Influence of Acute Serious Haemorrhagic Shock on Erythrocyte Glutathione and Sodium – Potassium Contents

Yıl 2005, Cilt: 24 Sayı: 1-2-3-4, 15 - 19, 01.06.2005

Murat Yalçın Nurten Galip

Öz

Anahtar Kelimeler

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Influence of Acute Serious Haemorrhagic Shock on Erythrocyte Glutathione and Sodium – Potassium Contents

Öz

Çalışmanın amacı akut ciddi kan kaybında alyuvar glutatyon ve alyuvar sodium – potasyum seviyesini belirlemektir. Çalışmada 15 adet Sprague Dawley ırkı erkek yetişkin sıçan kullanılmıştır. Kanatma işlemi 10 dakikalık bir periyotta 100 g vücut ağırlığı başına 2.1 ml kan alınarak gerçekleştirildi. Kan örnekleri kanatmadan önce ve kanatmadan 1 saat sonra olmak üzere iki kez toplandı. Kanatma, hematokrit, alyuvar sayısı ve hemoglobin miktarında yaklaşık % 20, arterial kan basıncında yaklaşık % 60 ve kalp atım sayısında yaklaşık olarak % 46 artmaya neden oldu. İlginç olarak alyuvar glutatyon seviyesi, kanama öncesi ve kanama sonrasında değişiklik göstermedi. Ayrıca, kanama plazma ve alyuvar sodyum seviyelerini arttırırken plazma ve alyuvar potasyum seviyelerini düşürdü. Sonuçta, hemorajik şoktan dolayı reaktif oksijen türlerinin üretimi artabilir ve bu da azalan alyuvarlar glutatyon üretimini artırarak antioksidan savunmayı düzenlemeye ve oksidatif strese cevap vermeye çalışıyor olabilir. Ayrıca, ciddi kan kaybından kaynaklanan alyuvarlarda düşük potasyum seviyesi ile birlikte yüksek sodyum konsantrasyonu hücresel fonksiyonlarda defekte neden olabilir

Anahtar Kelimeler

Kan Kaybı, Şok, Alyuvar, Glutatyon, Sodyum ve Potasyum

Kaynakça

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