Effects of Prednisolon, Danazol and Testosteron Propionat Therapy in Dogs with Immune Mediated Hemolytic Anemia and Thrombocytopenia

Öz

Anahtar Kelimeler

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Comparison of the Effects of Prednisolon, Danazol and Testosteron Propionat Therapy in Dogs with Immune Mediated Hemolytic Anemia and Thrombocytopenia

Öz

Bu çalışma Prednisolon, Danazol ve Testosteron propionate’ın İmmun ilişkili anemi (İHA) ve immun ilişkili trombositopenili (İT) 45 köpeğin tedavisindeki etkinliğinin belirlenmesi ve karşılatırılması amacıyla yapıldı. Bütün köpekler 2003–2007 yılları arasında Uludağ Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniğiinde İHA ve İT taısı konan köpekler arasından seçildi. Bütün köpeklere ait klinik, hematolojik ve biyokimyasal muayeneler 3 hafta boyunca yapıldı. Çalışmada kullanılan köpekler her biri 15 köpekten oluşan 3 gruba ayrıldı; 1. Gruba immunsupresif dozajda prednisolone uygulandı. 2. Gruba Danazol ve 3. Gruba testoterone propionate uygulandı. Köpeklerde ilk muayene sonuçları arasında solgun mukoz membranlar, ikterus, hemoglobinüri, peteşi, ekimoz, melena ve epistaksis saptandı. Hemoglobin ve hematkrit düzeyleri tedavi sonunda 3. grup hayvanlara göre 1. ve 2. gruptaki hayvanlarda istatistiki olarak daha yüksek olarak saptandı (P=0.05) Trombosit sayısı tedavinin sonunda 1. ve 2. Gruptaki hayvanlarda normal sınırlar içindeydi. Sonuç olarak, prednisolone ve danazol uygulamaları tedavide etkili olurken, testosterone propionate tedavisde etkili olmadığı belirlenmiştir

Anahtar Kelimeler

• Anemi, platelet, eritrosit, kortikosteroid, androjen

Kaynakça

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