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Extracellular Matrix Structure and Tasks

Yıl 2018, Cilt: 23 Sayı: 1, 295 - 310, 24.04.2018
https://doi.org/10.17482/uumfd.327376

Öz

The extracellular matrix (ECM) is a complex
structure located between and supporting cells within mammalian tissues. The
ECM is secreted by cells in contact or contact. Extracellular matrix (ECM) is
traditionally classified as glycosphingolipids and fibrous proteins. In
glycosphingolipids, they are divided into two groups: non-sulfated proteins
(hyaluronic acid) and sulfated proteins (chondroitin sulfate, keratin sulphate
I and II, heparin, heparan sulfate and dermatan sulphate). Fibrous proteins are
classified as structural proteins (collagen, elastin) and adhesion proteins
(fibronectin, laminin, tenascin, vitronectin, integrin).This work deals with the
structure of the extracellular matrix molecule affecting cell growth and
differentiation, affecting cell growth and differentiation, water and minerals
affecting the growth factor, and the proteins involved in this structure.

Kaynakça

  • Akgün, I., Öğüt, T., (2002) Oral Glukozamin ve Kondroitin Sülfatın Osteoartrit Tedavideki Yeri. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 1(2), 66-70.
  • Alovskaya, A., Alekseeva, T., Phillips, J.B., King, V., Brown, R., (2007) Fibronectin, collagen, fibrin-components of extracellular matrix for nerve regeneration. Topics in Tissue Engineering, 3, 1-26.
  • Ata, R., Antonescu, C.N., (2017) Integrins and Cell Metabolism: an Intimate Relationship Impacting Cancer. International Journal of Molecular Sciences, 18(189), 1-31. doi:10.3390/ijms18010189
  • Aviezer, D., Safran, M., Yayon, A., (1999) Heparin Differentially Regulates the Interaction of Fibroblast Growth Factor-4 with FGF Receptors 1 And 2. Biochemical and Biophysical Research Communications, 263(3), 621-626. doi: 10.1006/bbrc.1999.1434
  • Barczyk, M., Carracedo, S., Gullberg, D., 2010. Integrins. Cell Tissue Research, 339, 269-280. doi: 10.1007/s00441-009-0834-6.
  • Bayram, C., 2012. Hücre ve Doku Mühendisliği Araştırma Grubu. Nanoteknoloji ve Nanotıp Bilim Dergisi (N@nobülten), 18-27.
  • Bosman, F., ve Stamenkovic, I., (2003) Functional Structure and Composition of the Extracellular Matrix. Journal of Pathology, 200(4), 423-428. doi: 10.1002/path.1437
  • Campbell I.D., Humphries, M.J., (2011) Integrin Structure, Activation, and Interactions. Cold Spring Harbor Perspectives in Biology, 3, 1-14. doi: 10.1101/cshperspect.a004994
  • Cantor, J.O., Shteyngart, B, Cerreta, J.M., Lıu, M, Armand, G., Turıno, G.M., (2000) The Effect of Hyaluronan on Elastic Fiber Injury in Vitro and Elastaseinduced Airspace Enlargement in Vivo. Experimental Biology and Medicine, 225(1), 65– 71.
  • Chiquet-Ehrismann, R., (1990) What distinguishes tenascin from fibronectin? FASEB Journal, 4(9), 2598-2604.
  • Çavdar, Z., (2008) Kolon ve Rektum Kanserlerinde Endostatin’in Matriks Metalloproteinaz-2 Üzerine Gösterdiği Etkinin Araştırılması. Dokuz Eylül Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, Doktora Tezi, 144s., İzmir.
  • De Medeiros Matsushita M., Da Silva, L.F., Dos Santos, M.A., Fernezlian, S., Schrumpf, J.A., Roughley, P., Hiemstra, P.S., Saldiva, P.H., Mauad, T., Dolhnikoff, M., (2005) Airway Proteoglycans are Differentially Altered in Fatal Asthma. The Journal of Pathology, 207(1), 102-110. doi: 10.1002/path.1818
  • Debelle, L., Tamburro, A.M., (1999) Elastin: Molecular Description And Function. The International Journal of Biochemistry & Cell Biology, 31(2), 261-272. doi.org/10.1016/S1357-2725(98)00098-3
  • Frantz, C., Stewart, K.M., Weaver, V.M., (2010) The Extracellular Matrix at a Glance. Journal of Cell Science, 123(24), 4195-4200. doi: 10.1242/jcs.023820
  • Funderburgh, J.L., (2000) Keratan sulfate: structure, biosynthesis and function. Glycobiology, 10, 951-958. doi.org/10.1093/glycob/10.10.951
  • Funderburgh, J.L., (2002) Keratan Sulfate Biosynthesis. IUBMB Life, 54,187–194. doi: 10.1080/15216540214932
  • Gerdin, B., Hällgren, R., (1997) Dynamic Role of Hyaluronan (HYA) in Connective Tissue Activation and Inflammation. Journal of Internal Medicine, 242(1), 49–55. doi: 10.1046/j.1365-2796.1997.00173.x
  • Gill, S., Wight, T.N., Frevert, C.W., (2010) Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection. Anat Rec (Hoboken), 293(6), 968-981. doi: 10.1002/ar.21094
  • Green, W.F., Konnaris, K., Woolcock, A.J., 1993. Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides Pteronyssinus Allergen. American Journal of Respiratory Cell and Molecular Biology, 8(5), 518-521. doi: 10.1165/ajrcmb/8.5.518
  • Gullberg, D., (2003) I domains in integrins. vol 1. Landes Bioscience, Georgetown, Texas. pp 1–185. doi:10.1007/978-94-017-9153-3
  • Gümüşderelioğlu, M., Maviş, B., Karakeçili, A., Kahraman, A.S., Çakmak, S., Tığlı, S., Demirtaş, T., Aday, S., 2007. Doku Mühendisliğinde Nanoteknoloji. Bilim ve Teknik Dergisi, Yeni Ufuklara Eki, Ekim Sayısı.
  • Gürbüz, Y., Aydın, Ö., Almaç, A., (2006) Tenascin Expression Patterns Of Salivary Gland Tumors: An Immunhistochemical And Comparative Study. KBB-Forum Dergisi, 5(1), 35-40.
  • Handel, T.M., Johnson, Z., Crown, S.E., Lau, E.K., Proudfoot, A.E., (2005) Regulation of Protein Function by Glycosaminoglycans-as Exemplified by Chemokines. Annual Review of Biochemistry, 74, 385-410. doi: 10.1146/annurev.biochem.72.121801.161747
  • Hynes, R.O., (2002) Integrins: Bidirectional, Allosteric Signaling Machines. Cell, 110, 673-687. doi.org/10.1016/S0092-8674(02)00971-6
  • Järveläinen, H., Sainio, A., Koulu, M., Wight, T.N., Penttienen, R., (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews, 61(2), 198-223. doi: 10.1124/pr.109.001289
  • Johansson, S., Svineng, G., Wennerberg, K., Armulik, A., Lohikangas, L., (1997) Fibronectin-Integrin Interactions. Frontiers in Bioscience 2, 126-146.
  • Kansu, E., 1996. Hücre Adhezyon Sistemi. Antibiyotik ve Kemoterapi Derneği Dergisi, 10(3), 314-317.
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EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ

Yıl 2018, Cilt: 23 Sayı: 1, 295 - 310, 24.04.2018
https://doi.org/10.17482/uumfd.327376

Öz

Ekstrasellüler
matriks (ECM), memeli dokuları içindeki hücrelerin arasında bulunan ve onları
destekleyen bir kompleks yapıdır. ECM içinde bulunduğu veya temas halindeki
hücreler tarafından salgılanmaktadır. Ekstrasellüler matriks (ECM), geleneksel
olarak glikoaminglikanlar ve fibröz proteinler olarak sınıflandırılırlar.
Glikoaminglikanlarda kendi içlerinde sülfatlanmamış proteinler (Hyalüronik
asit) ve sülfatlanmış proteinler (kondroitin sülfat, keratan sülfat I ve II,
heparin, heparan sülfat ve dermatan sülfat) olmak üzere ikiye ayrılır. Fibröz
proteinler ise yapısal proteinler (kollajen, elastin) ve yapıştırıcı (adhezyon)
proteinler (Fibronektin, laminin, tenaskin, vitronektin, integrin) olarak
sınıflandırılır. 
Yapılan
bu çalışma ile hücrelerin yapısı ve hareketini etkileyen, hücre gelişme ve
farklılaşmasını etkileyen, su ve mineral tutan, büyüme faktörünü etkileyen ekstrasellüler
matris molekülünün yapısı ve bu yapıda bulunan proteinlerin görevlerinden
bahsedilmiştir.

Kaynakça

  • Akgün, I., Öğüt, T., (2002) Oral Glukozamin ve Kondroitin Sülfatın Osteoartrit Tedavideki Yeri. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 1(2), 66-70.
  • Alovskaya, A., Alekseeva, T., Phillips, J.B., King, V., Brown, R., (2007) Fibronectin, collagen, fibrin-components of extracellular matrix for nerve regeneration. Topics in Tissue Engineering, 3, 1-26.
  • Ata, R., Antonescu, C.N., (2017) Integrins and Cell Metabolism: an Intimate Relationship Impacting Cancer. International Journal of Molecular Sciences, 18(189), 1-31. doi:10.3390/ijms18010189
  • Aviezer, D., Safran, M., Yayon, A., (1999) Heparin Differentially Regulates the Interaction of Fibroblast Growth Factor-4 with FGF Receptors 1 And 2. Biochemical and Biophysical Research Communications, 263(3), 621-626. doi: 10.1006/bbrc.1999.1434
  • Barczyk, M., Carracedo, S., Gullberg, D., 2010. Integrins. Cell Tissue Research, 339, 269-280. doi: 10.1007/s00441-009-0834-6.
  • Bayram, C., 2012. Hücre ve Doku Mühendisliği Araştırma Grubu. Nanoteknoloji ve Nanotıp Bilim Dergisi (N@nobülten), 18-27.
  • Bosman, F., ve Stamenkovic, I., (2003) Functional Structure and Composition of the Extracellular Matrix. Journal of Pathology, 200(4), 423-428. doi: 10.1002/path.1437
  • Campbell I.D., Humphries, M.J., (2011) Integrin Structure, Activation, and Interactions. Cold Spring Harbor Perspectives in Biology, 3, 1-14. doi: 10.1101/cshperspect.a004994
  • Cantor, J.O., Shteyngart, B, Cerreta, J.M., Lıu, M, Armand, G., Turıno, G.M., (2000) The Effect of Hyaluronan on Elastic Fiber Injury in Vitro and Elastaseinduced Airspace Enlargement in Vivo. Experimental Biology and Medicine, 225(1), 65– 71.
  • Chiquet-Ehrismann, R., (1990) What distinguishes tenascin from fibronectin? FASEB Journal, 4(9), 2598-2604.
  • Çavdar, Z., (2008) Kolon ve Rektum Kanserlerinde Endostatin’in Matriks Metalloproteinaz-2 Üzerine Gösterdiği Etkinin Araştırılması. Dokuz Eylül Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, Doktora Tezi, 144s., İzmir.
  • De Medeiros Matsushita M., Da Silva, L.F., Dos Santos, M.A., Fernezlian, S., Schrumpf, J.A., Roughley, P., Hiemstra, P.S., Saldiva, P.H., Mauad, T., Dolhnikoff, M., (2005) Airway Proteoglycans are Differentially Altered in Fatal Asthma. The Journal of Pathology, 207(1), 102-110. doi: 10.1002/path.1818
  • Debelle, L., Tamburro, A.M., (1999) Elastin: Molecular Description And Function. The International Journal of Biochemistry & Cell Biology, 31(2), 261-272. doi.org/10.1016/S1357-2725(98)00098-3
  • Frantz, C., Stewart, K.M., Weaver, V.M., (2010) The Extracellular Matrix at a Glance. Journal of Cell Science, 123(24), 4195-4200. doi: 10.1242/jcs.023820
  • Funderburgh, J.L., (2000) Keratan sulfate: structure, biosynthesis and function. Glycobiology, 10, 951-958. doi.org/10.1093/glycob/10.10.951
  • Funderburgh, J.L., (2002) Keratan Sulfate Biosynthesis. IUBMB Life, 54,187–194. doi: 10.1080/15216540214932
  • Gerdin, B., Hällgren, R., (1997) Dynamic Role of Hyaluronan (HYA) in Connective Tissue Activation and Inflammation. Journal of Internal Medicine, 242(1), 49–55. doi: 10.1046/j.1365-2796.1997.00173.x
  • Gill, S., Wight, T.N., Frevert, C.W., (2010) Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection. Anat Rec (Hoboken), 293(6), 968-981. doi: 10.1002/ar.21094
  • Green, W.F., Konnaris, K., Woolcock, A.J., 1993. Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides Pteronyssinus Allergen. American Journal of Respiratory Cell and Molecular Biology, 8(5), 518-521. doi: 10.1165/ajrcmb/8.5.518
  • Gullberg, D., (2003) I domains in integrins. vol 1. Landes Bioscience, Georgetown, Texas. pp 1–185. doi:10.1007/978-94-017-9153-3
  • Gümüşderelioğlu, M., Maviş, B., Karakeçili, A., Kahraman, A.S., Çakmak, S., Tığlı, S., Demirtaş, T., Aday, S., 2007. Doku Mühendisliğinde Nanoteknoloji. Bilim ve Teknik Dergisi, Yeni Ufuklara Eki, Ekim Sayısı.
  • Gürbüz, Y., Aydın, Ö., Almaç, A., (2006) Tenascin Expression Patterns Of Salivary Gland Tumors: An Immunhistochemical And Comparative Study. KBB-Forum Dergisi, 5(1), 35-40.
  • Handel, T.M., Johnson, Z., Crown, S.E., Lau, E.K., Proudfoot, A.E., (2005) Regulation of Protein Function by Glycosaminoglycans-as Exemplified by Chemokines. Annual Review of Biochemistry, 74, 385-410. doi: 10.1146/annurev.biochem.72.121801.161747
  • Hynes, R.O., (2002) Integrins: Bidirectional, Allosteric Signaling Machines. Cell, 110, 673-687. doi.org/10.1016/S0092-8674(02)00971-6
  • Järveläinen, H., Sainio, A., Koulu, M., Wight, T.N., Penttienen, R., (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews, 61(2), 198-223. doi: 10.1124/pr.109.001289
  • Johansson, S., Svineng, G., Wennerberg, K., Armulik, A., Lohikangas, L., (1997) Fibronectin-Integrin Interactions. Frontiers in Bioscience 2, 126-146.
  • Kansu, E., 1996. Hücre Adhezyon Sistemi. Antibiyotik ve Kemoterapi Derneği Dergisi, 10(3), 314-317.
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  • Lozzo, R.V., Murdoch, A.D., (1996) Proteoglycans of the Extracellular Environment: Clues From the Gene and Protein Side Offer Novel Perspectives in Molecular Diversity and Function. The FASEB Journal, 10(5), 598-614.
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  • Page, C.P., (1997) Proteoglycans: the "Teflon" of the Airways?. Thorax, 52(10), 924-925. doi.org/10.1136/thx.52.10.924
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  • Pelosi, P., Rocco, P.R.M., Negrini, D., Passi, A., (2007) The Extracellular Matrix of the Lung And its Role in Edema Formation. Annals of the Brazilian Academy of Sciences, 79(2), 285-297. doi.org/10.1590/S0001-37652007000200010
  • Pelosi, P., Severgnini, P., Rocco, P.R.M., (2007) The Extracellular Matrix of the Lung. Intersive Care Medicine, Spinger Press, 1040 s., Germany. doi: 10.1007/978-3-540-49433-1_29
  • Perdom, G., (2008) Laminin and the Cross Is There a Connection. Answers in Depth, 3, 83-84. Erişim Adresi: https://assets.answersingenesis.org/doc/articles/aid/v3/laminin-cross.pdf (Erişim Tarihi: 05.07.2017)
  • Pereira, I.O., (2011) Design and Construction of a Decellularization Cell. Faculdade de Engenharia, Mestrado Integrado em Bioengenharia, 87 p., Porto.
  • Rozario, T., DeSimone, D.W., (2010) The Extracellular Matrix in Development and Morphogenesis: A Dynamic View. Developmental Biology, 341(1), 126-140. doi: 10.1016/j.ydbio.2009.10.026
  • Ruoss, S.J., Gold, W.M., Caughey, G.H., (1991) Mast Cell Exocytosis: Evidence That Granule Proteoglycan Processing is not Coupled to Degranulation. Biochemical and Biophysical Research Communications, 179(1), 140-146. doi.org/10.1016/0006-291X(91)91346-E
  • Sasaki, M., Kleinman, H.K., Hubert, H., Deutzmann, R., Yamada, Y., (1988) Laminin, a Multidomain Protein. The Journal Of Biological Chemistry, 263(32), 16536-16544.
  • Scott, J.E., (1992) Supramolecular Organization of Extracellular Matrix Glycosaminoglycans, in Vitro and in The Tissues. The FASEB Journal, 6(9), 2639-2645.
  • Seyfeli, S., Üstünel, İ., Değer, N., Demir, R., (2001) Ekstrasellüler Matriks ve Bazı Kardiovasküler Hastalıklarla İlişkisi. Türkiye Klinikleri Kardiyoloji Dergisi, 14(6), 359-369.
  • Šimánek, V., Křen, V., Ulrichová, J., Gallo, J., (2005) The Efficacy of Glucosamine and Chondroitin Sulfate in the Treatment of Osteoarthritis: Are These Saccharides Drugs or Nutraceuticals. Biomedical Papers, 149(1), 51-56.
  • Sköld, C.M., Blaschke, E., Eklund, A., (1996) Transient Increases in Albumin and Hyaluronan in Bronchoalveolar Lavage Fluid After Quitting Smoking: Possible Signs of Reparative Mechanisms. Respiratory Medicine, 90(9), 523-529.
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  • Uslu, B., Arbak, S., 2010. Doku Mühendisliğinde Kitosanın Kullanım Alanları. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 1(3), 128-135.
  • Wilusz, R.E., Sanchez-Adams, J., Guilak, F., (2014) The Structure and Function of the Pericellular Matrix of Articular Cartilage. Journal of the International Society for Matrix Biology, 39, 25-32. doi: 10.1016/j.matbio.2014.08.009
  • Wong, E.V., (2009) Cells: Molecules and Mechnisms. Axolotl Academic Publishing Company, 271 p., Louisville, Kentucky/USA.
  • Xu, J., Mosher, D., (2011) Fibronectin and Other Adhesive Glycoproteins. The Extracellular Matrix: an Overview, Biology of Extracellular Matrix, Mecham, R. (Ed), 426, Springer-Verlag Berlin Heidelberg.
  • Yiğit, A., Yiğit, B., Koşar, Aslan, P., Savaş, H.B., Korkmaz, M., 2016. Doku Mühendisliğinde Deselülerizasyon Metotları ile Ekstraselüler Matriks (ECM) Eldesi ve Tıbbi Tedavide Uygulama Alanları. Kimya ve Sanayi Dergisi, 2(6), 29-43.
  • Yurchenco P.D., Schittny, J.C., (1990) Molecular Architecture of Basement Membranes. The FASEB Journal, 4(6), 1577-1590.
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  • Zhu, J.K., Damsz, B., Kononowicz, A.K., Bressan, R.A., Hasegawa, P.M., (1994) A Higher Plant Extracellular Vitronectin-like Adhesion Protein Is Related to the Translational Elongation Factor-Iα. American Society of Plant Physiologists, 6, 393-404. doi: 10.1105/tpc.6.3.393
Toplam 73 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Derleme Makaleler
Yazarlar

İbrahim Üçgül

Sultan Aras

Ufuk Elibüyük

Yayımlanma Tarihi 24 Nisan 2018
Gönderilme Tarihi 8 Temmuz 2017
Kabul Tarihi 22 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 23 Sayı: 1

Kaynak Göster

APA Üçgül, İ., Aras, S., & Elibüyük, U. (2018). EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, 23(1), 295-310. https://doi.org/10.17482/uumfd.327376
AMA Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. Nisan 2018;23(1):295-310. doi:10.17482/uumfd.327376
Chicago Üçgül, İbrahim, Sultan Aras, ve Ufuk Elibüyük. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23, sy. 1 (Nisan 2018): 295-310. https://doi.org/10.17482/uumfd.327376.
EndNote Üçgül İ, Aras S, Elibüyük U (01 Nisan 2018) EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23 1 295–310.
IEEE İ. Üçgül, S. Aras, ve U. Elibüyük, “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”, UUJFE, c. 23, sy. 1, ss. 295–310, 2018, doi: 10.17482/uumfd.327376.
ISNAD Üçgül, İbrahim vd. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi 23/1 (Nisan 2018), 295-310. https://doi.org/10.17482/uumfd.327376.
JAMA Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. 2018;23:295–310.
MLA Üçgül, İbrahim vd. “EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ”. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, c. 23, sy. 1, 2018, ss. 295-10, doi:10.17482/uumfd.327376.
Vancouver Üçgül İ, Aras S, Elibüyük U. EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. UUJFE. 2018;23(1):295-310.

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