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Bakterilerde Kinolon Direncinin Genetiği

Yıl 2010, Cilt: 29 Sayı: 1, 55 - 60, 01.06.2010

Murat Cengiz

Öz

Anahtar Kelimeler

-

Kaynakça

  • Alekshun, M.N., Levy, S.B., 1999. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol., 7(10), 410-413.
  • Alekshun, M.N., Levy, S.B., 2007. Molecular mechanisms of antibacterial multidrug resistance. Cell, 128, 1037-1050.
  • Baguero, F., Martinez, J.L., Canton, R., 2008. Antibiotics and antibiotic resistance in water environments. Curr. Opin. Biotech., 19, 260-265.
  • Castiglioni, S., Romati, F., Miller, K., Burns, B.P., Zuccato, E., Calamari, D., Neilan, B.A., 2008. Novel homologs of the multiple resistance regulator marA in antibiotic-contaminated environments Water Res., 42, 4271-4280.
  • Gambino, L., Gracheck, S.J., Miller, P.F., 1993. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. J. Bacteriol., 175(10), 2888- 2894. 6. Hooper, D., 1999. Mechanisms of fluoroquinolone resistance. Drug Resist. Update, 2, 38-55.
  • Hopkins, K.L., Davies, R.H., Threfall, E.J., 2005. Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. Int. J. Antimicrob. Ag., 25, 358- 373.
  • Hunter, P.A., Dawson, S., Frech, G.L., Goossens, H., Hawkey, P.M., Kuijper E.J., Nathwani, D., Taylor, D.J., Teale, C.J., Warren, R.E., Wilcox, M.H., Woodford, N., Wulf, M.W., Piddock, L.J.V., 2010. Antimicrobial-resistant pathogens in animals and man: prescribing practices and policies. J. Antimicrob. Chemother., 65 (Suppl. 1), i3-i17.
  • Intorre, L., Vanni, M., Di Bello, D., Pretti, C., Meucci, V., Tognetti, R., Soldani, G., Cardini, G., susceptibility and mechanism of resistance to fluoroquinolones in Staphylococcus intermedius and Staphylococcus schleiferi. J. Vet. Pharmacol. Therap., 30, 464-469. 2007. Antmicrobial
  • Kato, J.I., Suzuki, H., Ikeda, H., 1992. Purification and characterization of DNA topoisomerase IV in Escherichia coli. J. Biol. Chem., 267, 25676-25684.
  • Khan, A.A., Nawaz, M.S., West, C.S., Khan, S.A., Lint, J., 2005. Isolation and molecular characterization of fluoroquinolone resistant Escherichia coli from poultry litter. Poultry Sci., 84, 61-66.
  • Lee, Y.J., Cho, J.K., Kim, K.S., Tak, R.B., Kim, A.R., Kim, J.W., Im, S.K., Kim, B.H., 2005. Fluoroquinolone resistance and gyrA and parC mutations of Escherichia coli isolated from chicken. J. Microbiol., 43(5), 391-397.
  • Litran-Maria, T., Allison, D.G., Gilbert, P., 2000. Expression of the multiple antibiotic resistance operon (mar) during growth of Escherichia coli as a biofilm. J. Appl. Microbiol., 88, 243-247.
  • Martinez-Martinez, L., Pascual, A., Jacoby, G.A., 1998. Quinolone resistance from a transferable plasmid. Lancet, 351, 797-799.
  • Martinez, M., McDermott, P., Walker, R., 2006. Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. Brit. Vet. J., 172, 10-28.
  • Martinez, J.L., 2009. Environmental pollution by antibiotics determinants. Environ. Pollut., 157, 2893-2902.
  • Miles, T.D., McLaughlin, W., Brown, P.D., 2006. Antimicrobial resistance of Escherichia coli isolates from broiler chickens and humans. BMC Vet. Res., 2, 7-9.
  • Nikaido, H., 1998. Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol., 1, 516-523.
  • Orden, J.A., Ruiz-Santa-Quiteria, J.A., Cid, D., Diez, R., Martinez, S., de la Fuente, R., 2001. Quinolone resistance in potentially pathogenic and non-pathogenic Escherichia coli strains isolated from healthy ruminants. J. Antimicrob. Chemoth., 48, 421-424.
  • Park, Y.H., Yoo, J.H., Huh, D.H., Cho, Y.K., Choi, J.H., Shin, W.S., 1998. Molecular analysis of fluoroquinolone resistance in Escherichia coli on the aspect of gyrase and multiple antibiotic resistance (mar) genes. Yonsei Med. J., 39(6), 534-540.
  • Randall, L.P., Woodward, M.J., 2002. The multiple antibiotic resistance (mar) locus and its significance. Res. Vet. Sci., 72, 87-93.
  • Robicsek, A., Jacoby, G.A., Hooper, D., 2006. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis., 6, 629- 640.
  • Servais, P., Passerat, J., 2009. Antimicrobial resistance of fecal bacteria in waters of the Seine river watershed (France). Sci. Total Environ., 408, 365-372.
  • Shaheen, B.W., Wang, C., Johnson, C.M., Kaltenboeck, B., Boothe, D.M., 2009. Detection of fluoroquinolone resistance level in clinical ca- nine and feline Escherichia coli pathogens using rapid real-time PCR assay. Vet. Microbiol., 139, 379-385. 25. Stavoe, A.K.H., 2006. quinolone and fluoroquinolone resistance. MMG 445 Basic Biotech. eJ., 2, 154-159.
  • Tran, J.H., Jacoby, G.A., 2002. Mechanism of plasmid-mediated quinolone resistance. PNAS, 99(8), 5638-5642.
  • Venglovsky, J., Sasakova, N., Placha, I., 2009. Pathogens and antibiotic residues in animal manures and hygienic and ecological risks related to subsequent land application. Bioresource Technol., 100, 5386-5391.
  • Werner, G., Fleige, C., Ewert, B., Lavarde- Gornez, J.A., Klare, I., Witte, W., 2010. High- level ciprofloxacin resistance among hospital- adapted Enterococcus faecium (CC17). Int. J. Antimicrob. Ag., 35, 119-125.
  • Yang, J., Luo, Y., Li, J., Ma, Y., Hu, C., Jin S., Ye, L., Cui, S., 2010. Characterization of clinical Escherichia coli isolates from China containing transferable quinolone resistance determinants. J. Antimicrob. Chemother., 478, 1-7.
  • Yu, D., Yi, X., Ma, Y., Yin, B., Zhuo, H., Li, J., Huang, Y., 2009. Effects of administration mode of antibiotics on antibiotic resistance of Enterococcus feacalis in aquatic ecosystems. Chemosphere, 76, 915-920.

Bakterilerde Kinolon Direncinin Genetiği

Yıl 2010, Cilt: 29 Sayı: 1, 55 - 60, 01.06.2010

Murat Cengiz

Öz

Bakteriyel direnç, tür çeşitliliği ve biyolojik etkileşim dolayısıyla genetik değişimlerin kolayca oluşabildiği genetik reaktörlerde ortaya çıkar. Son yıllarda kinolon direnci ve kalıntıları, bu gruptaki antibiyotiklerin yaygın kullanımı nedeniyle yoğun ilgi toplayan bir alandır. Kinolon direncinin oluşmasından sorumlu olan birkaç mekanizma vardır. Bu genetik mekanizmalar: kinolon direnci belirleyici bölgede meydana gelen gyrA ve ParC mutasyonları, qnr ve analogları tarafından plazmid aracılı direncin kodlanması ve bakteri membran proteinlerinin sayısını azaltarak düşük etkili bir direncin oluşmasına neden olan mar mutasyonlarıdır. Direncin aktarılabilir niteliğinin de olması dolayısıyla insan ve hayvan sağlığı genetik reaktörlerde kinolon direnç etmenlerinin çoğalmasından olumsuz etkilenir. Ayrıca, henüz somut bir kanıt sunulamamış olsa da çevrede bulunan kinolon kalıntıları direncin gelişmesine neden olabilir. Direncin insan ve hayvan sağlığı üzerindeki istenmeyen etkilerini ortadan kaldırmak için koruyucu önlemler alınmalıdır. Bunun için kinolon direncinin karakterize edilmesi önemlidir ve mevcut tedavi protokolleri in vitro farmakodinamik yöntemler yardımıyla geliştirilebilir

Anahtar Kelimeler

Kinolon direnç genetik

Kaynakça

  • Alekshun, M.N., Levy, S.B., 1999. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol., 7(10), 410-413.
  • Alekshun, M.N., Levy, S.B., 2007. Molecular mechanisms of antibacterial multidrug resistance. Cell, 128, 1037-1050.
  • Baguero, F., Martinez, J.L., Canton, R., 2008. Antibiotics and antibiotic resistance in water environments. Curr. Opin. Biotech., 19, 260-265.
  • Castiglioni, S., Romati, F., Miller, K., Burns, B.P., Zuccato, E., Calamari, D., Neilan, B.A., 2008. Novel homologs of the multiple resistance regulator marA in antibiotic-contaminated environments Water Res., 42, 4271-4280.
  • Gambino, L., Gracheck, S.J., Miller, P.F., 1993. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. J. Bacteriol., 175(10), 2888- 2894. 6. Hooper, D., 1999. Mechanisms of fluoroquinolone resistance. Drug Resist. Update, 2, 38-55.
  • Hopkins, K.L., Davies, R.H., Threfall, E.J., 2005. Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. Int. J. Antimicrob. Ag., 25, 358- 373.
  • Hunter, P.A., Dawson, S., Frech, G.L., Goossens, H., Hawkey, P.M., Kuijper E.J., Nathwani, D., Taylor, D.J., Teale, C.J., Warren, R.E., Wilcox, M.H., Woodford, N., Wulf, M.W., Piddock, L.J.V., 2010. Antimicrobial-resistant pathogens in animals and man: prescribing practices and policies. J. Antimicrob. Chemother., 65 (Suppl. 1), i3-i17.
  • Intorre, L., Vanni, M., Di Bello, D., Pretti, C., Meucci, V., Tognetti, R., Soldani, G., Cardini, G., susceptibility and mechanism of resistance to fluoroquinolones in Staphylococcus intermedius and Staphylococcus schleiferi. J. Vet. Pharmacol. Therap., 30, 464-469. 2007. Antmicrobial
  • Kato, J.I., Suzuki, H., Ikeda, H., 1992. Purification and characterization of DNA topoisomerase IV in Escherichia coli. J. Biol. Chem., 267, 25676-25684.
  • Khan, A.A., Nawaz, M.S., West, C.S., Khan, S.A., Lint, J., 2005. Isolation and molecular characterization of fluoroquinolone resistant Escherichia coli from poultry litter. Poultry Sci., 84, 61-66.
  • Lee, Y.J., Cho, J.K., Kim, K.S., Tak, R.B., Kim, A.R., Kim, J.W., Im, S.K., Kim, B.H., 2005. Fluoroquinolone resistance and gyrA and parC mutations of Escherichia coli isolated from chicken. J. Microbiol., 43(5), 391-397.
  • Litran-Maria, T., Allison, D.G., Gilbert, P., 2000. Expression of the multiple antibiotic resistance operon (mar) during growth of Escherichia coli as a biofilm. J. Appl. Microbiol., 88, 243-247.
  • Martinez-Martinez, L., Pascual, A., Jacoby, G.A., 1998. Quinolone resistance from a transferable plasmid. Lancet, 351, 797-799.
  • Martinez, M., McDermott, P., Walker, R., 2006. Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. Brit. Vet. J., 172, 10-28.
  • Martinez, J.L., 2009. Environmental pollution by antibiotics determinants. Environ. Pollut., 157, 2893-2902.
  • Miles, T.D., McLaughlin, W., Brown, P.D., 2006. Antimicrobial resistance of Escherichia coli isolates from broiler chickens and humans. BMC Vet. Res., 2, 7-9.
  • Nikaido, H., 1998. Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol., 1, 516-523.
  • Orden, J.A., Ruiz-Santa-Quiteria, J.A., Cid, D., Diez, R., Martinez, S., de la Fuente, R., 2001. Quinolone resistance in potentially pathogenic and non-pathogenic Escherichia coli strains isolated from healthy ruminants. J. Antimicrob. Chemoth., 48, 421-424.
  • Park, Y.H., Yoo, J.H., Huh, D.H., Cho, Y.K., Choi, J.H., Shin, W.S., 1998. Molecular analysis of fluoroquinolone resistance in Escherichia coli on the aspect of gyrase and multiple antibiotic resistance (mar) genes. Yonsei Med. J., 39(6), 534-540.
  • Randall, L.P., Woodward, M.J., 2002. The multiple antibiotic resistance (mar) locus and its significance. Res. Vet. Sci., 72, 87-93.
  • Robicsek, A., Jacoby, G.A., Hooper, D., 2006. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect. Dis., 6, 629- 640.
  • Servais, P., Passerat, J., 2009. Antimicrobial resistance of fecal bacteria in waters of the Seine river watershed (France). Sci. Total Environ., 408, 365-372.
  • Shaheen, B.W., Wang, C., Johnson, C.M., Kaltenboeck, B., Boothe, D.M., 2009. Detection of fluoroquinolone resistance level in clinical ca- nine and feline Escherichia coli pathogens using rapid real-time PCR assay. Vet. Microbiol., 139, 379-385. 25. Stavoe, A.K.H., 2006. quinolone and fluoroquinolone resistance. MMG 445 Basic Biotech. eJ., 2, 154-159.
  • Tran, J.H., Jacoby, G.A., 2002. Mechanism of plasmid-mediated quinolone resistance. PNAS, 99(8), 5638-5642.
  • Venglovsky, J., Sasakova, N., Placha, I., 2009. Pathogens and antibiotic residues in animal manures and hygienic and ecological risks related to subsequent land application. Bioresource Technol., 100, 5386-5391.
  • Werner, G., Fleige, C., Ewert, B., Lavarde- Gornez, J.A., Klare, I., Witte, W., 2010. High- level ciprofloxacin resistance among hospital- adapted Enterococcus faecium (CC17). Int. J. Antimicrob. Ag., 35, 119-125.
  • Yang, J., Luo, Y., Li, J., Ma, Y., Hu, C., Jin S., Ye, L., Cui, S., 2010. Characterization of clinical Escherichia coli isolates from China containing transferable quinolone resistance determinants. J. Antimicrob. Chemother., 478, 1-7.
  • Yu, D., Yi, X., Ma, Y., Yin, B., Zhuo, H., Li, J., Huang, Y., 2009. Effects of administration mode of antibiotics on antibiotic resistance of Enterococcus feacalis in aquatic ecosystems. Chemosphere, 76, 915-920.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Murat Cengiz Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2010
Yayımlandığı Sayı Yıl 2010 Cilt: 29 Sayı: 1

Kaynak Göster

APA Cengiz, M. (2010). Bakterilerde Kinolon Direncinin Genetiği. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 29(1), 55-60.
AMA Cengiz M. Bakterilerde Kinolon Direncinin Genetiği. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. Haziran 2010;29(1):55-60.
Chicago Cengiz, Murat. “Bakterilerde Kinolon Direncinin Genetiği”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 29, sy. 1 (Haziran 2010): 55-60.
EndNote Cengiz M (01 Haziran 2010) Bakterilerde Kinolon Direncinin Genetiği. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 29 1 55–60.
IEEE M. Cengiz, “Bakterilerde Kinolon Direncinin Genetiği”, Uludağ Üniversitesi Veteriner Fakültesi Dergisi, c. 29, sy. 1, ss. 55–60, 2010.
ISNAD Cengiz, Murat. “Bakterilerde Kinolon Direncinin Genetiği”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 29/1 (Haziran 2010), 55-60.
JAMA Cengiz M. Bakterilerde Kinolon Direncinin Genetiği. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2010;29:55–60.
MLA Cengiz, Murat. “Bakterilerde Kinolon Direncinin Genetiği”. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, c. 29, sy. 1, 2010, ss. 55-60.
Vancouver Cengiz M. Bakterilerde Kinolon Direncinin Genetiği. Uludağ Üniversitesi Veteriner Fakültesi Dergisi. 2010;29(1):55-60.